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Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D
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- Cashman, Kevin D. (author)
- University College Cork
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- Kiely, Mairead E. (author)
- University College Cork
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- Andersen, Rikke (author)
- Technical University of Denmark
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- Gronborg, Ida M. (author)
- Technical University of Denmark
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- Madsen, Katja H. (author)
- Technical University of Denmark
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- Nissen, Janna (author)
- Technical University of Denmark
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- Tetens, Inge (author)
- University of Copenhagen,Technical University of Denmark
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- Tripkovic, Laura (author)
- University of Surrey
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- Lanham-New, Susan A. (author)
- University of Surrey
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- Toxqui, Laura (author)
- CSIC Institute of Food Science, Technology and Nutrition (ICTAN)
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- Vaquero, M. Pilar (author)
- CSIC Institute of Food Science, Technology and Nutrition (ICTAN)
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- Trautvetter, Ulrike (author)
- Friedrich Schiller University Jena
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- Jahreis, Gerhard (author)
- Friedrich Schiller University Jena
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- Mistry, Vikram V. (author)
- South Dakota State University
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- Specker, Bonny L. (author)
- South Dakota State University
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Hower, Juergen (author)
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Knoll, Anette (author)
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- Wagner, Dennis (author)
- University of Toronto
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- Vieth, Reinhold (author)
- University of Toronto,Mount Sinai Hospital of University of Toronto
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- Öhlund, Inger, 1954- (author)
- Umeå University,Umeå universitet,Pediatrik
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- Karlsland Åkeson, Pia (author)
- Lund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups
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- Brett, Neil R. (author)
- McGill University
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- Weiler, Hope A. (author)
- McGill University
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- Ritz, Christian (author)
- University of Copenhagen
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(creator_code:org_t)
- 2020-06-15
- 2021
- English.
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In: European Journal of Nutrition. - : Springer Berlin/Heidelberg. - 1436-6207 .- 1436-6215. ; 60:2, s. 939-959
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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Abstract
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- Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2–89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Vitamin D recommendations
- Dietary reference values
- Recommended dietary allowance
- Individual participant data-level meta-regression analyses
- Vitamin D-fortified foods
- Dietary reference values
- Individual participant data-level meta-regression analyses
- Recommended dietary allowance
- Vitamin D recommendations
- Vitamin D-fortified foods
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cashman, Kevin D ...
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Kiely, Mairead E ...
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Andersen, Rikke
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Gronborg, Ida M.
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Madsen, Katja H.
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Nissen, Janna
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show more...
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Tetens, Inge
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Tripkovic, Laura
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Lanham-New, Susa ...
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Toxqui, Laura
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Vaquero, M. Pila ...
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Trautvetter, Ulr ...
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Jahreis, Gerhard
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Mistry, Vikram V ...
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Specker, Bonny L ...
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Hower, Juergen
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Knoll, Anette
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Wagner, Dennis
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Vieth, Reinhold
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Öhlund, Inger, 1 ...
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Karlsland Åkeson ...
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Brett, Neil R.
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Weiler, Hope A.
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Ritz, Christian
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University
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Lund University