Sökning: WFRF:(Johnson Toby) > Gene-centric meta-a...
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000 | 06192naa a2201177 4500 | |
001 | oai:lup.lub.lu.se:9d8b966d-69bf-40d7-a746-5f32ac5c71e7 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/44880502 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddt6262 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Yoneyama, Sachiko4 aut |
245 | 1 0 | a Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations |
264 | c 2013-12-17 | |
264 | 1 | b Oxford University Press (OUP),c 2014 |
520 | a Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to 57 412 individuals of European descent from 22 cohorts collaborating with the NHLBIs Candidate Gene Association Resource (CARe) project. The study population consisted of women and men aged 2080 years. Study participants were genotyped using the ITMAT/Broad/CARE array, which includes 50 000 cosmopolitan tagged SNPs across 2100 cardiovascular-related genes. Each trait was modeled as a function of age, study site and principal components to control for population stratification, and we conducted a fixed-effects meta-analysis. No new loci for WC were observed. For WHR analyses, three novel loci were significantly associated (P 2.4 10(6)). Previously unreported rs2811337-G near TMCC1 was associated with increased WHR ( SE, 0.048 0.008, P 7.7 10(9)) as was rs7302703-G in HOXC10 ( 0.044 0.008, P 2.9 10(7)) and rs936108-C in PEMT ( 0.035 0.007, P 1.9 10(6)). Sex-stratified analyses revealed two additional novel signals among females only, rs12076073-A in SHC1 ( 0.10 0.02, P 1.9 10(6)) and rs1037575-A in ATBDB4 ( 0.046 0.01, P 2.2 10(6)), supporting an already established sexual dimorphism of central adiposity-related genetic variants. Functional analysis using ENCODE and eQTL databases revealed that several of these loci are in regulatory regions or regions with differential expression in adipose tissue. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Guo, Yiran4 aut |
700 | 1 | a Lanktree, Matthew B.4 aut |
700 | 1 | a Barnes, Michael R.4 aut |
700 | 1 | a Elbers, Clara C.4 aut |
700 | 1 | a Karczewski, Konrad J.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Bauer, Florianne4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Beitelshees, Amber4 aut |
700 | 1 | a Berenson, Gerald S.4 aut |
700 | 1 | a Boer, Jolanda M. A.4 aut |
700 | 1 | a Burke, Gregory4 aut |
700 | 1 | a Cade, Brian4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Cooper-Dehoff, Rhonda M.4 aut |
700 | 1 | a Gaunt, Tom R.4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Gong, Yan4 aut |
700 | 1 | a Gorski, Mathias4 aut |
700 | 1 | a Heard-Costa, Nancy4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Lamonte, Michael J.4 aut |
700 | 1 | a Mcdonough, Caitrin4 aut |
700 | 1 | a Monda, Keri L.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a O'Connell, Jeffrey R.4 aut |
700 | 1 | a Ordovas, Jose4 aut |
700 | 1 | a Peter, Inga4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Shaffer, Jonathan4 aut |
700 | 1 | a Shen, Haiqinq4 aut |
700 | 1 | a Smith, Erin4 aut |
700 | 1 | a Speilotes, Liz4 aut |
700 | 1 | a Thomas, Fridtjof4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Verschuren, W. M. Monique4 aut |
700 | 1 | a Anand, Sonia S.4 aut |
700 | 1 | a Dominiczak, Anna4 aut |
700 | 1 | a Davidson, Karina W.4 aut |
700 | 1 | a Hegele, Robert A.4 aut |
700 | 1 | a Heid, Iris4 aut |
700 | 1 | a Hofker, Marten H.4 aut |
700 | 1 | a Huggins, Gordon S.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Johnson, Julie A.4 aut |
700 | 1 | a Kirkland, Susan4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Langaee, Taimour Y.4 aut |
700 | 1 | a Mccaffery, Jeanne4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Munroe, Patricia4 aut |
700 | 1 | a Murray, Sarah S.4 aut |
700 | 1 | a Papanicolaou, George4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Reilly, Muredach4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Schork, Nicholas J.4 aut |
700 | 1 | a Van der Schouw, Yvonne T.4 aut |
700 | 1 | a Shimbo, Daichi4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Yusuf, Salim4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Lange, Leslie A.4 aut |
700 | 1 | a Demerath, Ellen W.4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a North, Kari E.4 aut |
700 | 1 | a Reiner, Alex P.4 aut |
700 | 1 | a Keating, Brendan4 aut |
700 | 1 | a Taylor, Kira C.4 aut |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:9, s. 2498-2510q 23:9<2498-2510x 0964-6906x 1460-2083 |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddt626y FULLTEXT |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/23/9/2498/14142890/ddt626.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/4488050 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddt626 |
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