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PRINciples of optimal antithrombotiC therapy and coagulation managEment during elective fenestrated and branched EndovaScular aortic repairS (PRINCE2SS) : An International Expert Based Delphi Consensus Study

D'Oria, Mario (författare)
Univ Hosp Trieste ASUGI, Cardiovasc Dept, Div Vasc Surg, Str Fiume 447, I-34149 Trieste, TS, Italy.
Bertoglio, Luca (författare)
Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Div Vasc Surg, Milan, Italy.
Bignamini, Angelo Antonio (författare)
Univ Milan, Sch Specialisat Hosp Pharm, Milan, Italy.
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Mani, Kevin, 1975- (författare)
Uppsala universitet,Kärlkirurgi
Kölbel, Tilo (författare)
Univ Heart & Vasc Ctr, German Aort Ctr, Dept Vasc Med, Hamburg, Germany.
Oderich, Gustavo (författare)
Univ Texas Hlth Sci Ctr Houston, Dept Cardiothorac & Vasc Surg, McGovern Med Sch, Houston, TX 77030 USA.
Chiesa, Roberto (författare)
Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Div Vasc Surg, Milan, Italy.
Lepidi, Sandro (författare)
Univ Hosp Trieste ASUGI, Cardiovasc Dept, Div Vasc Surg, Str Fiume 447, I-34149 Trieste, TS, Italy.
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Univ Hosp Trieste ASUGI, Cardiovasc Dept, Div Vasc Surg, Str Fiume 447, I-34149 Trieste, TS, Italy Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Div Vasc Surg, Milan, Italy. (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier. - 1078-5884 .- 1532-2165. ; 63:6, s. 838-850
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • ObjectiveManagement of antithrombotic therapy in patients undergoing elective fenestrated branched endovascular aortic repair (F-BEVAR) is not standardised, nor are there any recommendations from current guidelines. By designing an international expert based Delphi consensus, the study aimed to create recommendations on the pre-, intra-, and post-operative management of antithrombotic therapy in patients scheduled for elective F-BEVAR in high volume centres.MethodsEight facilitators created appropriate statements regarding the study topic that were voted on, using a four point Likert scale, by a selected panel of international experts using a three round modified Delphi consensus process. Based on the experts’ responses, only those statements reaching Grade A (full agreement ≥ 75%) or B (overall agreement ≥ 80% and full disagreement < 5%) were included in the final document. The round answers’ consistency was graded using Cohen’s k, the intraclass correlation coefficient, and, in case of double re-submission, the Fleiss k.ResultsSixty-seven experts were included in the final analysis and voted the initial 43 statements related to pre- (n = 15), intra- (n = 10), and post-operative (n = 18) management of antithrombotic drugs. At the end of the process, six statements (13%) were rejected, 20 statements (44%) received a Grade B consensus, and 18 statements (40%) reached a Grade A consensus. Most statements (27; 71%) exhibited very high or high consistency grades, and 11 (29%) a fair or poor grading. The intra-operative statements mostly concentrated on threshold for and monitoring of proper heparinisation. The pre- and post-operative statements mainly focused on indications for dual antiplatelet therapy and its management, considering the possible need for cerebrospinal fluid drainage.ConclusionBased on the elevated strength and high consistency of this international expert based Delphi consensus, most of the statements might guide current clinical management of antithrombotic therapy for elective F-BEVAR. Future studies are needed to clarify the debated issues.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Anticoagulation
Antiplatelet
Antithrombotic
Branched
Delphi
Endovascular
Fenestrated
Pararenal
Thoraco-abdominal

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