Sökning: WFRF:(Lundgren Jakob) > Profiling of the pl...
Fältnamn | Indikatorer | Metadata |
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000 | 05930naa a2200565 4500 | |
001 | oai:prod.swepub.kib.ki.se:142842841 | |
003 | SwePub | |
008 | 240701s2019 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5939f427-03cb-4d11-8476-76b515273cd2 | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428428412 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-13306-y2 DOI |
024 | 7 | a https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd22 URI |
040 | a (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Egerstedt, Annau Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)an6325ka |
245 | 1 0 | a Profiling of the plasma proteome across different stages of human heart failure |
264 | c 2019-12-20 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Berntsson, Johnu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jhb |
700 | 1 | a Smith, Maya Landenhedu Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-myl |
700 | 1 | a Gidlöf, Olofu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-ogf |
700 | 1 | a Nilsson, Ru Karolinska Institute,Karolinska University Hospital4 aut |
700 | 1 | a Benson, Mu Beth Israel Deaconess Medical Center,Harvard University4 aut |
700 | 1 | a Wells, QSu Vanderbilt University,Beth Israel Deaconess Medical Center,Harvard University4 aut |
700 | 1 | a Celik, Selviu Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-slc |
700 | 1 | a Lejonberg, Carlu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)ca2605le |
700 | 1 | a Farrell, Lu Harvard University,Beth Israel Deaconess Medical Center4 aut |
700 | 1 | a Sinha, S4 aut |
700 | 1 | a Shen, DXu Beth Israel Deaconess Medical Center,Harvard University4 aut |
700 | 1 | a Lundgren, Jakobu Lund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-jle |
700 | 1 | a Rådegran, Göranu Lund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-grd |
700 | 1 | a Ngo, Du Beth Israel Deaconess Medical Center,Harvard University4 aut |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Yang, Qu Boston University4 aut |
700 | 1 | a Wang, TJu Vanderbilt University4 aut |
700 | 1 | a Gerszten, REu Harvard University,Beth Israel Deaconess Medical Center,Broad Institute4 aut |
700 | 1 | a Smith, J. Gustavu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Broad Institute,Skåne University Hospital4 aut0 (Swepub:lu)med-gvs |
710 | 2 | a Molecular Epidemiology and Cardiologyb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 5830-q 10:1<5830-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-019-13306-y.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41467-019-13306-yx freey FULLTEXT |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142842841 |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-13306-y |
856 | 4 8 | u https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd2 |
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