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A Meta-analysis of ...
A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
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- Travis, Ruth C. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
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- Appleby, Paul N. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Martin, Richard M. (author)
- Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.;Univ Bristol, MRC, Univ Bristol Integrat Epidemiol Unit, Bristol, Avon, England.;Natl Inst Hlth Res Bristol, Biomed Res Unit Nutr, Bristol, Avon, England.
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- Holly, Jeff M. P. (author)
- Univ Bristol, Fac Med, Sch Clin Sci, Bristol, Avon, England.
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- Albanes, Demetrius (author)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Black, Amanda (author)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Bueno-de-Mesquita, H. Bas (author)
- Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
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- Chan, June M. (author)
- Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Urol, San Francisco, CA USA.
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- Chen, Chu (author)
- Univ Oxford, Nuffield Dept Surg, Oxford, England.
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- Chirlaque, Maria-Dolores (author)
- IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;CIBER Epidemiol & Salud Publ, Madrid, Spain.
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- Cook, Michael B. (author)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Deschasaux, Melanie (author)
- Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
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- Donovan, Jenny L. (author)
- Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
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- Ferrucci, Luigi (author)
- NIA, Intramural Res Program, Baltimore, MD 21224 USA.
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- Galan, Pilar (author)
- Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
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- Giles, Graham G. (author)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.,NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Giovannucci, Edward L. (author)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Med, 665 Huntington Ave, Boston, MA 02115 USA.
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- Gunter, Marc J. (author)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
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- Habel, Laurel A. (author)
- Kaiser Permanente No Calif, Div Res, Oakland, CA USA.
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Hamdy, Freddie C. (author)
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- Helzlsouer, Kathy J. (author)
- St Johns Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA.
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- Hercberg, Serge (author)
- Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
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- Hoover, Robert N. (author)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Janssen, Joseph A. M. J. L. (author)
- Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.,Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
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- Kaaks, Rudolf (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
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- Kubo, Tatsuhiko (author)
- Univ Occupat & Environm Hlth, Kitakyushu, Fukuoka 807, Japan.
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Le Marchand, Loic (author)
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- Metter, E. Jeffrey (author)
- NIA, Intramural Res Program, Baltimore, MD 21224 USA.;Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA.
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- Mikami, Kazuya (author)
- Kyoto Prefectural Univ Med, Kyoto, Japan.
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- Morris, Joan K. (author)
- Queen Mary Univ London, Wolfson Inst Prevent Med, Charterhouse Sq, London, England.
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- Neal, David E. (author)
- Univ Cambridge, Dept Oncol, Cambridge, England.
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- Neuhouser, Marian L. (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
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- Ozasa, Kotaro (author)
- Radiat Effects Res Fdn, Hiroshima, Japan.
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- Palli, Domenico (author)
- Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy.
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- Platz, Elizabeth A. (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Pollak, Michael N. (author)
- McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.
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- Price, Alison J. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Roobol, Monique J. (author)
- Erasmus MC, Dept Urol, Rotterdam, Netherlands.
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- Schaefer, Catherine (author)
- Kaiser Permanente No Calif, Div Res, Oakland, CA USA.
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- Schenk, Jeannette M. (author)
- Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
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- Severi, Gianluca (author)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Human Genet Fdn, Turin, Italy.
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- Stampfer, Meir J. (author)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA.
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- Stattin, Pär (author)
- Uppsala universitet,Umeå universitet,Urologi och andrologi,Univ Uppsala Hosp, Dept Surg Sci, Uppsala, Sweden,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.
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- Tamakoshi, Akiko (author)
- Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan.
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- Tangen, Catherine M. (author)
- Univ Washington, Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98195 USA.;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
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- Touvier, Mathilde (author)
- Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
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- Wald, Nicholas J. (author)
- Queen Mary Univ London, Wolfson Inst Prevent Med, Charterhouse Sq, London, England.
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- Weiss, Noel S. (author)
- Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
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Ziegler, Regina G. (author)
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- Key, Timothy J. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Allen, Naomi E. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England.
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Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA. (creator_code:org_t)
- 2016
- 2016
- English.
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In: Cancer Research. - 0008-5472 .- 1538-7445. ; 76:8, s. 2288-2300
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (P-trend all <= 0.005), and IGFBP-1 was inversely associated weakly with risk (P-trend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (P-heterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, P-heterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Prostatic Neoplasms
- Cross-Sectional Studies
- IGF
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Travis, Ruth C.
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Appleby, Paul N.
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Martin, Richard ...
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Holly, Jeff M. P ...
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Albanes, Demetri ...
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Black, Amanda
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show more...
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Bueno-de-Mesquit ...
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Chan, June M.
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Chen, Chu
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Chirlaque, Maria ...
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Cook, Michael B.
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Deschasaux, Mela ...
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Donovan, Jenny L ...
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Ferrucci, Luigi
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Galan, Pilar
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Giles, Graham G.
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Giovannucci, Edw ...
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Gunter, Marc J.
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Habel, Laurel A.
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Hamdy, Freddie C ...
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Helzlsouer, Kath ...
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Hercberg, Serge
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Hoover, Robert N ...
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Janssen, Joseph ...
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Kaaks, Rudolf
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Kubo, Tatsuhiko
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Le Marchand, Loi ...
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Metter, E. Jeffr ...
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Mikami, Kazuya
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Morris, Joan K.
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Neal, David E.
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Neuhouser, Maria ...
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Ozasa, Kotaro
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Palli, Domenico
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Platz, Elizabeth ...
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Pollak, Michael ...
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Price, Alison J.
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Roobol, Monique ...
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Schaefer, Cather ...
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Schenk, Jeannett ...
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Severi, Gianluca
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Stampfer, Meir J ...
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Stattin, Pär
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Tamakoshi, Akiko
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Tangen, Catherin ...
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Touvier, Mathild ...
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Wald, Nicholas J ...
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Weiss, Noel S.
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Ziegler, Regina ...
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Key, Timothy J.
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Allen, Naomi E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Research
- By the university
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Umeå University
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Uppsala University