Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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Fältnamn	Indikatorer	Metadata
000		08723naa a2202293 4500
001		oai:DiVA.org:uu-174593
003		SwePub
008		120522s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1745932 URI
024	7	a https://doi.org/10.1371/journal.pgen.10025842 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Pattaro, Cristian4 aut
245	1 0	a Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
264		c 2012-03-29
264	1	b Public Library of Science (PLoS),c 2012
338		a electronic2 rdacarrier
520		a Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Koettgen, Anna4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Garnaas, Maija4 aut
700	1	a Boeger, Carsten A.4 aut
700	1	a Fuchsberger, Christian4 aut
700	1	a Olden, Matthias4 aut
700	1	a Chen, Ming-Huei4 aut
700	1	a Tin, Adrienne4 aut
700	1	a Taliun, Daniel4 aut
700	1	a Li, Man4 aut
700	1	a Gao, Xiaoyi4 aut
700	1	a Gorski, Mathias4 aut
700	1	a Yang, Qiong4 aut
700	1	a Hundertmark, Claudia4 aut
700	1	a Foster, Meredith C.4 aut
700	1	a O'Seaghdha, Conall M.4 aut
700	1	a Glazer, Nicole4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Liu, Ching-Ti4 aut
700	1	a Smith, Albert V.4 aut
700	1	a O'Connell, Jeffrey R.4 aut
700	1	a Struchalin, Maksim4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Li, Guo4 aut
700	1	a Johnson, Andrew D.4 aut
700	1	a Gierman, Hinco J.4 aut
700	1	a Feitosa, Mary4 aut
700	1	a Hwang, Shih-Jen4 aut
700	1	a Atkinson, Elizabeth J.4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Cornelis, Marilyn C.4 aut
700	1	a Johansson, Åsau Uppsala universitet,Genomik,Gyllensten4 aut0 (Swepub:uu)asjoh108
700	1	a Toenjes, Anke4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Chouraki, Vincent4 aut
700	1	a Holliday, Elizabeth G.4 aut
700	1	a Sorice, Rossella4 aut
700	1	a Kutalik, Zoltan4 aut
700	1	a Lehtimaeki, Terho4 aut
700	1	a Esko, Tonu4 aut
700	1	a Deshmukh, Harshal4 aut
700	1	a Ulivi, Sheila4 aut
700	1	a Chu, Audrey Y.4 aut
700	1	a Murgia, Federico4 aut
700	1	a Trompet, Stella4 aut
700	1	a Imboden, Medea4 aut
700	1	a Kollerits, Barbara4 aut
700	1	a Pistis, Giorgio4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Aspelund, Thor4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Mitchell, Braxton D.4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Schmidt, Helena4 aut
700	1	a Cavalieri, Margherita4 aut
700	1	a Rao, Madhumathi4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Demirkan, Ayse4 aut
700	1	a Oostra, Ben A.4 aut
700	1	a de Andrade, Mariza4 aut
700	1	a Turner, Stephen T.4 aut
700	1	a Ding, Jingzhong4 aut
700	1	a Andrews, Jeanette S.4 aut
700	1	a Freedman, Barry I.4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Illig, Thomas4 aut
700	1	a Doering, Angela4 aut
700	1	a Wichmann, H. -Erich4 aut
700	1	a Kolcic, Ivana4 aut
700	1	a Zemunik, Tatijana4 aut
700	1	a Boban, Mladen4 aut
700	1	a Minelli, Cosetta4 aut
700	1	a Wheeler, Heather E.4 aut
700	1	a Igl, Wilmaru Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
700	1	a Zaboli, Ghazalu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
700	1	a Wild, Sarah H.4 aut
700	1	a Wright, Alan F.4 aut
700	1	a Campbell, Harry4 aut
700	1	a Ellinghaus, David4 aut
700	1	a Nothlings, Ute4 aut
700	1	a Jacobs, Gunnar4 aut
700	1	a Biffar, Reiner4 aut
700	1	a Endlich, Karlhans4 aut
700	1	a Ernst, Florian4 aut
700	1	a Homuth, Georg4 aut
700	1	a Kroemer, Heyo K.4 aut
700	1	a Nauck, Matthias4 aut
700	1	a Stracke, Sylvia4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Kovacs, Peter4 aut
700	1	a Stumvoll, Michael4 aut
700	1	a Magi, Reedik4 aut
700	1	a Hofman, Albert4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Aulchenko, Yurii S.4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Hastie, Nick4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Helmer, Catherine4 aut
700	1	a Wang, Jie Jin4 aut
700	1	a Ruggiero, Daniela4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Kaehoenen, Mika4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Nikopensius, Tiit4 aut
700	1	a Province, Michael4 aut
700	1	a Ketkar, Shamika4 aut
700	1	a Colhoun, Helen4 aut
700	1	a Doney, Alex4 aut
700	1	a Robino, Antonietta4 aut
700	1	a Giulianini, Franco4 aut
700	1	a Kraemer, Bernhard K.4 aut
700	1	a Portas, Laura4 aut
700	1	a Ford, Ian4 aut
700	1	a Buckley, Brendan M.4 aut
700	1	a Adam, Martin4 aut
700	1	a Thun, Gian-Andri4 aut
700	1	a Paulweber, Bernhard4 aut
700	1	a Haun, Margot4 aut
700	1	a Sala, Cinzia4 aut
700	1	a Metzger, Marie4 aut
700	1	a Mitchell, Paul4 aut
700	1	a Ciullo, Marina4 aut
700	1	a Kim, Stuart K.4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Metspalu, Andres4 aut
700	1	a Palmer, Colin4 aut
700	1	a Gasparini, Paolo4 aut
700	1	a Pirastu, Mario4 aut
700	1	a Jukema, J. Wouter4 aut
700	1	a Probst-Hensch, Nicole M.4 aut
700	1	a Kronenberg, Florian4 aut
700	1	a Toniolo, Daniela4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Shuldiner, Alan R.4 aut
700	1	a Coresh, Josef4 aut
700	1	a Schmidt, Reinhold4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Siscovick, David S.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Borecki, Ingrid4 aut
700	1	a Kardia, Sharon L. R.4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Curhan, Gary C.4 aut
700	1	a Rudan, Igor4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Genomik,Gyllensten4 aut0 (Swepub:uu)ulfgyll
700	1	a Wilson, James F.4 aut
700	1	a Franke, Andre4 aut
700	1	a Pramstaller, Peter P.4 aut
700	1	a Rettig, Rainer4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Ridker, Paul4 aut
700	1	a Parsa, Afshin4 aut
700	1	a Bochud, Murielle4 aut
700	1	a Heid, Iris M.4 aut
700	1	a Goessling, Wolfram4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Kao, W. H. Linda4 aut
700	1	a Fox, Caroline S.4 aut
710	2	a Uppsala universitetb Genomik4 org
773	0	t PLoS Geneticsd : Public Library of Science (PLoS)g 8:3, s. e1002584-q 8:3<e1002584-x 1553-7390x 1553-7404
856	4	u https://uu.diva-portal.org/smash/get/diva2:529175/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002584&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174593
856	4 8	u https://doi.org/10.1371/journal.pgen.1002584

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Av författaren/redakt...: Pattaro, Cristia ...; Koettgen, Anna; Teumer, Alexande ...; Garnaas, Maija; Boeger, Carsten ...; Fuchsberger, Chr ...; visa fler...; Olden, Matthias; Chen, Ming-Huei; Tin, Adrienne; Taliun, Daniel; Li, Man; Gao, Xiaoyi; Gorski, Mathias; Yang, Qiong; Hundertmark, Cla ...; Foster, Meredith ...; O'Seaghdha, Cona ...; Glazer, Nicole; Isaacs, Aaron; Liu, Ching-Ti; Smith, Albert V.; O'Connell, Jeffr ...; Struchalin, Maks ...; Tanaka, Toshiko; Li, Guo; Johnson, Andrew ...; Gierman, Hinco J ...; Feitosa, Mary; Hwang, Shih-Jen; Atkinson, Elizab ...; Lohman, Kurt; Cornelis, Marily ...; Johansson, Åsa; Toenjes, Anke; Dehghan, Abbas; Chouraki, Vincen ...; Holliday, Elizab ...; Sorice, Rossella; Kutalik, Zoltan; Lehtimaeki, Terh ...; Esko, Tonu; Deshmukh, Harsha ...; Ulivi, Sheila; Chu, Audrey Y.; Murgia, Federico; Trompet, Stella; Imboden, Medea; Kollerits, Barba ...; Pistis, Giorgio; Harris, Tamara B ...; Launer, Lenore J ...; Aspelund, Thor; Eiriksdottir, Gu ...; Mitchell, Braxto ...; Boerwinkle, Eric; Schmidt, Helena; Cavalieri, Margh ...; Rao, Madhumathi; Hu, Frank B.; Demirkan, Ayse; Oostra, Ben A.; de Andrade, Mari ...; Turner, Stephen ...; Ding, Jingzhong; Andrews, Jeanett ...; Freedman, Barry ...; Koenig, Wolfgang; Illig, Thomas; Doering, Angela; Wichmann, H. -Er ...; Kolcic, Ivana; Zemunik, Tatijan ...; Boban, Mladen; Minelli, Cosetta; Wheeler, Heather ...; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H.; Wright, Alan F.; Campbell, Harry; Ellinghaus, Davi ...; Nothlings, Ute; Jacobs, Gunnar; Biffar, Reiner; Endlich, Karlhan ...; Ernst, Florian; Homuth, Georg; Kroemer, Heyo K.; Nauck, Matthias; Stracke, Sylvia; Voelker, Uwe; Voelzke, Henry; Kovacs, Peter; Stumvoll, Michae ...; Magi, Reedik; Hofman, Albert; Uitterlinden, An ...; Rivadeneira, Fer ...; Aulchenko, Yurii ...; Polasek, Ozren; Hastie, Nick; Vitart, Veroniqu ...; Helmer, Catherin ...; Wang, Jie Jin; Ruggiero, Daniel ...; Bergmann, Sven; Kaehoenen, Mika; Viikari, Jorma; Nikopensius, Tii ...; Province, Michae ...; Ketkar, Shamika; Colhoun, Helen; Doney, Alex; Robino, Antoniet ...; Giulianini, Fran ...; Kraemer, Bernhar ...; Portas, Laura; Ford, Ian; Buckley, Brendan ...; Adam, Martin; Thun, Gian-Andri; Paulweber, Bernh ...; Haun, Margot; Sala, Cinzia; Metzger, Marie; Mitchell, Paul; Ciullo, Marina; Kim, Stuart K.; Vollenweider, Pe ...; Raitakari, Olli; Metspalu, Andres; Palmer, Colin; Gasparini, Paolo; Pirastu, Mario; Jukema, J. Woute ...; Probst-Hensch, N ...; Kronenberg, Flor ...; Toniolo, Daniela; Gudnason, Vilmun ...; Shuldiner, Alan ...; Coresh, Josef; Schmidt, Reinhol ...; Ferrucci, Luigi; Siscovick, David ...; van Duijn, Corne ...; Borecki, Ingrid; Kardia, Sharon L ...; Liu, Yongmei; Curhan, Gary C.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Franke, Andre; Pramstaller, Pet ...; Rettig, Rainer; Prokopenko, Inga; Witteman, Jacque ...; Hayward, Carolin ...; Ridker, Paul; Parsa, Afshin; Bochud, Murielle; Heid, Iris M.; Goessling, Wolfr ...; Chasman, Daniel ...; Kao, W. H. Linda; Fox, Caroline S.; visa färre...

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