Comparison between professional sampling and self-sampling for HPV-based cervical cancer screening among postmenopausal women

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Fältnamn	Indikatorer	Metadata
000		04075naa a2200445 4500
001		oai:DiVA.org:oru-67134
003		SwePub
008		180604s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-671342 URI
024	7	a https://doi.org/10.1002/ijgo.125382 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bergengren, Lovisa,d 1971-u Örebro universitet,Institutionen för hälsovetenskaper,Department of Women’s Health4 aut0 (Swepub:oru)lvbn
245	1 0	a Comparison between professional sampling and self-sampling for HPV-based cervical cancer screening among postmenopausal women
264		c 2018-06-25
264	1	b Wiley-Blackwell Publishing Inc.c 2018
338		a print2 rdacarrier
500		a Funding Agencies:Region Örebro County Research Committee Örebro University Hospital Research Foundation BBMRI.se
520		a OBJECTIVE: To investigate whether self-sampling is as reliable as professional sampling for HPV testing and genotype detection among postmenopausal women.METHODS: In the present prospective cross-sectional study, women in Örebro County, Sweden, who had high-risk HPV (hrHPV) and normal cytology results in exit screening tests conducted in between January 1, 2012, and December 31, 2014, were invited to follow-up screenings between February 24, 2015 and May 15, 2015, that included professional sampling and self-sampling. HPV genotypes were identified by a DNA-based assay that could detect 35 HPV genotypes. Findings between the different sampling methods were compared.RESULTS: Of 143 women who participated, 119 returned a self-sample. Completely concordant results were observed in 67 of these samples when both hrHPV and low-risk HPV genotypes were analyzed. Overall, 99 (83.2%) women had the same clinically relevant finding from both sampling methods. Twenty women had discordant hrHPV results (hrHPV detected in 10 self-samples vs 10 professionally collected samples; Cohen κ 0.66, 95% confidence interval 0.53-0.80). There was no significant difference between the two sampling methods for clinically significant infections (P>0.99) or extended genotyping (P=0.827).CONCLUSION: Postmenopausal women could be offered self-sampling devices to increase screening-program coverage while maintaining test quality.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Cervical cancer
653		a HPV
653		a Postmenopausal women
653		a Professional sampling
653		a Screening
653		a Self-sample
700	1	a Kaliff, Malin,d 1985-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)mkf
700	1	a Lillsunde-Larsson, Gabriella,d 1971-u Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)geln
700	1	a Karlsson, Mats,d 1960-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)mskn
700	1	a Helenius, Gisela,d 1973-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)ghs
710	2	a Örebro universitetb Institutionen för hälsovetenskaper4 org
773	0	t International Journal of Gynecology & Obstetricsd : Wiley-Blackwell Publishing Inc.g 142:3, s. 359-364q 142:3<359-364x 0020-7292x 1879-3479
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67134
856	4 8	u https://doi.org/10.1002/ijgo.12538

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