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Differential expression of MicroRNAs in Alzheimer’s disease : a systematic review and meta-analysis

Yoon, Sojung (författare)
Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea
Kim, Sung Eun (författare)
Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea
Ko, Younhee (författare)
Hankuk University of Foreign Studies, Kyoungki-do, Republic of Korea,HankEngland Univ Foreign Studies, South Korea
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Jeong, Gwang Hun (författare)
Gyeongsang National University, Jinju, Republic of Korea,Gyeongsang Natl Univ, South Korea
Lee, Keum Hwa (författare)
Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea
Lee, Jinhee (författare)
Yonsei University Wonju College of Medicine, Wonju, Republic of Korea,Yonsei Univ, South Korea
Solmi, Marco (författare)
University of Ottawa, Ontario, ON, Canada; The Ottawa Hospital, Ontario, ON, Canada; Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada,Univ Ottawa, Canada; Ottawa Hosp, Canada; Ottawa Hosp Res Inst OHRI, Canada; Univ Ottawa, Canada
Jacob, Louis (författare)
University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France; Universitat de Barcelona, Spain,Univ Versailles St Quentin En Yvelines, France; Univ Barcelona, Spain
Smith, Lee (författare)
Anglia Ruskin University, Cambridge, UK,Anglia Ruskin Univ, England
Stickley, Andrew (författare)
Södertörns högskola,SCOHOST (Stockholm Centre for Health and Social Change),National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan,Natl Ctr Neurol & Psychiat, Japan; Sodertorn Univ, Sweden
Carvalho, Andre F. (författare)
Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada,Ctr Addict & Mental Hlth CAMH, Canada; Univ Toronto, Canada
Dragioti, Elena (författare)
Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
Kronbichler, Andreas (författare)
University of Cambridge, Cambridge, UK,Univ Cambridge, England
Koyanagi, Ai (författare)
Universitat de Barcelona, Spain; ICREA, Spain,Univ Barcelona, Spain; ICREA, Spain
Hong, Sung Hwi (författare)
Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea
Thompson, Trevor (författare)
University of Greenwich, London, UK,Univ Greenwich, England
Oh, Hans (författare)
University of Southern California, US,Univ Southern Calif, CA 90015 USA
Salazar de Pablo, Gonzalo (författare)
King’s College London, London, UK; CIBERSAM, Madrid, Spain,Kings Coll London, England; Kings Coll London, England; Univ Complutense, Spain
Radua, Joaquim (författare)
Karolinska Institutet
Shin, Jae Il (författare)
Yonsei University Wonju College of Medicine, Wonju, Republic of Korea,Yonsei Univ, South Korea
Fusar-Poli, Paolo (författare)
Kings Coll London, England; Univ Pavia, Italy; South London & Maudsley NHS Fdn Trust, England; South London & Maudsley NHS Fdn Trust, England
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 (creator_code:org_t)
2022-03-09
2022
Engelska.
Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 27, s. 2405-2413
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
https://urn.kb.se/re...
http://kipublication...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Alzheimer’s disease (AD) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. MicroRNAs (miRNAs) have attracted attention as a putative diagnostic and therapeutic target for neurodegenerative diseases. However, existing meta-analyses on AD and its association with miRNAs have produced inconsistent results. The primary objective of this study is to evaluate the magnitude and consistency of differences in miRNA levels between AD patients, mild cognitive impairment (MCI) patients and healthy controls (HC). Articles investigating miRNA levels in blood, brain tissue, or cerebrospinal fluid (CSF) of AD and MCI patients versus HC were systematically searched in PubMed/Medline from inception to February 16th, 2021. Fixed- and random-effects meta-analyses were complemented with the I2 statistic to measure the heterogeneity, assessment of publication bias, sensitivity subgroup analyses (AD severity, brain region, post-mortem versus ante-mortem specimen for CSF and type of analysis used to quantify miRNA) and functional enrichment pathway analysis. Of the 1512 miRNAs included in 61 articles, 425 meta-analyses were performed on 334 miRNAs. Fifty-six miRNAs were significantly upregulated (n = 40) or downregulated (n = 16) in AD versus HC and all five miRNAs were significantly upregulated in MCI versus HC. Functional enrichment analysis confirmed that pathways related to apoptosis, immune response and inflammation were statistically enriched with upregulated pathways in participants with AD relative to HC. This study confirms that miRNAs’ expression is altered in AD and MCI compared to HC. These findings open new diagnostic and therapeutic perspectives for this disorder.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Diagnostic markers
Molecular biology
Psychiatric disorders

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