WFRF:(Kristoffersen Wiberg M)
Sökning: WFRF:(Kristoffersen Wiberg M) > Validation of Rapid...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07604naa a2201069 4500 | |
| 001 | oai:DiVA.org:kth-313560 | |
| 003 | SwePub | |
| 008 | 220613s2020 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:liu-165837 | |
| 009 | oai:prod.swepub.kib.ki.se:143818078 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3135602 URI |
| 024 | 7 | a https://doi.org/10.1002/ana.257052 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1658372 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1438180782 URI |
| 040 | a (SwePub)kthd (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ouellette, R.u Karolinska Institutet4 aut |
| 245 | 1 0 | a Validation of Rapid Magnetic Resonance Myelin Imaging in Multiple Sclerosis |
| 264 | c 2020-03-02 | |
| 264 | 1 | b Wiley,c 2020 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20220613 | |
| 520 | a Objective: Magnetic resonance imaging (MRI) is essential for multiple sclerosis diagnostics but is conventionally not specific to demyelination. Myelin imaging is often hampered by long scanning times, complex postprocessing, or lack of clinical approval. This study aimed to assess the specificity, robustness, and clinical value of Rapid Estimation of Myelin for Diagnostic Imaging, a new myelin imaging technique based on time-efficient simultaneous T1/T2 relaxometry and proton density mapping in multiple sclerosis. Methods: Rapid myelin imaging was applied using 3T MRI ex vivo in 3 multiple sclerosis brain samples and in vivo in a prospective cohort of 71 multiple sclerosis patients and 21 age/sex-matched healthy controls, with scan–rescan repeatability in a subcohort. Disability in patients was assessed by the Expanded Disability Status Scale and the Symbol Digit Modalities Test at baseline and 2-year follow-up. Results: Rapid myelin imaging correlated with myelin-related stains (proteolipid protein immunostaining and Luxol fast blue) and demonstrated good precision. Multiple sclerosis patients had, relative to controls, lower normalized whole-brain and normal-appearing white matter myelin fractions, which correlated with baseline cognitive and physical disability. Longitudinally, these myelin fractions correlated with follow-up physical disability, even with correction for baseline disability. Interpretation: Rapid Estimation of Myelin for Diagnostic Imaging provides robust myelin quantification that detects diffuse demyelination in normal-appearing tissue in multiple sclerosis, which is associated with both cognitive and clinical disability. Because the technique is fast, with automatic postprocessing and US Food and Drug Administration/CE clinical approval, it can be a clinically feasible biomarker that may be suitable to monitor myelin dynamics and evaluate treatments aiming at remyelination. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 653 | a myelin | |
| 653 | a proteolipid | |
| 653 | a adult | |
| 653 | a aged | |
| 653 | a Article | |
| 653 | a cognition | |
| 653 | a cohort analysis | |
| 653 | a controlled study | |
| 653 | a demyelination | |
| 653 | a disability | |
| 653 | a Expanded Disability Status Scale | |
| 653 | a female | |
| 653 | a follow up | |
| 653 | a human | |
| 653 | a human tissue | |
| 653 | a image processing | |
| 653 | a major clinical study | |
| 653 | a male | |
| 653 | a multiple sclerosis | |
| 653 | a nuclear magnetic resonance imaging | |
| 653 | a priority journal | |
| 653 | a prospective study | |
| 653 | a symbol digit modalities test | |
| 653 | a validation study | |
| 653 | a white matter | |
| 653 | a brain | |
| 653 | a computer assisted diagnosis | |
| 653 | a diagnostic imaging | |
| 653 | a middle aged | |
| 653 | a myelin sheath | |
| 653 | a neuroimaging | |
| 653 | a procedures | |
| 653 | a reproducibility | |
| 653 | a Humans | |
| 653 | a Image Interpretation | |
| 653 | a Computer-Assisted | |
| 653 | a Magnetic Resonance Imaging | |
| 653 | a Prospective Studies | |
| 653 | a Reproducibility of Results | |
| 700 | 1 | a Mangeat, G.u A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada4 aut |
| 700 | 1 | a Polyak, I.u Invicro, Boston, MA, United States4 aut |
| 700 | 1 | a Warntjes, Marcel, Jan Bertus,d 1973-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,SyntheticMR, Linköping, Sweden4 aut0 (Swepub:liu)marwa64 |
| 700 | 1 | a Forslin, Y.u Karolinska Institutet4 aut |
| 700 | 1 | a Bergendal, Å.u Karolinska Institutet4 aut |
| 700 | 1 | a Platten, Michaelu Karolinska Institutet,KTH,Medicinteknik och hälsosystem,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; School of Engineering Sciences in Chemistry, Biology, and Health, Royal Institute of Technology, Stockholm, Sweden4 aut0 (Swepub:kth)u19rh8fr |
| 700 | 1 | a Uppman, M.u Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden4 aut |
| 700 | 1 | a Treaba, C. A.u A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States4 aut |
| 700 | 1 | a Cohen-Adad, J.u NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada4 aut |
| 700 | 1 | a Piehl, F.u Karolinska Institutet4 aut |
| 700 | 1 | a Kristoffersen Wiberg, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Fredrikson, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Mainero, C.u A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States4 aut |
| 700 | 1 | a Granberg, T.u Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada4 org |
| 773 | 0 | t Annals of Neurologyd : Wileyg 87:5, s. 710-724q 87:5<710-724x 0364-5134x 1531-8249 |
| 856 | 4 | u https://doi.org/10.1002/ana.25705y Fulltext |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.25705 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1432636/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313560 |
| 856 | 4 8 | u https://doi.org/10.1002/ana.25705 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165837 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143818078 |
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