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  • Corsini, ChristianUppsala University,Uppsala universitet,Institutionen för kirurgiska vetenskaper,IRCCS San Raffaele Hosp, Urol Res Inst, Div Expt Oncol, Unit Urol, Milan, Italy.,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS San Raffaele Hospital, Milan, Italy (författare)

Patient-reported Side Effects 1 Year After Radical Prostatectomy or Radiotherapy for Prostate Cancer : A Register-based Nationwide Study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-533106
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533106URI
  • https://doi.org/10.1016/j.euo.2023.12.007DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223032URI
  • https://lup.lub.lu.se/record/ae76ad2e-73c8-401a-adae-ee145996bc66URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Data on functional and psychological side effects following curative treatment for prostate cancer are lacking from large, contemporary, unselected, populationbased cohorts. Objective: To assess urinary symptoms, bowel disturbances, erectile dysfunction (ED), and quality of life (QoL) 12 mo after robot -assisted radical prostatectomy (RARP) and radiotherapy (RT) using patient -reported outcome measures in the Swedish prostate cancer database. Design, setting, and participants: This was a nationwide, population -based, cohort study in Sweden of men who underwent primary RARP or RT between January 1, 2018 and December 31, 2020. Outcome measurements and statistical analysis: Absolute proportions and odds ratios (ORs) were calculated using multivariable logistic regression, with adjustment for clinical characteristics. Results and limitations: A total of 2557 men underwent RARP and 1741 received RT. Men who underwent RT were older (69 vs 65 yr) and had more comorbidities at baseline. After RARP, 13% of men experienced incontinence, compared to 6% after RT. The frequency of urinary bother was similar, at 18% after RARP and 18% after RT. Urgency to defecate was reported by 14% of men after RARP and 34% after RT. At 1 yr, 73% of men had ED after RARP, and 77% after RT. High QoL was reported by 85% of men after RARP and 78% of men after RT. On multivariable regression analysis, RT was associated with lower risks of urinary incontinence (OR 0.25, 95% confidence interval [CI] 0.19- 0.33), urinary bother (OR 0.79, 95% CI 0.66-0.95), and ED (OR 0.54, 95% CI 0.46-0.65), but higher risk of bowel symptoms (OR 2.86, 95% CI 2.42-3.39). QoL was higher after RARP than after RT (OR 1.34, 95% CI 1.12-1.61). Conclusions: Short-term specific side effects after curative treatment for prostate cancer significantly differed between RARP and RT in this large and unselected cohort. Nevertheless, the risk of urinary bother was lower after RT, while higher QoL was common after RARP. Patient summary: In our study of patients treated for prostate cancer, urinary bother and overall quality of life are comparable at 1 year after surgical removal of the prostate in comparison to radiotherapy, despite substantial differences in other side effects. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bergengren, OskarUppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)oskka588 (författare)
  • Carlsson, StefanKarolinska Univ Hosp, Dept Urol, Solna, Sweden.,Department of Urology, Karolinska University Hospital, Solna, Sweden (författare)
  • Garmo, HansUppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)hga27600 (författare)
  • Hjelm-Eriksson, MarieSt Goran Hosp, Dept Oncol, Stockholm, Sweden.,Department of Oncology, St. Göran Hospital, Stockholm, Sweden,Capio St. Görans Sjukhus (författare)
  • Fransson, PerUmeå University,Umeå universitet,Institutionen för omvårdnad,Cancercentrum, Norrlands University Hospital, Umeå, Sweden,Umeå Univ, Dept Nursing, Umeå, Sweden.;Norrlands Univ Hosp, Canc Ctr, Umeå, Sweden.(Swepub:umu)perfrn96 (författare)
  • Kindblom, JonUniv Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden.,Department of Oncology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (författare)
  • Robinson, DavidRyhov Hosp, Dept Urol, Jönköping, Sweden.,Department of Urology, Ryhov Hospital, Jönköping, Sweden,Ryhov County Hospital, Jönköping (författare)
  • Westerberg, Marcus,1990-Uppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)marwe776 (författare)
  • Stattin, PärUppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)parst892 (författare)
  • Carlsson, Sigrid V.University of Gothenburg,Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center,Mem Sloan Kettering Canc Ctr, Dept Surg Urol Serv, 1133 York Ave, New York, NY 10065 USA.;Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.;Gothenburg Univ, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden.;Lund Univ, Med Fac, Dept Translat Med, Div Urol Canc, Lund, Sweden.(Swepub:lu)si5270ca (författare)
  • Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Urology Oncology: Elsevier7:3, s. 605-6132588-9311

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