WFRF:(Klein K.)
Sökning: WFRF:(Klein K.) > (1995-1999) > Human herpesvirus-8...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03063naa a2200337 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1938498 | |
| 003 | SwePub | |
| 008 | 240701s1999 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19384982 URI |
| 024 | 7 | a https://doi.org/10.1099/0022-1317-80-11-28892 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Szekely, Lu Karolinska Institutet4 aut |
| 245 | 1 0 | a Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies |
| 264 | 1 | b Microbiology Society,c 1999 |
| 520 | a Subnuclear distribution of the human herpesvirus-8 (HHV-8)- encoded nuclear protein LNA-1 was analysed at high resolution in body cavity (BC) lymphoma-derived cell lines, in cell hybrids between BC cells and various human and mouse cells and in freshly infected K562 and ECV cell lines. Three-dimensional reconstruction of nuclei from optical sections and quantitative analysis of the distribution of LNA-1 fluorescence in relation to chromatin showed that LNA-1 associates preferentially with the border of heterochromatin in the interphase nuclei. This was further confirmed in the following systems: in endo- and exonuclease-digested nuclei, in human–mouse (BC-1–Sp2- 0) hybrids and on chromatin spreads. LNA-1 was found to bind to mitotic chromosomes at random. Epstein–Barr virus (EBV), but not HHV-8, was rapidly lost from mouse–human hybrid cells in parallel with the loss of human chromosomes. HHV-8 could persist on the residual mouse background for more than 8 months. In early human–mouse hybrids that contain a single fused nucleus, LNA-1 preferentially associates with human chromatin. After the gradual loss of the human chromosomes, LNA-1 becomes associated with the murine pericentromeric heterochromatin. In human–human hybrids derived from the fusion of the HHV-8-carrying BCBL-1 cells and the EBV-immortalized lymphoblastoid cell line IB4, LNA-1 did not co-localize with EBNA-1, EBNA-2, EBNA-5 or EBNA-6. LNA-1 was not associated with PML containing ND10 bodies either. DNase but not RNase or detergent treatment of isolated nuclei destroys LNA-1 bodies. In advanced apoptotic cells LNA- 1 bodies remain intact but are not included in the apoptotic bodies themselves. | |
| 700 | 1 | a Kiss, C4 aut |
| 700 | 1 | a Mattsson, K4 aut |
| 700 | 1 | a Kashuba, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Pokrovskaja, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Juhasz, A4 aut |
| 700 | 1 | a Holmvall, P4 aut |
| 700 | 1 | a Klein, Gu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The Journal of general virologyd : Microbiology Societyg 8080 ( Pt 11), s. 2889-2900q 8080 ( Pt 11)<2889-2900x 0022-1317x 1465-2099 |
| 856 | 4 | u https://doi.org/10.1099/0022-1317-80-11-2889 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938498 |
| 856 | 4 8 | u https://doi.org/10.1099/0022-1317-80-11-2889 |
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