Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Karlsson Hedestam Gunilla) > (2020-2023) > Route of Vaccine Ad...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03154naa a2200433 4500
001		oai:gup.ub.gu.se/338646
003		SwePub
008		240618s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:143297015
024	7	a https://gup.ub.gu.se/publication/3386462 URI
024	7	a https://doi.org/10.1016/j.celrep.2020.02.1112 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1432970152 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ols, Sebastianu Karolinska Institutet4 aut
245	1 0	a Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
264	1	b Elsevier BV,c 2020
520		a Although intramuscular (i.m.) administration is the most commonly used route for licensed vaccines, subcutaneous (s.c.) delivery is being explored for several new vaccines under development. Here, we use rhesus macaques, physiologically relevant to humans, to identify the anatomical compartments and early immune processes engaged in the response to immunization via the two routes. Administration of fluorescently labeled HIV-1 envelope glycoprotein trimers displayed on liposomes enables visualization of targeted cells and tissues. Both s.c. and i.m. routes induce efficient immune cell infiltration, activation, and antigen uptake, functions that are tightly restricted to the skin and muscle, respectively. Antigen is also transported to different lymph nodes depending on route. However, these early differences do not translate into significant differences in the magnitude or quality of antigen-specific cellular and humoral responses over time. Thus, although some distinct immunological differences are noted, the choice of route may instead be motivated by clinical practicality.
650	7	a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
700	1	a Yang, Lifei4 aut
700	1	a Thompson, Elizabeth A.4 aut
700	1	a Pushparaj, Pradeepa4 aut
700	1	a Tran, Karen4 aut
700	1	a Liang, Franku Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xliafr
700	1	a Lin, Angu Karolinska Institutet4 aut
700	1	a Eriksson, Bengt4 aut
700	1	a Hedestam, Gunilla B. Karlssonu Karolinska Institutet4 aut
700	1	a Wyatt, Richard T.4 aut
700	1	a Lore, Karinu Karolinska Institutet4 aut
710	2	a Karolinska Institutetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org
773	0	t CELL REPORTSd : Elsevier BVg 30:12q 30:12x 2211-1247
856	4	u http://www.cell.com/article/S2211124720302928/pdf
856	4 8	u https://gup.ub.gu.se/publication/338646
856	4 8	u https://doi.org/10.1016/j.celrep.2020.02.111
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143297015

Hitta via bibliotek

CELL REPORTS (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Ols, Sebastian; Yang, Lifei; Thompson, Elizab ...; Pushparaj, Prade ...; Tran, Karen; Liang, Frank; visa fler...; Lin, Ang; Eriksson, Bengt; Hedestam, Gunill ...; Wyatt, Richard T ...; Lore, Karin; visa färre...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Cellbiologi

Artiklar i publikationen: CELL REPORTS

Av lärosätet: Göteborgs universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se