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Sökning: WFRF:(Esteban Javier) > Thioredoxin 80-acti...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003896naa a2200517 4500
001oai:DiVA.org:umu-165147
003SwePub
008191112s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:121958400
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1651472 URI
0247 a https://doi.org/10.1371/journal.pone.00169602 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1219584002 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cortes-Bratti, Ximena4 aut
2451 0a Thioredoxin 80-activated-monocytes (TAMs) inhibit the replication of intracellular pathogens
264 c 2011-02-18
264 1b Public Library Science,c 2011
338 a print2 rdacarrier
520 a BACKGROUND: Thioredoxin 80 (Trx80) is an 80 amino acid natural cleavage product of Trx, produced primarily by monocytes. Trx80 induces differentiation of human monocytes into a novel cell type, named Trx80-activated-monocytes (TAMs).PRINCIPAL FINDINGS: In this investigation we present evidence for a role of TAMs in the control of intracellular bacterial infections. As model pathogens we have chosen Listeria monocytogenes and Brucella abortus which replicate in the cytosol and the endoplasmic reticulum respectively. Our data indicate that TAMs efficiently inhibit intracellular growth of both L. monocytogenes and B. abortus. Further analysis shows that Trx80 activation prevents the escape of GFP-tagged L. monocytogenes into the cytosol, and induces accumulation of the bacteria within the lysosomes. Inhibition of the lysosomal activity by chloroquine treatment resulted in higher replication of bacteria in TAMs compared to that observed in control cells 24 h post-infection, indicating that TAMs kill bacteria by preventing their escape from the endosomal compartments, which progress into a highly degradative phagolysosome.SIGNIFICANCE: Our results show that Trx80 potentiates the bactericidal activities of professional phagocytes, and contributes to the first line of defense against intracellular bacteria.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Bassères, Eugénie4 aut
7001 a Herrera-Rodriguez, Fabiola4 aut
7001 a Botero-Kleiven, Silvia4 aut
7001 a Coppotelli, Giuseppeu Karolinska Institutet4 aut
7001 a Andersen, Jens B4 aut
7001 a Masucci, Maria Gu Karolinska Institutet4 aut
7001 a Holmgren, Arneu Karolinska Institutet4 aut
7001 a Chaves-Olarte, Esteban4 aut
7001 a Frisan, Teresa,d 1967-u Karolinska Institutet4 aut0 (Swepub:umu)tefr0009
7001 a Avila-Cariño, Javieru Karolinska Institutet4 aut
7102 a Karolinska Institutet4 org
7730 t PLOS ONEd : Public Library Scienceg 6:2q 6:2x 1932-6203
8564 u https://doi.org/10.1371/journal.pone.0016960y Fulltext
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016960&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165147
8564 8u https://doi.org/10.1371/journal.pone.0016960
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:121958400

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