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Increases in bioact...
Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA
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- Wegmann, Mathilde Gersel (författare)
- University of Copenhagen
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- Jensen, Rikke Beck (författare)
- University of Copenhagen
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- Thankamony, Ajay (författare)
- University of Cambridge
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- Frystyk, Jan (författare)
- Aarhus University,Odense University Hospital
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- Roche, Edna (författare)
- Trinity College Dublin
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- Hoey, Hilary (författare)
- Trinity College Dublin
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- Kirk, Jeremy (författare)
- Birmingham Children's Hospital
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- Shaikh, Guftar (författare)
- Royal Hospital for Sick Children, Glasgow
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- Ivarsson, Sten A. (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology
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- Söder, Olle (författare)
- Karolinska Institutet,Karolinska Institute
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- Dunger, David B. (författare)
- University of Cambridge
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- Juul, Anders (författare)
- University of Copenhagen
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(creator_code:org_t)
- 2019-10-29
- 2020
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 105:4, s. 1291-1298
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Abstract
Ämnesord
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- Background: Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not reflect the bioactive fraction of IGF-I which reaches the IGF-I receptor at target organs. We examined endogenous IGF-bioactivity using an IGF-I kinase receptor activation (KIRA) assay that measures the ability of IGF-I to activate the IGF-IR in vitro. Aim: To compare responses of bioactive IGF and total IGF-I concentrations in short GH treated SGA children in the North European Small for Gestational Age Study (NESGAS). Material and method: In NESGAS, short SGA children (n = 101, 61 males) received GH at 67 µg/ kg/day for 1 year. IGF-I concentrations were measured by Immulite immunoassay and bioactive IGF by in-house KIRA assay. Results: Bioactive IGF increased with age in healthy pre-pubertal children (n = 94). SGA children had low-normal bioactive IGF levels at baseline (-0.12 (1.8 SD), increasing significantly after one year of high-dose GH treatment to 1.1 (1.4) SD, P < 0.01. Following high-dose GH, 68% (n = 65) of SGA children had a total IGF-I concentration >2SD (mean IGF-I 2.8 SDS), whereas only 15% (n = 15) had levels of bioactive IGF slightly above normal reference values. At baseline, bioactive IGF (SDS) was significantly correlated to height (SDS) (r = 0.29, P = 0.005), in contrast to IGF-I (SDS) (r = 0.17, P = 0.10). IGF-I (SDS) was inversely correlated to delta height (SDS) after one year of high-dose GH treatment (r = -0.22, P = 0.02). Conclusion: In contrast to total IGF-I concentrations, bioactive IGF stayed within the normal reference ranges for most SGA children during the first year of GH treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Wegmann, Mathild ...
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Jensen, Rikke Be ...
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Thankamony, Ajay
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Frystyk, Jan
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Roche, Edna
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Hoey, Hilary
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visa fler...
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Kirk, Jeremy
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Shaikh, Guftar
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Ivarsson, Sten A ...
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Söder, Olle
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Dunger, David B.
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Juul, Anders
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