Sökning: WFRF:(Kahn Steven E.) > Dissecting the Shar...
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000 | 14723naa a2203637 4500 | |
001 | oai:DiVA.org:umu-197707 | |
003 | SwePub | |
008 | 220704s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:148629611 | |
009 | oai:gup.ub.gu.se/312368 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1977072 URI |
024 | 7 | a https://doi.org/10.1016/j.biopsych.2021.05.0292 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486296112 URI |
024 | 7 | a https://gup.ub.gu.se/publication/3123682 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mullins, Niamh4 aut |
245 | 1 0 | a Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors |
264 | 1 | b Elsevier,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Genetic correlation | |
653 | a Genome-wide association study | |
653 | a Pleiotropy | |
653 | a Polygenicity | |
653 | a Suicide | |
653 | a Suicide attempt | |
700 | 1 | a Kang, JooEun4 aut |
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700 | 1 | a Coleman, Jonathan R. I.4 aut |
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700 | 1 | a Lilenfeld, Lisau Karolinska Institutet4 aut |
700 | 1 | a Liu, Chih-Min4 aut |
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700 | 1 | a Scherer, Stephen W.4 aut |
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700 | 1 | a Sokolowski, Marcusu Karolinska Institutet4 aut |
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700 | 1 | a Budde, Monika4 aut |
700 | 1 | a Byrne, Enda M.4 aut |
700 | 1 | a Cahn, Wiepke4 aut |
700 | 1 | a Casas, Miguelu Karolinska Institutet4 aut |
700 | 1 | a Castelao, Enrique4 aut |
700 | 1 | a Cervilla, Jorge A.4 aut |
700 | 1 | a Chaumette, Boris4 aut |
700 | 1 | a Cichon, Sven4 aut |
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700 | 1 | a Foo, Jerome C.4 aut |
700 | 1 | a Forstner, Andreas J.4 aut |
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700 | 1 | a Fullerton, Janice M.4 aut |
700 | 1 | a Gatt, Justine M.4 aut |
700 | 1 | a Gejman, Pablo V.4 aut |
700 | 1 | a Giegling, Ina4 aut |
700 | 1 | a Grabe, Hans J.4 aut |
700 | 1 | a Green, Melissa J.4 aut |
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700 | 1 | a Ising, Marcus4 aut |
700 | 1 | a Jones, Ian4 aut |
700 | 1 | a Jones, Lisa A.4 aut |
700 | 1 | a Jonsson, Lina,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xjliny |
700 | 1 | a Kahn, René S.4 aut |
700 | 1 | a Kelsoe, John R.4 aut |
700 | 1 | a Kendler, Kenneth S.4 aut |
700 | 1 | a Kloiber, Stefan4 aut |
700 | 1 | a Koenen, Karestan C.4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Konte, Bettina4 aut |
700 | 1 | a Krebs, Marie-Odile4 aut |
700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
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700 | 1 | a Lucae, Susanne4 aut |
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710 | 2 | a Karolinska Institutetb Psykiatri4 org |
773 | 0 | t Biological Psychiatryd : Elsevierg 91:3, s. 313-327q 91:3<313-327x 0006-3223x 1873-2402 |
856 | 4 | u https://doi.org/10.1016/j.biopsych.2021.05.029y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1680203/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.biologicalpsychiatryjournal.com/article/S0006322321015705/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-197707 |
856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2021.05.029 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148629611 |
856 | 4 8 | u https://gup.ub.gu.se/publication/312368 |
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