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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08668naa a2202089 4500 | |
| 001 | oai:gup.ub.gu.se/324627 | |
| 003 | SwePub | |
| 008 | 240528s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3246272 URI |
| 024 | 7 | a https://doi.org/10.1002/cncr.345822 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kang, E. Y.4 aut |
| 245 | 1 0 | a CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study |
| 264 | c 2022-12-26 | |
| 264 | 1 | b Wiley,c 2023 |
| 520 | a Background: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC. Methods: Within the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated. Results: High-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss. Conclusion: This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a CCNE1 amplification | |
| 653 | a cyclin E1 expression | |
| 653 | a high-grade serous carcinoma | |
| 653 | a ovarian cancer | |
| 653 | a prognosis | |
| 700 | 1 | a Weir, A.4 aut |
| 700 | 1 | a Meagher, N. S.4 aut |
| 700 | 1 | a Farrington, K.4 aut |
| 700 | 1 | a Nelson, G. S.4 aut |
| 700 | 1 | a Ghatage, P.4 aut |
| 700 | 1 | a Lee, C. H.4 aut |
| 700 | 1 | a Riggan, M. J.4 aut |
| 700 | 1 | a Bolithon, A.4 aut |
| 700 | 1 | a Popovic, G.4 aut |
| 700 | 1 | a Leung, B.4 aut |
| 700 | 1 | a Tang, K.4 aut |
| 700 | 1 | a Lambie, N.4 aut |
| 700 | 1 | a Millstein, J.4 aut |
| 700 | 1 | a Alsop, J.4 aut |
| 700 | 1 | a Anglesio, M. S.4 aut |
| 700 | 1 | a Ataseven, B.4 aut |
| 700 | 1 | a Barlow, E.4 aut |
| 700 | 1 | a Beckmann, M. W.4 aut |
| 700 | 1 | a Berger, J.4 aut |
| 700 | 1 | a Bisinotto, C.4 aut |
| 700 | 1 | a Bosmuller, H.4 aut |
| 700 | 1 | a Boros, J.4 aut |
| 700 | 1 | a Brand, A. H.4 aut |
| 700 | 1 | a Brooks-Wilson, A.4 aut |
| 700 | 1 | a Brucker, S. Y.4 aut |
| 700 | 1 | a Carney, M. E.4 aut |
| 700 | 1 | a Casablanca, Y.4 aut |
| 700 | 1 | a Cazorla-Jimenez, A.4 aut |
| 700 | 1 | a Cohen, P. A.4 aut |
| 700 | 1 | a Conrads, T. P.4 aut |
| 700 | 1 | a Cook, L. S.4 aut |
| 700 | 1 | a Coulson, P.4 aut |
| 700 | 1 | a Courtney-Brooks, M.4 aut |
| 700 | 1 | a Cramer, D. W.4 aut |
| 700 | 1 | a Crowe, P.4 aut |
| 700 | 1 | a Cunningham, J. M.4 aut |
| 700 | 1 | a Cybulski, C.4 aut |
| 700 | 1 | a Darcy, K. M.4 aut |
| 700 | 1 | a El-Bahrawy, M. A.4 aut |
| 700 | 1 | a Elishaev, E.4 aut |
| 700 | 1 | a Erber, R.4 aut |
| 700 | 1 | a Farrell, R.4 aut |
| 700 | 1 | a Fereday, S.4 aut |
| 700 | 1 | a Fischer, A.4 aut |
| 700 | 1 | a Garcia, M. J.4 aut |
| 700 | 1 | a Gayther, S. A.4 aut |
| 700 | 1 | a Gentry-Maharaj, A.4 aut |
| 700 | 1 | a Gilks, C. B.4 aut |
| 700 | 1 | a Grube, M.4 aut |
| 700 | 1 | a Harnett, P. R.4 aut |
| 700 | 1 | a Harrington, S. P.4 aut |
| 700 | 1 | a Harter, P.4 aut |
| 700 | 1 | a Hartmann, A.4 aut |
| 700 | 1 | a Hecht, J. L.4 aut |
| 700 | 1 | a Heikaus, S.4 aut |
| 700 | 1 | a Hein, A.4 aut |
| 700 | 1 | a Heitz, F.4 aut |
| 700 | 1 | a Hendley, J.4 aut |
| 700 | 1 | a Hernandez, B. Y.4 aut |
| 700 | 1 | a Polo, S. H.4 aut |
| 700 | 1 | a Heublein, S.4 aut |
| 700 | 1 | a Hirasawa, A.4 aut |
| 700 | 1 | a Hogdall, E.4 aut |
| 700 | 1 | a Hogdall, C. K.4 aut |
| 700 | 1 | a Horlings, H. M.4 aut |
| 700 | 1 | a Huntsman, D. G.4 aut |
| 700 | 1 | a Huzarski, T.4 aut |
| 700 | 1 | a Jewell, A.4 aut |
| 700 | 1 | a Jimenez-Linan, M.4 aut |
| 700 | 1 | a Jones, M. E.4 aut |
| 700 | 1 | a Kaufmann, S. H.4 aut |
| 700 | 1 | a Kennedy, C. J.4 aut |
| 700 | 1 | a Khabele, D.4 aut |
| 700 | 1 | a Kommoss, F. K. F.4 aut |
| 700 | 1 | a Kruitwagen, Rfpm4 aut |
| 700 | 1 | a Lambrechts, D.4 aut |
| 700 | 1 | a Le, N. D.4 aut |
| 700 | 1 | a Lener, M.4 aut |
| 700 | 1 | a Lester, J.4 aut |
| 700 | 1 | a Leung, Y.4 aut |
| 700 | 1 | a Linder, Annau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xliana |
| 700 | 1 | a Loverix, L.4 aut |
| 700 | 1 | a Lubinski, J.4 aut |
| 700 | 1 | a Madan, R.4 aut |
| 700 | 1 | a Maxwell, G. L.4 aut |
| 700 | 1 | a Modugno, F.4 aut |
| 700 | 1 | a Neuhausen, S. L.4 aut |
| 700 | 1 | a Olawaiye, A.4 aut |
| 700 | 1 | a Olbrecht, S.4 aut |
| 700 | 1 | a Orsulic, S.4 aut |
| 700 | 1 | a Palacios, J.4 aut |
| 700 | 1 | a Pearce, C. L.4 aut |
| 700 | 1 | a Pike, M. C.4 aut |
| 700 | 1 | a Quinn, C. M.4 aut |
| 700 | 1 | a Mohan, G. R.4 aut |
| 700 | 1 | a Rodriguez-Antona, C.4 aut |
| 700 | 1 | a Ruebner, M.4 aut |
| 700 | 1 | a Ryan, A.4 aut |
| 700 | 1 | a Salfinger, S. G.4 aut |
| 700 | 1 | a Sasamoto, N.4 aut |
| 700 | 1 | a Schildkraut, J. M.4 aut |
| 700 | 1 | a Schoemaker, M. J.4 aut |
| 700 | 1 | a Shah, M.4 aut |
| 700 | 1 | a Sharma, R.4 aut |
| 700 | 1 | a Shvetsov, Y. B.4 aut |
| 700 | 1 | a Singh, N.4 aut |
| 700 | 1 | a Sonke, G. S.4 aut |
| 700 | 1 | a Steele, L.4 aut |
| 700 | 1 | a Stewart, C. J. R.4 aut |
| 700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
| 700 | 1 | a Swerdlow, A. J.4 aut |
| 700 | 1 | a Talhouk, A.4 aut |
| 700 | 1 | a Tan, A.4 aut |
| 700 | 1 | a Taylor, S. E.4 aut |
| 700 | 1 | a Terry, K. L.4 aut |
| 700 | 1 | a Toloczko, A.4 aut |
| 700 | 1 | a Traficante, N.4 aut |
| 700 | 1 | a Van de Vijver, K. K.4 aut |
| 700 | 1 | a van der Aa, M. A.4 aut |
| 700 | 1 | a Van Gorp, T.4 aut |
| 700 | 1 | a Van Nieuwenhuysen, E.4 aut |
| 700 | 1 | a Van-Wagensveld, L.4 aut |
| 700 | 1 | a Vergote, I.4 aut |
| 700 | 1 | a Vierkant, R. A.4 aut |
| 700 | 1 | a Wang, C.4 aut |
| 700 | 1 | a Wilkens, L. R.4 aut |
| 700 | 1 | a Winham, S. J.4 aut |
| 700 | 1 | a Wu, A. H.4 aut |
| 700 | 1 | a Benitez, J.4 aut |
| 700 | 1 | a Berchuck, A.4 aut |
| 700 | 1 | a Dos Reis, F. J. C.4 aut |
| 700 | 1 | a DeFazio, A.4 aut |
| 700 | 1 | a Fasching, P. A.4 aut |
| 700 | 1 | a Goode, E. L.4 aut |
| 700 | 1 | a Goodman, M. T.4 aut |
| 700 | 1 | a Gronwald, J.4 aut |
| 700 | 1 | a Karlan, B. Y.4 aut |
| 700 | 1 | a Kommoss, S.4 aut |
| 700 | 1 | a Menon, U.4 aut |
| 700 | 1 | a Sinn, H. P.4 aut |
| 700 | 1 | a Staebler, A.4 aut |
| 700 | 1 | a Brenton, J. D.4 aut |
| 700 | 1 | a Bowtell, D. D.4 aut |
| 700 | 1 | a Pharoah, P. D. P.4 aut |
| 700 | 1 | a Ramus, S. J.4 aut |
| 700 | 1 | a Kobel, M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
| 773 | 0 | t Cancerd : Wileyg 129:5, s. 697-713q 129:5<697-713x 0008-543Xx 1097-0142 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/324627 |
| 856 | 4 8 | u https://doi.org/10.1002/cncr.34582 |
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- Kang, E. Y.
- Weir, A.
- Meagher, N. S.
- Farrington, K.
- Nelson, G. S.
- Ghatage, P.
- visa fler...
- Lee, C. H.
- Riggan, M. J.
- Bolithon, A.
- Popovic, G.
- Leung, B.
- Tang, K.
- Lambie, N.
- Millstein, J.
- Alsop, J.
- Anglesio, M. S.
- Ataseven, B.
- Barlow, E.
- Beckmann, M. W.
- Berger, J.
- Bisinotto, C.
- Bosmuller, H.
- Boros, J.
- Brand, A. H.
- Brooks-Wilson, A ...
- Brucker, S. Y.
- Carney, M. E.
- Casablanca, Y.
- Cazorla-Jimenez, ...
- Cohen, P. A.
- Conrads, T. P.
- Cook, L. S.
- Coulson, P.
- Courtney-Brooks, ...
- Cramer, D. W.
- Crowe, P.
- Cunningham, J. M ...
- Cybulski, C.
- Darcy, K. M.
- El-Bahrawy, M. A ...
- Elishaev, E.
- Erber, R.
- Farrell, R.
- Fereday, S.
- Fischer, A.
- Garcia, M. J.
- Gayther, S. A.
- Gentry-Maharaj, ...
- Gilks, C. B.
- Grube, M.
- Harnett, P. R.
- Harrington, S. P ...
- Harter, P.
- Hartmann, A.
- Hecht, J. L.
- Heikaus, S.
- Hein, A.
- Heitz, F.
- Hendley, J.
- Hernandez, B. Y.
- Polo, S. H.
- Heublein, S.
- Hirasawa, A.
- Hogdall, E.
- Hogdall, C. K.
- Horlings, H. M.
- Huntsman, D. G.
- Huzarski, T.
- Jewell, A.
- Jimenez-Linan, M ...
- Jones, M. E.
- Kaufmann, S. H.
- Kennedy, C. J.
- Khabele, D.
- Kommoss, F. K. F ...
- Kruitwagen, Rfpm
- Lambrechts, D.
- Le, N. D.
- Lener, M.
- Lester, J.
- Leung, Y.
- Linder, Anna
- Loverix, L.
- Lubinski, J.
- Madan, R.
- Maxwell, G. L.
- Modugno, F.
- Neuhausen, S. L.
- Olawaiye, A.
- Olbrecht, S.
- Orsulic, S.
- Palacios, J.
- Pearce, C. L.
- Pike, M. C.
- Quinn, C. M.
- Mohan, G. R.
- Rodriguez-Antona ...
- Ruebner, M.
- Ryan, A.
- Salfinger, S. G.
- Sasamoto, N.
- Schildkraut, J. ...
- Schoemaker, M. J ...
- Shah, M.
- Sharma, R.
- Shvetsov, Y. B.
- Singh, N.
- Sonke, G. S.
- Steele, L.
- Stewart, C. J. R ...
- Sundfeldt, Karin ...
- Swerdlow, A. J.
- Talhouk, A.
- Tan, A.
- Taylor, S. E.
- Terry, K. L.
- Toloczko, A.
- Traficante, N.
- Van de Vijver, K ...
- van der Aa, M. A ...
- Van Gorp, T.
- Van Nieuwenhuyse ...
- Van-Wagensveld, ...
- Vergote, I.
- Vierkant, R. A.
- Wang, C.
- Wilkens, L. R.
- Winham, S. J.
- Wu, A. H.
- Benitez, J.
- Berchuck, A.
- Dos Reis, F. J. ...
- DeFazio, A.
- Fasching, P. A.
- Goode, E. L.
- Goodman, M. T.
- Gronwald, J.
- Karlan, B. Y.
- Kommoss, S.
- Menon, U.
- Sinn, H. P.
- Staebler, A.
- Brenton, J. D.
- Bowtell, D. D.
- Pharoah, P. D. P ...
- Ramus, S. J.
- Kobel, M.
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