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Risk of subsequent ...
Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe : the PanCareSurFup study
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- Heymer, Emma J. (author)
- University of Birmingham
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- Hawkins, Michael M. (author)
- University of Birmingham
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- Winter, David L. (author)
- University of Birmingham
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- Teepen, Jop C. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Sunguc, Ceren (author)
- University of Birmingham
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- Ronckers, Cécile M. (author)
- Johannes-Gutenberg University Mainz,Princess Maxima Center for Pediatric Oncology/Hematology
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- Allodji, Rodrigue S. (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Alessi, Daniela (author)
- University of Turin
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- Sugden, Elaine (author)
- University of Birmingham
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- Belle, Fabiën N. (author)
- University of Bern,University of Lausanne
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- Bagnasco, Francesca (author)
- Gaslini Children's Hospital
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- Byrne, Julianne (author)
- Boyne Research Institute
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- Bárdi, Edit (author)
- St. Anna Children's Hospital,Kepler University Hospital Linz
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- Garwicz, Stanislaw (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups
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- Grabow, Desiree (author)
- Johannes-Gutenberg University Mainz
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- Jankovic, Momcilo (author)
- University of Milano-Bicocca
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- Kaatsch, Peter (author)
- Johannes-Gutenberg University Mainz
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- Kaiser, Melanie (author)
- Johannes-Gutenberg University Mainz
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- Michel, Gisela (author)
- University of Lucerne
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- Schindera, Christina (author)
- University Children's Hospital, Basel,University of Bern
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- Haddy, Nadia (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Journy, Neige (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Česen Mazić, Maja (author)
- University Children's Hospital, Ljubljana
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- Skinner, Roderick (author)
- University of Newcastle upon Tyne
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- Kok, Judith L. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Gunnes, Maria W. (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,Norwegian Radium Hospital
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- Wiebe, Thomas (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups
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- Sacerdote, Carlotta (author)
- University of Turin
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- Maule, Milena M. (author)
- University of Turin
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- Terenziani, Monica (author)
- Istituto Nazionale dei Tumori
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- Jakab, Zsuzsanna (author)
- Semmelweis University
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- Winther, Jeanette F. (author)
- Aarhus University Hospital,Danish Cancer Society
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- Lähteenmäki, Päivi M. (author)
- Turku University Hospital
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- Zadravec Zaletel, Lorna (author)
- Institute of Oncology, Ljubljana
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- Haupt, Riccardo (author)
- Gaslini Children's Hospital
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- Kuehni, Claudia E. (author)
- University of Bern,University Children's Hospital Bern
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- Kremer, Leontien C. (author)
- Academic Medical Center of University of Amsterdam (AMC),Princess Maxima Center for Pediatric Oncology/Hematology
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- de Vathaire, Florent (author)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Hjorth, Lars (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Reulen, Raoul C. (author)
- University of Birmingham
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: British Journal of Cancer. - 0007-0920. ; 130:6, s. 976-986
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort. Methods: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated. Results: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50. Discussion: Clinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Heymer, Emma J.
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Hawkins, Michael ...
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Winter, David L.
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Teepen, Jop C.
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Sunguc, Ceren
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Ronckers, Cécile ...
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show more...
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Allodji, Rodrigu ...
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Alessi, Daniela
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Sugden, Elaine
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Belle, Fabiën N.
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Bagnasco, France ...
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Byrne, Julianne
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Bárdi, Edit
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Garwicz, Stanisl ...
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Grabow, Desiree
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Jankovic, Momcil ...
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Kaatsch, Peter
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Kaiser, Melanie
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Michel, Gisela
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Schindera, Chris ...
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Haddy, Nadia
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Journy, Neige
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Česen Mazić, Maj ...
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Skinner, Roderic ...
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Kok, Judith L.
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Gunnes, Maria W.
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Wiebe, Thomas
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Sacerdote, Carlo ...
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Maule, Milena M.
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Terenziani, Moni ...
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Jakab, Zsuzsanna
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Winther, Jeanett ...
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Lähteenmäki, Päi ...
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Zadravec Zaletel ...
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Haupt, Riccardo
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Kuehni, Claudia ...
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Kremer, Leontien ...
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de Vathaire, Flo ...
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Hjorth, Lars
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Reulen, Raoul C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British Journal ...
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British journal ...
- By the university
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Lund University
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Karolinska Institutet