Exhalation profile and elimination kinetics of mouth alcohol

Grubb, David (author): Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

Lindberg, Lars (author): Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

(creator_code:org_t)

Abstract Subject headings

Mouth alcohol (MA) is a potential source of error in alcohol breath-testing. Although utilized commercially for MA-detection, the exhalation profile of breath samples containing MA has not been systematically studied before. To characterize the exhalation profile of MA, volumetric expirograms of single-exhalations containing MA were examined. In addition, to explain reports of unusual slow elimination of MA and a suggested influence of blood alcohol on MA elimination, we tested whether MA is distributed to a second compartment by mathematical modelling. Eight subjects rinsed their mouths with alcohol without swallowing, before and after alcohol were administered directly into their stomachs. Breath samples were provided through a low airflow-restricted mouth piece into an analyzer with a sampling frequency of 33 Hz. Mouth alcohol caused an early concentration peak in air from the oral cavity, followed by a continuous contamination of the passing deep lung air which, at the end of the exhalation, exhibited a second, late, concentration peak. In the presence of blood alcohol, however, the distinctive peak features of the profile were absent despite that the breath samples contained MA, making the exhalation profile an unreliable tool for MA detection. Mouth alcohol is probably not distributed to a second compartment to an extent that is of any forensic importance.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Anesthesiology a ...

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