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Identification of N...
Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in over 140,000 European Descendants
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- Wu, Lang (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Univ Hawaii Manoa, Canc Epidemiol Div, Populat Sci Pacific Program, Univ Hawaii Canc Ctr, Honolulu, HI 96822 USA
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- Wang, Jifeng (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA;Fifth Peoples Hosp Shanghai, Dept Urol, Shanghai, Peoples R China
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- Cai, Qiuyin (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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show more...
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- Cavazos, Taylor B. (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Emami, Nima C. (author)
- Univ Calif San Francisco, Program Biol & Med Informat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
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- Long, Jirong (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Shu, Xiao-Ou (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Lu, Yingchang (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Guo, Xingyi (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Bauer, Joshua A. (author)
- Vanderbilt Univ, Dept Biochem, Sch Med, Nashville, TN 37203 USA;Vanderbilt Univ, Sch Med, Vanderbilt Inst Chem Biol, High Throughput Screening Facil, Nashville, TN 37203 USA
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- Pasaniuc, Bogdan (author)
- Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
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- Penney, Kathryn L. (author)
- Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard Med Sch, Channing Div Network Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA
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- Freedman, Matthew L. (author)
- Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA;Broad Inst, Cambridge, MA USA
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- Kote-Jarai, Zsofia (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England;Royal Marsden NHS Fdn Trust, London, England;Inst Canc Res, London, England
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- Witte, John S. (author)
- Univ Calif San Francisco, Program Biol & Med Informat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
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- Haiman, Christopher A. (author)
- Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
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- Eeles, Rosalind A. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England;Royal Marsden NHS Fdn Trust, London, England;Inst Canc Res, London, England
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- Zheng, Wei (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37203 USA
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- Benlloch, Sara (author)
- Inst Canc Res, London, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England
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- Henderson, Brian E. (author)
- Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
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- Conti, David, V (author)
- Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
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- Schumacher, Fredrick R. (author)
- Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA;Univ Hosp Cleveland, Seidman Canc Ctr, Cleveland, OH 44106 USA
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- Easton, Douglas (author)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England
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- Al Olama, Ali Amin (author)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England;Univ Cambridge, Dept Clin Neurosci, Cambridge, England
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- Muir, Kenneth (author)
- Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester, Lancs, England;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England
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- Berndt, Sonja, I (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Chanock, Stephen (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Albanes, Demetrius (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Weinstein, Stephanie (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Koutros, Stella (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Wildund, Fredrik (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Gronberg, Henrik (author)
- Karolinska Institutet
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- Gapstur, Susan M. (author)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
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- Stevens, Victoria L. (author)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
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- Tangen, Catherine M. (author)
- Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA
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- Batra, Jyotsna (author)
- Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia
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- Clements, Judith (author)
- Australian Prostate Canc Res Ctr BioResource APCB, Translat Res Inst, Brisbane, Qld, Australia
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- Pashayan, Nora (author)
- UCL, Dept Appl Hlth Res, London, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Lab, Cambridge, England
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- Schleutker, Johanna (author)
- Univ Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland;Turku Univ Hosp, Tyks Microbiol & Genet, Dept Med Genet, Turku, Finland
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Div Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden
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- West, Catharine (author)
- Univ Manchester, Christie Hosp NHS Fdn Trust, Manchester Acad Hlth Sci,Div Canc Sci, Radiotherapy Related Res,Manchester NIHR Biomed R, Manchester, Lancs, England
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- Mucci, Lorelei (author)
- Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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- Cancel-Tassin, Geraldine (author)
- Tenon Hosp, CeRePP, Paris, France;UPMC Sorbonne Univ, GRC ONCOTYPE URO 5, Tenon Hosp, 4 Rue Chine, Paris, France
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- Sorensen, Karina Dalsgaard (author)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark;Aarhus Univ, Dept Clin Med, Aarhus, Denmark
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- Grindedal, Eli Marie (author)
- Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
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- Neal, David E. (author)
- Univ Cambridge, Dept Oncol, Addenbrookes Hosp, Cambridge, England;Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge, England
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- Hamdy, Freddie C. (author)
- Univ Oxford, Nuffield Dept Surg Sci, Oxford, England;Univ Oxford, Fac Med Sci, John Radcliffe Hosp, Oxford, England
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- Donovan, Jenny L. (author)
- Univ Bristol, Sch Social & Community Med, Bristol, Avon, England
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- Travis, Ruth C. (author)
- Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England
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- Hamilton, Robert J. (author)
- Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada
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- Rosenstein, Bany S. (author)
- Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
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- Lu, Yong-Jie (author)
- Queen Mary Univ London, Ctr Mol Oncol, Barts Canc Inst, John Vane Sci Ctr, London, England
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- Giles, Graham G. (author)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
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- Kibel, Adam S. (author)
- Brigham & Womens Hosp, Div Urol Surg, 75 Francis St, Boston, MA 02115 USA
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- Vega, Ana (author)
- IDIS, Fdn Publ Galega Med Xenom SERGAS, Grp Med Xenom, CIBERER, Santiago De Compostela, Spain
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- Kogevinas, Manolis (author)
- Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain;CIBERESP, Madrid, Spain;IMIM Hosp del Mar Res Inst, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain
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- Park, Jong Y. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
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- Stanford, Janet L. (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Newcomb, Lisa F. (author)
- Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA;Univ Washington, Dept Urol, Seattle, WA 98195 USA
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- Cybulski, Cezary (author)
- Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
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- Nordestgaard, Borge G. (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark;Copenhagen Univ Hosp, Dept Clin Biochem, Herlev & Gentofte Hosp, Herlev, Denmark
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- Brenner, Hermann (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTZ, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany
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- Maier, Christian (author)
- Univ Hosp Ulm, Inst Human Genet, Ulm, Germany
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- Kim, Jeri (author)
- Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
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- John, Esther M. (author)
- Stanford Univ, Dept Med Oncol, Sch Med, Stanford, CA USA;Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA
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- Teixeira, Manuel R. (author)
- Portuguese Oncol Inst Porto, Dept Genet, Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal
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- Neuhausen, Susan L. (author)
- City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
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- De Ruyck, Kim (author)
- Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium
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- Razack, Azad (author)
- Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia
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- Gamulin, Marija (author)
- Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Hamburg, Germany
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- Kaneva, Radka (author)
- Med Univ, Mol Med Ctr, Dept Med Chem & Biochem, Sofia, Bulgaria
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- Usmani, Nawaid (author)
- Univ Alberta, Dept Oncol, Cross Canc Inst, Edmonton, AB, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada
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- Claessens, Frank (author)
- Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Leuven, Belgium
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- Townsend, Paul A. (author)
- Univ Manchester, Manchester Canc Res Ctr, Hlth Innovat Manchester,Fac Biol Med & Hlth,Div C, Manchester Acad Hlth Sci Ctr,NIHR Manchester Biom, Manchester, Lancs, England
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- Gago Dominguez, Manuela (author)
- Complejo Hosp Univ Santiago, Genom Med Grp, Serv Galego Saude,Galician Fdn Genom Med,SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
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- Roobol, Monique J. (author)
- Erasmus MC, Dept Urol, Rotterdam, Netherlands
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- Menegaux, Florence (author)
- Univ Paris Saclay, Univ Paris Sud, Canc & Environm Grp, Ctr Res Epidemiol & Populat Hlth CESP,INSERM, Villejuif, France
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- Khaw, Kay-Tee (author)
- Univ Cambridge, Clin Gerontol Unit, Cambridge, England
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- Cannon-Albright, Lisa (author)
- Univ Utah, Sch Med, Dept Med, Div Genet Epidemiol, Salt Lake City, UT USA;Vet Affairs Med Ctr, George E Wahlen Dept, Salt Lake City, UT 84148 USA
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- Thibodeau, Stephen N. (author)
- Univ Surrey, Guildford, Surrey, England;Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
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- Hunter, David J. (author)
- Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Dept Epidemiol, Boston, MA USA
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- Blot, William J. (author)
- Vanderbilt Univ, Med Ctr, Div Epidemiol, Dept Med, Nashville, TN 37203 USA;Int Epidemiol Inst, Rockville, MD USA
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- Riboli, Elio (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England
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(creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2019
- 2019
- English.
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In: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 79:13, s. 3192-3204
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a transcriptome-wide association study in 79,194 cases and 61,112 controls of European ancestry. Using data from the Genotype-Tissue Expression Project, we established genetic models to predict gene expression across the transcriptome for both prostate models and cross-tissue models and evaluated model performance using two independent datasets. We identified significant associations for 137 genes at P < 2.61 x 10(-6), a Bonferroni-corrected threshold, including nine genes that remained significant at P < 2.61 x 10(-6) after adjusting for all known prostate cancer risk variants in nearby regions. Of the 128 remaining associated genes, 94 have not yet been reported as potential target genes at known loci. We silenced 14 genes and many showed a consistent effect on viability and colony-forming efficiency in three cell lines. Our study provides substantial new information to advance our understanding of prostate cancer genetics and biology. Significance: This study identifies novel prostate cancer genetic loci and possible causal genes, advancing our understanding of the molecular mechanisms that drive prostate cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
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- By the author/editor
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Wu, Lang
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Wang, Jifeng
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Cai, Qiuyin
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Cavazos, Taylor ...
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Emami, Nima C.
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Long, Jirong
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Shu, Xiao-Ou
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Lu, Yingchang
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Guo, Xingyi
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Bauer, Joshua A.
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Pasaniuc, Bogdan
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Penney, Kathryn ...
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Freedman, Matthe ...
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Kote-Jarai, Zsof ...
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Witte, John S.
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Haiman, Christop ...
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Eeles, Rosalind ...
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Zheng, Wei
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Benlloch, Sara
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Henderson, Brian ...
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Conti, David, V
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Schumacher, Fred ...
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Easton, Douglas
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Al Olama, Ali Am ...
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Muir, Kenneth
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Berndt, Sonja, I
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Chanock, Stephen
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Albanes, Demetri ...
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Weinstein, Steph ...
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Koutros, Stella
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Wildund, Fredrik
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Gronberg, Henrik
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Gapstur, Susan M ...
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Stevens, Victori ...
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Tangen, Catherin ...
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Batra, Jyotsna
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Clements, Judith
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Pashayan, Nora
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Schleutker, Joha ...
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Wolk, Alicja
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West, Catharine
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Mucci, Lorelei
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Cancel-Tassin, G ...
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Sorensen, Karina ...
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Grindedal, Eli M ...
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Neal, David E.
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Hamdy, Freddie C ...
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Donovan, Jenny L ...
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Travis, Ruth C.
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Hamilton, Robert ...
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Rosenstein, Bany ...
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Lu, Yong-Jie
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Giles, Graham G.
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Kibel, Adam S.
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Vega, Ana
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Kogevinas, Manol ...
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Park, Jong Y.
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Stanford, Janet ...
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Newcomb, Lisa F.
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Cybulski, Cezary
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Nordestgaard, Bo ...
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Brenner, Hermann
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Maier, Christian
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Kim, Jeri
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John, Esther M.
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Teixeira, Manuel ...
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Neuhausen, Susan ...
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De Ruyck, Kim
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Razack, Azad
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Gamulin, Marija
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Kaneva, Radka
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Usmani, Nawaid
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Claessens, Frank
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Townsend, Paul A ...
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Gago Dominguez, ...
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Roobol, Monique ...
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Menegaux, Floren ...
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Khaw, Kay-Tee
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Cannon-Albright, ...
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Thibodeau, Steph ...
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Hunter, David J.
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Blot, William J.
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Riboli, Elio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cancer Research
- By the university
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Uppsala University
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Karolinska Institutet