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Lung transplantatio...
Lung transplantation for sarcoidosis: outcome and prognostic factors
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Le Pavec, J. M. (author)
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Valeyre, D. (author)
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Gazengel, P. (author)
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Holm, A. M. (author)
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Schultz, H. H. (author)
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Perch, M. (author)
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Le Borgne, A. (author)
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Reynaud-Gaubert, M. (author)
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Knoop, C. (author)
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Godinas, L. (author)
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Hirschi, S. (author)
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Bunel, V. (author)
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Laporta, R. (author)
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Harari, S. (author)
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Blanchard, E. (author)
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- Magnusson, Jesper (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Tissot, A. (author)
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Picard, C. (author)
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Savale, L. (author)
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Bernaudin, J. F. (author)
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Brillet, P. Y. (author)
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Nunes, H. (author)
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Humbert, M. (author)
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Fadel, E. (author)
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Gottlieb, J. (author)
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(creator_code:org_t)
- 2021-01-21
- 2021
- English.
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In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 58:2
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Study question In patients with sarcoidosis, past and ongoing immunosuppressive regimens, recurrent disease in the transplant and extrapulmonary involvement may affect outcomes of lung transplantation. We asked whether sarcoidosis lung phenotypes can be differentiated and, if so, how they relate to outcomes in patients with pulmonary sarcoidosis treated by lung transplantation. Patients and methods We retrospectively reviewed data from 112 patients who met international diagnostic criteria for sarcoidosis and underwent lung or heart-lung transplantation between 2006 and 2019 at 16 European centres. Results Patient survival was the main outcome measure. At transplantation, median (interaquartile range (IQR)) age was 52 (46-59) years; 71 (64%) were male. Lung phenotypes were individualised as follows: 1) extended fibrosis only; 2) airflow obstruction; 3) severe pulmonary hypertension (sPH) and airflow obstruction; 4) sPH, airflow obstruction and fibrosis; 5) sPH and fibrosis; 6) airflow obstruction and fibrosis; 7) sPH; and 8) none of these criteria, in 17%, 16%, 17%, 14%, 11%, 9%, 5% and 11% of patients, respectively. Post-transplant survival rates after 1, 3, and 5 years were 86%, 76% and 69%, respectively. During follow-up (median (IQR) 46 (16-89) months), 31% of patients developed chronic lung allograft dysfunction. Age and extended lung fibrosis were associated with increased mortality. Pulmonary fibrosis predominating peripherally was associated with short-term complications. Answer to the study question Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- pulmonary-hypertension
- international society
- recurrence
- heart
- granulomas
- management
- allografts
- survival
- disease
- Respiratory System
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Le Pavec, J. M.
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Valeyre, D.
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Gazengel, P.
-
Holm, A. M.
-
Schultz, H. H.
-
Perch, M.
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show more...
-
Le Borgne, A.
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Reynaud-Gaubert, ...
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Knoop, C.
-
Godinas, L.
-
Hirschi, S.
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Bunel, V.
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Laporta, R.
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Harari, S.
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Blanchard, E.
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Magnusson, Jespe ...
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Tissot, A.
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Picard, C.
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Savale, L.
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Bernaudin, J. F.
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Brillet, P. Y.
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Nunes, H.
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Humbert, M.
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Fadel, E.
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Gottlieb, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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European Respira ...
- By the university
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University of Gothenburg