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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 32831naa a2202785 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:143700177 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-412969 | |
| 009 | oai:lup.lub.lu.se:a18bfc6d-b006-4e66-af62-78b53b51633e | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1437001772 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-020-1965-x2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4129692 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/a18bfc6d-b006-4e66-af62-78b53b51633e2 URI |
| 040 | a (SwePub)kid (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rheinbay, Eu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Broad Institute4 aut |
| 245 | 1 0 | a Analyses of non-coding somatic drivers in 2,658 cancer whole genomes |
| 264 | c 2020-02-05 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a The discovery of drivers of cancer has traditionally focused on protein-coding genes1–4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers6,7, raise doubts about others and identify novel candidates, including point mutations in the 5′ region of TP53, in the 3′ untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a DNA Breaks | |
| 653 | a Databases, Genetic | |
| 653 | a Gene Expression Regulation, Neoplastic | |
| 653 | a Genome, Human/genetics | |
| 653 | a Genome-Wide Association Study | |
| 653 | a Humans | |
| 653 | a INDEL Mutation | |
| 653 | a Mutation/genetics | |
| 653 | a Neoplasms/genetics | |
| 700 | 1 | a Nielsen, MMu Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Dana Farber Canc Inst, Boston, MA 02115 USA.;Univ Bern, Univ Hosp, Dept Med Oncol, Bern, Switzerland.;Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia.,Aarhus University Hospital4 aut |
| 700 | 1 | a Abascal, Fu Wellcome Trust Sanger Inst, Hinxton, England.,European Mol Biol Lab, European Bioinformat Inst, Hinxton, England.,Wellcome Trust Sanger Institute,European Bioinformatics Institute4 aut |
| 700 | 1 | a Wala, JAu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Univ, Bioinformat & Integrat Genom, Cambridge, MA 02138 USA.,Broad Institute4 aut |
| 700 | 1 | a Shapira, Ou Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.,Broad Institute4 aut |
| 700 | 1 | a Tiao, Gu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.,Broad Institute4 aut |
| 700 | 1 | a Hornshoj, Hu Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Johns Hopkins Sch Med, Baltimore, MD USA.,Aarhus University Hospital4 aut |
| 700 | 1 | a Hess, JMu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.,Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Broad Institute,Aarhus University Hospital4 aut |
| 700 | 1 | a Juul, RIu Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Aarhus University Hospital4 aut |
| 700 | 1 | a Lin, Zu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Univ, Cambridge, MA 02138 USA.,Broad Institute4 aut |
| 700 | 1 | a Feuerbach, Lu German Canc Res Ctr, Div Appl Bioinformat, Heidelberg, Germany.,German Cancer Research Centre4 aut |
| 700 | 1 | a Sabarinathan, Ru Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.,Barcelona Institute of Science and Technology4 aut |
| 700 | 1 | a Madsen, Tu Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Univ Santiago de Compostela, Dept Zool Genet & Phys Anthropol, Santiago De Compostela, Spain.;Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Santiago De Compostela, Spain.;Univ Vigo, Biomed Res Ctr CINBIO, Vigo, Spain.,Aarhus University Hospital4 aut |
| 700 | 1 | a Kim, Ju Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.,Natl Canc Ctr Korea, Res Core Ctr, Goyang Si, South Korea.,Broad Institute4 aut |
| 700 | 1 | a Mularoni, Lu Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.,Barcelona Institute of Science and Technology4 aut |
| 700 | 1 | a Shuai, Su Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.;Ontario Inst Canc Res, Toronto, ON, Canada.,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.,Simon Fraser Univ, Burnaby, BC, Canada.;Vancouver Prostate Ctr, Vancouver, BC, Canada.;Indiana Univ, Bloomington, IN USA.,Ontario Institute for Cancer Research4 aut |
| 700 | 1 | a Lanzos, Au Univ Bern, Dept BioMed Res, Bern, Switzerland.;Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland.;Univ Bern, Bern Univ Hosp, Dept Med Oncol, Bern, Switzerland.,Bern University Hospital4 aut |
| 700 | 1 | a Herrmann, Cu German Canc Res Ctr, Div Theoret Bioinformat, Heidelberg, Germany.;Heidelberg Univ, Bioquant Ctr, Inst Pharm & Mol Biotechnol, Heidelberg, Germany.,German Cancer Research Centre4 aut |
| 700 | 1 | a Maruvka, YEu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.,Broad Institute4 aut |
| 700 | 1 | a Shen, Cu Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA.;Harvard Med Sch, cBio Ctr, Dana Farber Canc Inst, Boston, MA 02115 USA.,German Canc Res Ctr, Div Appl Bioinformat, Heidelberg, Germany.;Heidelberg Univ, Fac Biosci, Heidelberg, Germany.,Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.,Harvard Medical School,German Cancer Research Centre4 aut |
| 700 | 1 | a Amin, SBu Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA.;Baylor Coll Med, Grad Program Struct & Computat Biol & Mol Biophys, Houston, TX 77030 USA.,Tech Univ Denmark, Lyngby, Denmark.;Univ Copenhagen, Copenhagen, Denmark.,German Canc Res Ctr, Div Appl Bioinformat, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT Heidelberg, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.,University of Texas MD Anderson Cancer Center4 aut |
| 700 | 1 | a Bandopadhayay, Pu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.,Broad Institute4 aut |
| 700 | 1 | a Bertl, Ju Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus, Denmark.,Aarhus University Hospital4 aut |
| 700 | 1 | a Boroevich, KAu RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Yokohama, Kanagawa, Japan.,Mem Sloan Kettering Canc Ctr, Div Computat Biol, 1275 York Ave, New York, NY 10021 USA.,Univ Zurich, Inst Mol Life Sci, Zurich, Switzerland.;Univ Zurich, Swiss Inst Bioinformat, Zurich, Switzerland.,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.,RIKEN Center for Integrative Medical Sciences,Memorial Sloan-Kettering Cancer Center,Children's University Hospital, Zurich,Broad Institute4 aut |
| 700 | 1 | a Busanovich, Ju Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.,Broad Institute4 aut |
| 700 | 1 | a Carlevaro-Fita, Ju Univ Bern, Dept BioMed Res, Bern, Switzerland.;Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland.;Univ Bern, Bern Univ Hosp, Dept Med Oncol, Bern, Switzerland.,Bern University Hospital4 aut |
| 700 | 1 | a Chakravarty, Du Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol Res, Div Canc Med, Houston, TX 77030 USA.;Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA.,University of Texas MD Anderson Cancer Center4 aut |
| 700 | 1 | a Wadelius, Claes,d 1955-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)claeswad |
| 700 | 1 | a Craft, Du Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02115 USA.,Harvard Medical School4 aut |
| 700 | 1 | a Dhingra, Pu Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA.;Weill Cornell Med, Inst Computat Biomed, New York, NY USA.,Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.,University of Mississippi Medical Center4 aut |
| 700 | 1 | a Diamanti, Klev,d 1987-u Uppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab,Uppsala University Hospital4 aut0 (Swepub:uu)kledi204 |
| 700 | 1 | a Fonseca, NA4 aut |
| 700 | 1 | a Gonzalez-Perez, Au Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.,Barcelona Institute of Science and Technology4 aut |
| 700 | 1 | a Guo, QYu Aarhus Univ, Bioinformat Res Ctr BiRC, Aarhus, Denmark.,Aarhus University4 aut |
| 700 | 1 | a Hamilton, MPu Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.,Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.,Barcelona Supercomp Ctr BSC, Barcelona, Spain.,Baylor College of Medicine4 aut |
| 700 | 1 | a Haradhvala, NJu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.,Broad Institute4 aut |
| 700 | 1 | a Hong, Cu Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA.;Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Isaev, Ku Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.;Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.,Ontario Institute for Cancer Research4 aut |
| 700 | 1 | a Johnson, TAu RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Yokohama, Kanagawa, Japan.;Tokyo Med & Dent Univ, Med Res Inst, Dept Med Sci Math, Tokyo, Japan.;Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Lab Med Sci Math, Tokyo, Japan.,RIKEN Center for Integrative Medical Sciences4 aut |
| 700 | 1 | a Juul, M4 aut |
| 700 | 1 | a Kahles, A4 aut |
| 700 | 1 | a Kahraman, A4 aut |
| 700 | 1 | a Kim, Yu Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea.,Sungkyunkwan University4 aut |
| 700 | 1 | a Komorowski, Janu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Polish Acad Sci, Inst Comp Sci, Warsaw, Poland.,Uppsala University Hospital4 aut0 (Swepub:uu)jakom133 |
| 700 | 1 | a Kumar, Ku Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.,Yale University: The Yale Colloquy for New Testament Studies4 aut |
| 700 | 1 | a Kumar, S4 aut |
| 700 | 1 | a Lee, Du Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.,Peter MacCallum Canc Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.,Yale University: The Yale Colloquy for New Testament Studies4 aut |
| 700 | 1 | a Lehmann, KVu Mem Sloan Kettering Canc Ctr, Div Computat Biol, 1275 York Ave, New York, NY 10021 USA.,Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a Li, Yu SBGD Inc, Cambridge, MA USA.;Univ Cambridge, Dept Haematol, Cambridge, England.4 aut |
| 700 | 1 | a Liu, EMu Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA.;Weill Cornell Med, Inst Computat Biomed, New York, NY USA.4 aut |
| 700 | 1 | a Lochovsky, Lu Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.4 aut |
| 700 | 1 | a Park, Ku Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea.,Sangmyung Univ, Cheonan Ind, Acad Collaborat Fdn, Cheonan, South Korea.4 aut |
| 700 | 1 | a Pich, Ou Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.4 aut |
| 700 | 1 | a Roberts, NDu Univ Cambridge, Dept Haematol, Cambridge, England.4 aut |
| 700 | 1 | a Saksena, Gu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut |
| 700 | 1 | a Schumacher, SEu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Sidiropoulos, Nu Univ Copenhagen, Rigshosp, Biotech Res & Innovat Ctr BRIC, Finsen Lab, Copenhagen, Denmark.4 aut |
| 700 | 1 | a Sieverling, Lu German Canc Res Ctr, Div Appl Bioinformat, Heidelberg, Germany.;Heidelberg Univ, Fac Biosci, Heidelberg, Germany.4 aut |
| 700 | 1 | a Sinnott-Armstrong, Nu Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA.4 aut |
| 700 | 1 | a Stewart, Cu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut |
| 700 | 1 | a Tamborero, Du Karolinska Institutet,Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.,Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany.;German Canc Res Ctr, Pediat Glioma Res Grp, Heidelberg, Germany.4 aut |
| 700 | 1 | a Tubio, JMC4 aut |
| 700 | 1 | a Umer, Husen Muhammadu Uppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)husum982 |
| 700 | 1 | a Uuskula-Reimand, Lu SickKids Res Inst, Genet & Genome Biol Program, Toronto, ON, Canada.;Tallinn Univ Technol, Dept Gene Technol, Tallinn, Estonia.4 aut |
| 700 | 1 | a Wadelius, C4 aut |
| 700 | 1 | a Wadi, Lu Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Yao, XTu New York Genome Ctr, New York, NY USA.4 aut |
| 700 | 1 | a Zhang, CZu Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Zhang, Ju Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.,Yale University: The Yale Colloquy for New Testament Studies4 aut |
| 700 | 1 | a Haber, JEu Brandeis Univ, Dept Biol, Waltham, MA 02254 USA.;Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA USA.4 aut |
| 700 | 1 | a Hobolth, Au Aarhus Univ, Bioinformat Res Ctr BiRC, Aarhus, Denmark.4 aut |
| 700 | 1 | a Imielinski, Mu New York Genome Ctr, New York, NY USA.;Weill Cornea Med, Dept Pathol & Lab Med, New York, NY USA.;Weill Cornea Med, Englander Inst Precis Med, New York, NY USA.;Weill Cornea Med, Inst Computat Biomed, New York, NY USA.;Weill Cornea Med, Meyer Canc Ctr, New York, NY USA.4 aut |
| 700 | 1 | a Kellis, Mu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA.4 aut |
| 700 | 1 | a Lawrence, MSu Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.;Univ Melbourne, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia.,Univ Tokyo, Inst Med Sci, Tokyo, Japan.4 aut |
| 700 | 1 | a von Mering, Cu Univ Zurich, Inst Mol Life Sci, Zurich, Switzerland.;Univ Zurich, Swiss Inst Bioinformat, Zurich, Switzerland.4 aut |
| 700 | 1 | a Nakagawa, Hu RIKEN Ctr Integrat Med Sci, Lab Canc Genom, Tokyo, Japan.4 aut |
| 700 | 1 | a Raphael, BJu Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA.,Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Rubin, MAu Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA.;Weill Cornell Med, Englander Inst Precis Med, New York, NY USA.;Weill Cornell Med, Meyer Canc Ctr, New York, NY USA.4 aut |
| 700 | 1 | a Sander, Cu Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA.;Harvard Med Sch, cBio Ctr, Dana Farber Canc Inst, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Stein, LDu Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.;Ontario Inst Canc Res, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Stuart, JMu Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA.4 aut |
| 700 | 1 | a Tsunoda, T4 aut |
| 700 | 1 | a Wheeler, DAu Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Johnson, Ru Univ Bern, Dept BioMed Res, Bern, Switzerland.;Univ Bern, Bern Univ Hosp, Dept Med Oncol, Bern, Switzerland.4 aut |
| 700 | 1 | a Reimand, Ju Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.;Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Gerstein, Mu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.;Yale Univ, Dept Comp Sci, POB 2158, New Haven, CT 06520 USA.,Tech Univ Denmark, Lyngby, Denmark.4 aut |
| 700 | 1 | a Khurana, Eu Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA.;Weill Cornell Med, Inst Computat Biomed, New York, NY USA.;Weill Cornell Med, Englander Inst Precis Med, New York, NY USA.;Weill Cornell Med, Meyer Canc Ctr, New York, NY USA.4 aut |
| 700 | 1 | a Campbell, PJu Wellcome Trust Sanger Inst, Hinxton, England.;Univ Cambridge, Dept Haematol, Cambridge, England.4 aut |
| 700 | 1 | a Lopez-Bigas, Nu Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.;Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain.4 aut |
| 700 | 1 | a Weischenfeldt, Ju Univ Copenhagen, Rigshosp, Biotech Res & Innovat Ctr BRIC, Finsen Lab, Copenhagen, Denmark.;European Mol Biol Lab EMBL, Genome Biol Unit, Heidelberg, Germany.4 aut |
| 700 | 1 | a Beroukhim, Ru Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Univ, Bioinformat & Integrat Genom, Cambridge, MA 02138 USA.;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Martincorena, Iu Wellcome Trust Sanger Inst, Hinxton, England.4 aut |
| 700 | 1 | a Staaf, Johanu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)onk-jst |
| 700 | 1 | a Getz, Gu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.,Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.,Univ Santiago de Compostela, Dept Zool Genet & Phys Anthropol, Santiago De Compostela, Spain.;Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Santiago De Compostela, Spain.;Univ Vigo, Biomed Res Ctr CINBIO, Vigo, Spain.,Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.;Univ Cambridge, Cambridge, England.;Univ St Andrews, Sch Med, St Andrews, Fife, Scotland.;Univ St Andrews, Sch Math & Stat, St Andrews, Fife, Scotland.,Broad Institute4 aut |
| 700 | 1 | a Bader, GDu Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Barenboim, J4 aut |
| 700 | 1 | a Brunak, Su Vancouver Prostate Ctr, Vancouver, BC, Canada.4 aut |
| 700 | 1 | a Chen, Ku Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.,Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada.4 aut |
| 700 | 1 | a Choi, JKu Korea Adv Inst Sci & Technol, Daejeon, South Korea.4 aut |
| 700 | 1 | a Deu-Pons, Ju Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.4 aut |
| 700 | 1 | a Fink, JLu Barcelona Supercomp Ctr BSC, Barcelona, Spain.;Univ Queensland, Queensland Ctr Med Genom, Inst Mol Biosci, St Lucia, Qld, Australia.4 aut |
| 700 | 1 | a Frigola, Ju Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain.4 aut |
| 700 | 1 | a Gambacorti-Passerini, Cu Univ Milano Bicocca, Monza, Italy.4 aut |
| 700 | 1 | a Garsed, DWu Peter MacCallum Canc Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Gut, IG4 aut |
| 700 | 1 | a Haan, Du Univ Calif Santa Cruz, Biomol Engn Dept, Santa Cruz, CA 95064 USA.4 aut |
| 700 | 1 | a Harmanci, AOu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Univ Texas Hlth Sci Ctr Houston, Ctr Precis Hlth, Sch Biomed Informat, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Helmy, Mu Univ Toronto, Donnelly Ctr, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Hodzic, Eu Simon Fraser Univ, Burnaby, BC, Canada.4 aut |
| 700 | 1 | a Izarzugaza, JMGu Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.4 aut |
| 700 | 1 | a Kim, JK4 aut |
| 700 | 1 | a Korbel, JOu European Mol Biol Lab EMBL, Genome Biol Unit, Heidelberg, Germany.;European Mol Biol Lab, European Bioinformat Inst EMBL EBI, Cambridge, England.4 aut |
| 700 | 1 | a Larsson, Eu Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut |
| 700 | 1 | a Li, STu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.4 aut |
| 700 | 1 | a Li, XTu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.4 aut |
| 700 | 1 | a Lou, Su Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.4 aut |
| 700 | 1 | a Marchal, Ku Univ Ghent, Dept Informat Technol, Ghent, Belgium.;Univ Ghent, Dept Plant Biotechnol & Bioinformat, Ghent, Belgium.4 aut |
| 700 | 1 | a Martinez-Fundichely, Au Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA.;Weill Cornell Med, Inst Computat Biomed, New York, NY USA.;Weill Cornell Med, Englander Inst Precis Med, New York, NY USA.4 aut |
| 700 | 1 | a McGillivray, PD4 aut |
| 700 | 1 | a Meyerson, Wu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Yale Univ, Yale Sch Med, New Haven, CT USA.,European Mol Biol Lab EMBL, Genome Biol Unit, Heidelberg, Germany.4 aut |
| 700 | 1 | a Muinos, Fu Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.;Inst Res Biomed IRB Barcelona, Barcelona, Spain.4 aut |
| 700 | 1 | a Paczkowska, M4 aut |
| 700 | 1 | a Park, K4 aut |
| 700 | 1 | a Pons, Tu Spanish Natl Canc Res Ctr, Madrid, Spain.4 aut |
| 700 | 1 | a Pulido-Tamayo, Su Univ Ghent, Dept Informat Technol, Ghent, Belgium.;Univ Ghent, Dept Plant Biotechnol & Bioinformat, Ghent, Belgium.4 aut |
| 700 | 1 | a Reyes-Salazar, Iu Inst Res Biomed IRB Barcelona, Barcelona, Spain.4 aut |
| 700 | 1 | a Reyna, MAu Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA.4 aut |
| 700 | 1 | a Rubio-Perez, Cu Univ Pompeu Fabra, Res Program Biomed Informat, Barcelona, Spain.;Inst Res Biomed IRB Barcelona, Barcelona, Spain.;Vall dHebron Inst Oncol VHIO, Barcelona, Spain.,Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.4 aut |
| 700 | 1 | a Sahinalp, SC4 aut |
| 700 | 1 | a Salichos, Lu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.4 aut |
| 700 | 1 | a Shackleton, M4 aut |
| 700 | 1 | a Shrestha, R4 aut |
| 700 | 1 | a Valencia, Au Barcelona Supercomp Ctr BSC, Barcelona, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain.4 aut |
| 700 | 1 | a Vazquez, Mu Barcelona Supercomp Ctr BSC, Barcelona, Spain.;Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Clin & Mol Med, Trondheim, Norway.4 aut |
| 700 | 1 | a Verbeke, LPCu Univ Ghent, Dept Plant Biotechnol & Bioinformat, Ghent, Belgium.;Univ Ghent, Interuniv Microelectron Ctr IMEC, Dept Informat Technol, Ghent, Belgium.4 aut |
| 700 | 1 | a Wang, JYu Washington Univ, McDonnell Genome Inst, St Louis, MO 63110 USA.;Xi An Jiao Tong Univ, Sch Comp Sci & Technol, Xian, Peoples R China.;Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Xian, Peoples R China.,Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.4 aut |
| 700 | 1 | a Warrell, Ju Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA.4 aut |
| 700 | 1 | a Waszak, SM4 aut |
| 700 | 1 | a Wu, GMu Oregon Hlth & Sci Univ, Portland, OR 97201 USA.4 aut |
| 700 | 1 | a Yu, J4 aut |
| 700 | 1 | a Zhang, XPu Xi An Jiao Tong Univ, Sch Comp Sci & Technol, Xian, Peoples R China.;Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Zhang, Yu Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT USA.;Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA.;Ohio State Univ, Comprehens Canc Ctr OSUCCC James, Columbus, OH 43210 USA.4 aut |
| 700 | 1 | a Zhao, ZM4 aut |
| 700 | 1 | a Zou, LHu Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, Chicago, IL 60611 USA.4 aut |
| 700 | 1 | a Akdemir, KC4 aut |
| 700 | 1 | a Alvarez, EG4 aut |
| 700 | 1 | a Baez-Ortega, Au Univ Cambridge, Dept Vet Med, Transmissible Canc Grp, Cambridge, England.4 aut |
| 700 | 1 | a Boutros, PCu Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada.;Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.;Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.;Univ Calif Los Angeles, Los Angeles, CA USA.4 aut |
| 700 | 1 | a Bowtell, DDL4 aut |
| 700 | 1 | a Brors, B4 aut |
| 700 | 1 | a Burns, KH4 aut |
| 700 | 1 | a Chan, K4 aut |
| 700 | 1 | a CortesCiriano, Iu Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.;Univ Cambridge, Ctr Mol Sci Informat, Dept Chem, Cambridge, England.;Harvard Med Sch, Ludwig Ctr, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Dueso-Barroso, Au Barcelona Supercomp Ctr BSC, Barcelona, Spain.4 aut |
| 700 | 1 | a Dunford, AJu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut |
| 700 | 1 | a Edwards, PAu Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.;Univ Cambridge, Cambridge, England.4 aut |
| 700 | 1 | a Estivill, Xu Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain.;Quantitat Genom Labs qGen, Barcelona, Spain.4 aut |
| 700 | 1 | a Etemadmoghadam, Du Peter MacCallum Canc Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Frenkel-Morgenstern, Mu Bar Ilan Univ, Azrieli Fac Med, Safed, Israel.4 aut |
| 700 | 1 | a Gordenin, DAu NIEHS, Genome Integr & Struct Biol Lab, Durham, NC USA.4 aut |
| 700 | 1 | a Hutter, Bu Natl Ctr Tumor Dis NCT Heidelberg, Heidelberg, Germany.;German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Heidelberg Ctr Personalized Oncol DKFZ HIPO, Heidelberg, Germany.4 aut |
| 700 | 1 | a Jones, DTWu Barcelona Supercomp Ctr BSC, Barcelona, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain.4 aut |
| 700 | 1 | a Ju, YSu Korea Adv Inst Sci & Technol, Daejeon, South Korea.;Wellcome Sanger Inst, Hinxton, England.4 aut |
| 700 | 1 | a Kazanov, MDu Skolkovo Inst Sci & Technol, Moscow, Russia.;AA Kharkevich Inst Informat Transmiss Problems, Moscow, Russia.;Dmitry Rogachev Natl Res Ctr Pediat Hematol Oncol, Moscow, Russia.4 aut |
| 700 | 1 | a Klimczak, LJu NIEHS, Integrat Bioinformat Support Grp, Durham, NC USA.4 aut |
| 700 | 1 | a Koh, Yu Seoul Natl Univ Hosp, Ctr Med Innovat, Seoul, South Korea.;Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea.4 aut |
| 700 | 1 | a Lee, EAu Harvard Med Sch, Boston, MA 02115 USA.;Boston Childrens Hosp, Div Genet & Genom, Boston, MA USA.4 aut |
| 700 | 1 | a Lee, JJKu Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.;Ludwig Ctr Harvard, Boston, MA USA.4 aut |
| 700 | 1 | a Lynch, AG4 aut |
| 700 | 1 | a Macintyre, G4 aut |
| 700 | 1 | a Markowetz, Fu Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.;Univ Cambridge, Cambridge, England.4 aut |
| 700 | 1 | a Meyerson, M4 aut |
| 700 | 1 | a Miyano, S4 aut |
| 700 | 1 | a Navarro, FCP4 aut |
| 700 | 1 | a Ossowski, Su Univ Pompeu Fabra, Barcelona, Spain.;Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain.;Univ Tubingen, Inst Med Genet & Appl Genom, Tubingen, Germany.4 aut |
| 700 | 1 | a Park, PJu Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.;Ludwig Ctr Harvard, Boston, MA USA.4 aut |
| 700 | 1 | a Pearson, JVu QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.4 aut |
| 700 | 1 | a Puiggros, M4 aut |
| 700 | 1 | a Rippe, Ku German Canc Res Ctr, Heidelberg, Germany.4 aut |
| 700 | 1 | a Roberts, SAu Washington State Univ, Ctr Reprod Biol, Sch Mol Biosci, Pullman, WA 99164 USA.4 aut |
| 700 | 1 | a RodriguezMartin, Bu Univ Santiago de Compostela, Dept Zool Genet & Phys Anthropol, Santiago De Compostela, Spain.;Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Santiago De Compostela, Spain.;Univ Vigo, Biomed Res Ctr CINBIO, Vigo, Spain.4 aut |
| 700 | 1 | a Scully, Ru Beth Israel Deaconess Med Ctr, Canc Res Inst, Boston, MA 02215 USA.4 aut |
| 700 | 1 | a Torrents, D4 aut |
| 700 | 1 | a Villasante, Iu Barcelona Supercomp Ctr BSC, Barcelona, Spain.4 aut |
| 700 | 1 | a Waddell, Nu QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.4 aut |
| 700 | 1 | a Yang, LXu Univ Chicago, Ben May Dept Canc Res, Dept Human Genet, Chicago, IL 60637 USA.4 aut |
| 700 | 1 | a Yoon, SSu Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea.4 aut |
| 700 | 1 | a Zamora, Ju Univ Santiago de Compostela, Dept Zool Genet & Phys Anthropol, Santiago De Compostela, Spain.;Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Santiago De Compostela, Spain.;Univ Vigo, Biomed Res Ctr CINBIO, Vigo, Spain.;Wellcome Sanger Inst, Hinxton, England.4 aut |
| 700 | 1 | a Chan, Calvin Wing Yiuu German Cancer Research Centre4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 cre0 (Swepub:lu)onk-abo |
| 700 | 1 | a Ringnér, Markusu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 cre0 (Swepub:lu)thep-mri |
| 710 | 2 | a Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA.;Harvard Med Sch, Boston, MA 02115 USA.b Broad Institute4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 578:7793, s. 102-+q 578:7793<102-+x 1476-4687x 0028-0836 |
| 856 | 4 | u https://www.nature.com/articles/s41586-020-1965-x.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41586-020-1965-xy Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1444508/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://dx.doi.org/10.1038/s41586-020-1965-xx freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143700177 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-020-1965-x |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412969 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/a18bfc6d-b006-4e66-af62-78b53b51633e |
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