Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?

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Fältnamn	Indikatorer	Metadata
000		03226naa a2200565 4500
001		oai:DiVA.org:uu-10919
003		SwePub
008		070504s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:116020437
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109192 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1160204372 URI
024	7	a https://doi.org/10.1177/1945892405019006052 DOI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Barck, Charlotte4 aut
245	1 0	a Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?
264	1	b SAGE Publications,c 2005
338		a print2 rdacarrier
520		a BACKGROUND: Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2 effect occurs also in the upper airways. METHODS: Sixteen allergic subjects with rhinitis and mild asthma were exposed at rest to either purified air or 500 microg/m3 NO2 for 30 minutes, followed 4 hours later by a nasal allergen challenge. Nasal lavage was performed before air/NO2 exposure, before allergen challenge, and 1, 4 and 18 hours after allergen challenge. Symptoms were recorded. RESULTS: The percentage of eosinophils and neutrophils, eosinophil cationic protein, and myeloperoxidase were similar after exposure to air + allergen and to NO2 + allergen. We noticed a tendency to increased sneezing the day after exposure to NO2 + allergen. CONCLUSION: The priming effect of an ambient brief NO2 exposure on subsequent allergic response was not noticeable in activation of inflammatory cells and mediators in the upper airways.
653		a Adult
653		a Allergens
653		a Asthma/*immunology
653		a Eosinophil Cationic Protein/*analysis
653		a Eosinophils/cytology
653		a Female
653		a Humans
653		a Leukocyte Count
653		a Male
653		a Middle Aged
653		a Nasal Lavage Fluid/chemistry/cytology
653		a Nasal Provocation Tests
653		a Neutrophils/cytology
653		a Nitrogen Dioxide/*pharmacology
653		a Peroxidase/*analysis
653		a Pollen
653		a Rhinitis; Allergic; Seasonal/*immunology
653		a MEDICINE
653		a MEDICIN
700	1	a Lundahl, Joachimu Karolinska Institutet4 aut
700	1	a Holmström, Matsu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Ear-Nose-Throat4 aut0 (Swepub:uu)mahol676
700	1	a Bylin, Gunnar4 aut
710	2	a Karolinska Institutetb Institutionen för kirurgiska vetenskaper4 org
773	0	t American Journal of Rhinologyd : SAGE Publicationsg 19:6, s. 560-566q 19:6<560-566x 1050-6586x 1539-6290
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16402641&dopt=Citation
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10919
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:116020437
856	4 8	u https://doi.org/10.1177/194589240501900605

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Av författaren/redakt...: Barck, Charlotte; Lundahl, Joachim; Holmström, Mats; Bylin, Gunnar

Artiklar i publikationen: American Journal ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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