WFRF:(Huhta H)
Sökning: WFRF:(Huhta H) > (2015-2019) > Intratumoral lactat...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03524naa a2200445 4500 | |
| 001 | oai:openarchive.ki.se:10616/45901 | |
| 003 | SwePub | |
| 008 | 240410s2017 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:135591907 | |
| 022 | a 1949-2553 | |
| 024 | 7 | a 10616/459012 hdl |
| 024 | 7 | a http://hdl.handle.net/10616/459012 URI |
| 024 | 7 | a https://doi.org/10.18632/oncotarget.152842 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1355919072 URI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kauppila, Joonas Hu Karolinska Institutet4 aut |
| 245 | 1 0 | a Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma |
| 264 | c 2017-02-11 | |
| 264 | 1 | a Stockholm :b Karolinska Institutet, Dept of Molecular Medicine and Surgery,c 2017 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in esophageal adenocarcinoma is not known. The present study was conducted to elucidate the expression of MCTs in esophageal adenocarcinoma and its precursor lesions. Results: Cytoplasmic MCT1, MCT4 and MTCO1 expression linearly increased from normal epithelium to Barrett's mucosa to dysplasia and cancer. Low cytoplasmic MCT1 expression associated with high T-class (P < 0.01), positive lymph node metastases (P < 0.05), positive distant metastases (P < 0.01) and high tumor stage (P < 0.01). High cytoplasmic MCT4 expression correlated significantly with positive distant metastases (P < 0.05). Both low MCT1 and high MCT4 histoscore predicted survival in univariate analysis (P < 0.01). MCT4 histoscore predicted survival in multivariate analysis (P = 0.043; HR 1.8 95%CI 1.0–3.1). MTCO1 expression was not correlated to clinicopathological variables or survival. Materials and Methods: MCT1, MCT4 and mitochondrial cytochrome c oxidase (MTCO1) expression were determined with immunohistochemistry in esophageal specimens from 129 patients with columnar dysplasia or adenocarcinoma. Specimens including normal esophagus (n = 88), gastric (n = 67) or intestinal metaplasia (n = 51), low-grade (n = 42), high-grade dysplasia (n = 37) and esophageal adenocarcinoma (n = 99) were evaluated. Conclusions: Major increase in markers of tumor metabolism occurs during carcinogenesis and progression of esophageal adenocarcinoma. MCT1 and MCT4 are prognostic factors in esophageal adenocarcinoma. | |
| 700 | 1 | a Huhta, Heikki4 aut |
| 700 | 1 | a Helminen, Olli4 aut |
| 700 | 1 | a Palomäki, Sami4 aut |
| 700 | 1 | a Lehenkari, Petri4 aut |
| 700 | 1 | a Saarnio, Juha4 aut |
| 700 | 1 | a Karttunen, Tuomo4 aut |
| 710 | 2 | a Karolinska Institutet |
| 710 | 2 | a Karolinska Institutet |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Oncotargetd Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgeryx 1949-2553 |
| 856 | 4 | u http://hdl.handle.net/10616/45901x primaryx Object in contextx freey FULLTEXT |
| 856 | 4 | u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15284&path%5B%5D=48856 |
| 856 | 4 8 | u http://hdl.handle.net/10616/45901 |
| 856 | 4 8 | u https://doi.org/10.18632/oncotarget.15284 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135591907 |
Hitta mer i SwePub
- Av författaren/redakt...
- Kauppila, Joonas ...
- Huhta, Heikki
- Helminen, Olli
- Palomäki, Sami
- Lehenkari, Petri
- Saarnio, Juha
- visa fler...
- Karttunen, Tuomo
- visa färre...
- Artiklar i publikationen
- Oncotarget
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
