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Sökning: WFRF:(Lundgren Jakob) > Profiling of the pl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005930naa a2200565 4500
001oai:prod.swepub.kib.ki.se:142842841
003SwePub
008240701s2019 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:5939f427-03cb-4d11-8476-76b515273cd2
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428428412 URI
024a https://doi.org/10.1038/s41467-019-13306-y2 DOI
024a https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd22 URI
040 a (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Egerstedt, Annau Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)an6325ka
2451 0a Profiling of the plasma proteome across different stages of human heart failure
264 c 2019-12-20
264 1b Springer Science and Business Media LLC,c 2019
520 a Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700a Berntsson, Johnu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jhb
700a Smith, Maya Landenhedu Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-myl
700a Gidlöf, Olofu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-ogf
700a Nilsson, Ru Karolinska Institute,Karolinska University Hospital4 aut
700a Benson, Mu Beth Israel Deaconess Medical Center,Harvard University4 aut
700a Wells, QSu Vanderbilt University,Beth Israel Deaconess Medical Center,Harvard University4 aut
700a Celik, Selviu Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-slc
700a Lejonberg, Carlu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)ca2605le
700a Farrell, Lu Harvard University,Beth Israel Deaconess Medical Center4 aut
700a Sinha, S4 aut
700a Shen, DXu Beth Israel Deaconess Medical Center,Harvard University4 aut
700a Lundgren, Jakobu Lund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-jle
700a Rådegran, Göranu Lund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-grd
700a Ngo, Du Beth Israel Deaconess Medical Center,Harvard University4 aut
700a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
700a Yang, Qu Boston University4 aut
700a Wang, TJu Vanderbilt University4 aut
700a Gerszten, REu Harvard University,Beth Israel Deaconess Medical Center,Broad Institute4 aut
700a Smith, J. Gustavu Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Broad Institute,Skåne University Hospital4 aut0 (Swepub:lu)med-gvs
710a Molecular Epidemiology and Cardiologyb Forskargrupper vid Lunds universitet4 org
773t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 5830-q 10:1<5830-x 2041-1723
856u https://www.nature.com/articles/s41467-019-13306-y.pdf
856u http://dx.doi.org/10.1038/s41467-019-13306-yx freey FULLTEXT
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142842841
8564 8u https://doi.org/10.1038/s41467-019-13306-y
8564 8u https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd2

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