Genomic analyses of Francisella tularensis strains confirm disease transmission from drinking water sources, Turkey, 2008, 2009 and 2012

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Fältnamn	Indikatorer	Metadata
000		03010naa a2200397 4500
001		oai:DiVA.org:umu-106504
003		SwePub
008		150714s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1065042 URI
024	7	a https://doi.org/10.2807/1560-7917.ES2015.20.21.211362 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Karadenizli, A.4 aut
245	1 0	a Genomic analyses of Francisella tularensis strains confirm disease transmission from drinking water sources, Turkey, 2008, 2009 and 2012
264	1	c 2015
338		a print2 rdacarrier
520		a Waterborne epidemics of tularaemia caused by Francisella tularensis are increasingly reported in Turkey. We have used whole genome sequencing to investigate if F. tularensis isolated from patients could be traced back to drinking water sources. Tonsil swabs from 33 patients diagnosed with oropharyngeal tularaemia in three outbreaks and 140 water specimens were analysed. F. tularensis subsp. holarctica was confirmed by microagglutination and PCR in 12 patients and five water specimens. Genomic analysis of three pairs of patient and water isolates from outbreaks in Sivas, Corum, and Kocaeli showed the isolates to belong to two new clusters of the F. tularensis B. 12 genetic clade. The clusters were defined by 19 and 15 single nucleotide polymorphisms (SNPs) in a multiple alignment based on 507 F. tularensis genomes. One synonymous SNP was chosen as a new canonical SNP (canSNP) for each cluster for future use in diagnostic assays. No SNP was identified between the genomes from the patient-water pair of isolates from Kocaeli, one SNP between the pair of isolates from Sivas, whereas the pair from Corum differed at seven SNPs. These results illustrate the power of whole genome sequencing for tracing F. tularensis patient isolates back to their environmental source.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Forsman, M.4 aut
700	1	a Simsek, H.4 aut
700	1	a Taner, M.4 aut
700	1	a Ohrman, C.4 aut
700	1	a Myrtennas, K.4 aut
700	1	a Larkeryd, A.4 aut
700	1	a Johansson, Andersu Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)4 aut0 (Swepub:umu)anjo0135
700	1	a Ozdemir, L.4 aut
700	1	a Sjodin, A.4 aut
710	2	a Umeå universitetb Institutionen för klinisk mikrobiologi4 org
773	0	t Eurosurveillanceg 20:21q 20:21x 1025-496Xx 1560-7917
856	4	u http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21136y Fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106504
856	4 8	u https://doi.org/10.2807/1560-7917.ES2015.20.21.21136

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Av författaren/redakt...: Karadenizli, A.; Forsman, M.; Simsek, H.; Taner, M.; Ohrman, C.; Myrtennas, K.; visa fler...; Larkeryd, A.; Johansson, Ander ...; Ozdemir, L.; Sjodin, A.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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Av lärosätet: Umeå universitet

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