WFRF:(Ingelsson Erik 1975 )
Sökning: WFRF:(Ingelsson Erik 1975 ) > (2020-2024) > Proteomic profiles ...
Proteomic profiles before and during weight loss : Results from randomized trial of dietary intervention
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- Figarska, Sylwia M. (författare)
- Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Diabet Res Ctr, Stanford, CA 94305 USA.,Stanford University
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- Rigdon, Joseph (författare)
- Stanford Univ, Quantitat Sci Unit, Sch Med, Palo Alto, CA 94304 USA.,Stanford University
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- Ganna, Andrea (författare)
- Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA.,Massachusetts General Hospital,Broad Institute
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- Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA;Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Diabet Res Ctr, Stanford, CA 94305 USA. Stanford University (creator_code:org_t)
- 2020-05-13
- 2020
- Engelska.
- Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and concomitant weight loss. Further, protein biomarkers might be useful for predicting weight loss in overweight and obese individuals. We performed secondary analyses in the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) randomized intervention trial that included healthy 609 adults (18-50 years old) with BMI 28-40 kg/m(2), to evaluate associations between circulating protein biomarkers and BMI at baseline, during a weight loss diet intervention, and to assess predictive potential of baseline blood proteins on weight loss. We analyzed 263 plasma proteins at baseline and 6 months into the intervention using the Olink Proteomics CVD II, CVD III and Inflammation arrays. BMI was assessed at baseline, after 3 and 6 months of dietary intervention. At baseline, 102 of the examined inflammatory and cardiovascular biomarkers were associated with BMI (>90% with successful replication in 1,584 overweight/obese individuals from a community-based cohort study) and 130 tracked with weight loss shedding light into the pathophysiology of obesity. However, out of 263 proteins analyzed at baseline, only fibroblast growth factor 21 (FGF-21) predicted weight loss, and none helped individualize dietary assignment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- Figarska, Sylwia ...
- Rigdon, Joseph
- Ganna, Andrea
- Elmståhl, Sölve
- Lind, Lars
- Gardner, Christo ...
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- Ingelsson, Erik, ...
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