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Predictors of ASDAS...
Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration
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- Ørnbjerg, L. M. (author)
- Copenhagen University Hospital
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Linde, L. (author)
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- Georgiadis, S. (author)
- Copenhagen University Hospital
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- Rasmussen, S. H. (author)
- Copenhagen University Hospital,Portuguese Institute of Rheumatology,NOVA University Lisbon
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- Lindström, Ulf (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Askling, J. (author)
- Karolinska Institute,Karolinska Institutet
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- Michelsen, B. (author)
- Sørlandet Hospital,Copenhagen University Hospital,Diakonhjemmet Hospital
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- Giuseppe, D. D. (author)
- Karolinska Institute,Karolinska Institutet
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- Wallman, Johan K. (author)
- Lund University,Lunds universitet,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Pavelka, K. (author)
- Charles University in Prague,Institute of Rheumatology, Prague
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- Závada, J. (author)
- Charles University in Prague,Institute of Rheumatology, Prague
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- Nissen, M. J. (author)
- Geneva University Hospital
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- Jones, G. T. (author)
- University of Aberdeen
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- Relas, H. (author)
- Helsinki University Central Hospital
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- Pirilä, L. (author)
- University of Turku,Turku University Hospital
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- Tomšič, M. (author)
- University Medical Centre Ljubljana,University of Ljubljana
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- Rotar, Z. (author)
- University Medical Centre Ljubljana,University of Ljubljana
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- Geirsson, A. J. (author)
- National University Hospital of Iceland
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- Gudbjornsson, B. (author)
- National University Hospital of Iceland,University of Iceland
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- Kristianslund, E. K. (author)
- Diakonhjemmet Hospital
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- van sder Horst-Bruinsma, I. (author)
- Radboud University Medical Center
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- Loft, A. G. (author)
- Aarhus University,Aarhus University Hospital
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- Laas, K. (author)
- East Tallinn Central Hospital
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- Iannone, F. (author)
- University of Bari Aldo Moro
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- Corrado, A. (author)
- University of Foggia
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- Ciurea, A. (author)
- University Hospital of Zurich
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- Santos, M. J. (author)
- Hospital Garcia de Orta
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Santos, H. (author)
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- Codreanu, C. (author)
- Carol Davila University of Medicine and Pharmacy
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- Akkoc, N. (author)
- Celal Bayar University Hospital
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- Gunduz, O. S. (author)
- Celal Bayar University Hospital
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- Glintborg, B. (author)
- University of Copenhagen,Copenhagen University Hospital
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- Østergaard, M. (author)
- University of Copenhagen,Copenhagen University Hospital
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- Hetland, M. L. (author)
- University of Copenhagen,Copenhagen University Hospital
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Seminars in Arthritis and Rheumatism. - : Elsevier BV. - 0049-0172 .- 1532-866X. ; 56
- Related links:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Methods: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data. Results: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97–0.98), men vs. women: 1.88 (1.60–2.22), current vs. non-smoking: 0.76 (0.63–0.91), HLA-B27 positive vs. negative: 1.51 (1.20–1.91), TNF start year 2015–2018 vs. 2009–2014: 1.24 (1.06–1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25–1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58–1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99–1.00) and 0.99 (0.99–1.99), respectively Conclusion: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Ankylosing spondylitis disease activity score
- Axial spondyloarthritis
- Predictors
- TNF-inhibitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ørnbjerg, L. M.
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Linde, L.
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Georgiadis, S.
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Rasmussen, S. H.
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Lindström, Ulf
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Askling, J.
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show more...
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Michelsen, B.
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Giuseppe, D. D.
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Wallman, Johan K ...
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Pavelka, K.
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Závada, J.
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Nissen, M. J.
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Jones, G. T.
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Relas, H.
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Pirilä, L.
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Tomšič, M.
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Rotar, Z.
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Geirsson, A. J.
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Gudbjornsson, B.
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Kristianslund, E ...
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van sder Horst-B ...
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Loft, A. G.
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Laas, K.
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Iannone, F.
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Corrado, A.
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Ciurea, A.
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Santos, M. J.
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Santos, H.
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Codreanu, C.
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Akkoc, N.
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Gunduz, O. S.
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Glintborg, B.
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Østergaard, M.
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Hetland, M. L.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Seminars in Arth ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Lund University