A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

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Fältnamn	Indikatorer	Metadata
000		04201naa a2200541 4500
001		oai:lup.lub.lu.se:ea57e09d-c6a0-4ceb-824a-f31c62914a7d
003		SwePub
008		190705s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:141649060
024	7	a https://lup.lub.lu.se/record/ea57e09d-c6a0-4ceb-824a-f31c62914a7d2 URI
024	7	a https://doi.org/10.1016/j.jalz.2019.02.0042 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1416490602 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Perani, Danielau Vita-Salute San Raffaele University,San Raffaele Hospital4 aut
245	1 0	a A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
264		c 2019-06-20
264	1	b Wiley,c 2019
520		a Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653		a Amyloid
653		a Neuroinflammation
653		a PET molecular imaging
653		a Protheinopathies
653		a Radiotracers
653		a Tau
700	1	a Iaccarino, Leonardou San Raffaele Hospital,Vita-Salute San Raffaele University4 aut
700	1	a Lammertsma, Adriaan A.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Windhorst, Albert D.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Edison, Paulu Imperial College London4 aut
700	1	a Boellaard, Ronaldu Academic Medical Center of University of Amsterdam (AMC)4 aut
700	1	a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
700	1	a Nordberg, Agnetau Karolinska Institutet,Karolinska Institute4 aut
700	1	a Jacobs, Andreas H.u Johanniter Krankenhaus,University of Münster4 aut
710	2	a Vita-Salute San Raffaele Universityb San Raffaele Hospital4 org
710	2	a IMBI Project
773	0	t Alzheimer's and Dementiad : Wileyg 15:8, s. 1081-1103q 15:8<1081-1103x 1552-5260
773	0	t Alzheimer's & dementia : the journal of the Alzheimer's Associationd : Wileyg 15:8, s. 1081-1103q 15:8<1081-1103x 1552-5279
856	4	u http://dx.doi.org/10.1016/j.jalz.2019.02.004y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/ea57e09d-c6a0-4ceb-824a-f31c62914a7d
856	4 8	u https://doi.org/10.1016/j.jalz.2019.02.004
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141649060

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Av författaren/redakt...: Perani, Daniela; Iaccarino, Leona ...; Lammertsma, Adri ...; Windhorst, Alber ...; Edison, Paul; Boellaard, Ronal ...; visa fler...; Hansson, Oskar; Nordberg, Agneta; Jacobs, Andreas ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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