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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003942naa a2200433 4500
001oai:gup.ub.gu.se/147462
003SwePub
008240528s2011 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1474622 URI
0247 a https://doi.org/10.1002/ana.224892 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Favrais, Géraldine4 aut
2451 0a Systemic inflammation disrupts the developmental program of white matter.
264 c 2011-07-27
264 1b Wiley,c 2011
520 a OBJECTIVE: Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the developing brain. However, these studies do not offer detailed pathophysiological mechanisms, and they rely on relatively severe infectious or inflammatory stimuli that most likely do not reflect the levels of systemic inflammation observed in many human preterm infants. The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development. METHODS: Newborn mice received twice-daily intraperitoneal injections of interleukin-1β (IL-1β) over 5 days and were studied for myelination, oligodendrogenesis, and behavior and with magnetic resonance imaging (MRI). RESULTS: Mice exposed to IL-1β had a long-lasting myelination defect that was characterized by an increased number of nonmyelinated axons. They also displayed a reduction of the diameter of the myelinated axons. In addition, IL-1β induced a significant reduction of the density of myelinating oligodendrocytes accompanied by an increased density of oligodendrocyte progenitors, suggesting a partial blockade in the oligodendrocyte maturation process. Accordingly, IL-1β disrupted the coordinated expression of several transcription factors known to control oligodendrocyte maturation. These cellular and molecular abnormalities were correlated with a reduced white matter fractional anisotropy on diffusion tensor imaging and with memory deficits. INTERPRETATION: Moderate perinatal systemic inflammation alters the developmental program of the white matter. This insult induces a long-lasting myelination deficit accompanied by cognitive defects and MRI abnormalities, further supporting the clinical relevance of the present data. ANN NEUROL 2011.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a van de Looij, Yohan4 aut
7001 a Fleiss, Bobbiu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xflebo
7001 a Ramanantsoa, Nelina4 aut
7001 a Bonnin, Philippe4 aut
7001 a Stoltenburg-Didinger, Gisela4 aut
7001 a Lacaud, Adrien4 aut
7001 a Saliba, Elie4 aut
7001 a Dammann, Olaf4 aut
7001 a Gallego, Jorge4 aut
7001 a Sizonenko, Stéphane4 aut
7001 a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xhaghe
7001 a Lelièvre, Vincent4 aut
7001 a Gressens, Pierre4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org
7730 t Annals of neurologyd : Wileyg 70:4, s. 550-565q 70:4<550-565x 1531-8249x 0364-5134
8564 8u https://gup.ub.gu.se/publication/147462
8564 8u https://doi.org/10.1002/ana.22489

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