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Route of Vaccine Ad...
Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
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- Ols, Sebastian (author)
- Karolinska Institutet
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Yang, Lifei (author)
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Thompson, Elizabeth A. (author)
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Pushparaj, Pradeepa (author)
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Tran, Karen (author)
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- Liang, Frank (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Lin, Ang (author)
- Karolinska Institutet
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Eriksson, Bengt (author)
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- Hedestam, Gunilla B. Karlsson (author)
- Karolinska Institutet
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Wyatt, Richard T. (author)
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- Lore, Karin (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: CELL REPORTS. - : Elsevier BV. - 2211-1247. ; 30:12
- Related links:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Although intramuscular (i.m.) administration is the most commonly used route for licensed vaccines, subcutaneous (s.c.) delivery is being explored for several new vaccines under development. Here, we use rhesus macaques, physiologically relevant to humans, to identify the anatomical compartments and early immune processes engaged in the response to immunization via the two routes. Administration of fluorescently labeled HIV-1 envelope glycoprotein trimers displayed on liposomes enables visualization of targeted cells and tissues. Both s.c. and i.m. routes induce efficient immune cell infiltration, activation, and antigen uptake, functions that are tightly restricted to the skin and muscle, respectively. Antigen is also transported to different lymph nodes depending on route. However, these early differences do not translate into significant differences in the magnitude or quality of antigen-specific cellular and humoral responses over time. Thus, although some distinct immunological differences are noted, the choice of route may instead be motivated by clinical practicality.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ols, Sebastian
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Yang, Lifei
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Thompson, Elizab ...
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Pushparaj, Prade ...
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Tran, Karen
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Liang, Frank
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show more...
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Lin, Ang
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Eriksson, Bengt
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Hedestam, Gunill ...
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Wyatt, Richard T ...
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Lore, Karin
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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CELL REPORTS
- By the university
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University of Gothenburg
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Karolinska Institutet