WFRF:(Eriksson Ulrika K)
Sökning: WFRF:(Eriksson Ulrika K) > Adhesion of human p...
- Eriksson, Andreas CLinköpings universitet,Farmakologi,Hälsouniversitetet (författare)
Adhesion of human platelets to albumin is synergistically increased by lysophosphatidic acid and adrenaline in a donor-dependent fashion
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
- Ovid Technologies (Wolters Kluwer Health),2006
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-13247
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13247URI
- https://doi.org/10.1097/01.mbc.0000233366.18605.b2DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Lysophosphatidic acid (LPA) and adrenaline are weak platelet activators considered important for thrombus formation, and were previously shown to synergistically increase platelet aggregation. Here we investigate synergistic activation by LPA and adrenaline when measuring platelet adhesion. Platelet-rich plasma from healthy blood donors together with adrenaline and/or LPA were added to protein-coated microplates. Platelets were allowed to adhere and the amount of adhesion detected enzymatically. The LPA and adrenaline combination induced a synergistic increase of platelet adhesion to a normally non-adhesive albumin surface. The degree of synergy varied markedly between individuals; these variations could not be explained by age, gender, blood type or different amounts of platelets, oxidized low-density lipoprotein, insulin or glucose in plasma. There was a trend indicating increased synergistic effect for platelets sensitive to adrenaline stimulation. The synergistic effect was blocked by the α2-adrenoceptor antagonist yohimbine and inhibited by the ADP scavenger system creatine phosphate/creatine phosphokinase and antibodies against αIIbβ3. Furthermore, platelets adhering to albumin after adrenaline and LPA treatment expressed P-selectin. In conclusion, LPA and adrenaline act synergistically to increase αIIbβ3-mediated platelet adhesion to albumin, dependent on α2-adrenoceptor signalling and platelet secretion. We also confirm that synergistic platelet activation achieved with LPA and adrenaline is highly donor dependent.
Ämnesord och genrebeteckningar
- adrenaline
- albumin
- lysophosphatidic acid
- platelet adhesion
- synergism
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Whiss, Per ALinköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)perwh53 (författare)
- Nilsson, Ulrika KLinköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)ulrni67 (författare)
- Linköpings universitetFarmakologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Blood Coagulation and Fibrinolysis: Ovid Technologies (Wolters Kluwer Health)17:5, s. 359-3680957-52351473-5733
Internetlänk
Hitta via bibliotek
- Blood Coagulation and Fibrinolysis (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Eriksson, Andrea ...
- Whiss, Per A
- Nilsson, Ulrika ...
- Artiklar i publikationen
- Blood Coagulatio ...
- Av lärosätet
- Linköpings universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
