Sökning: WFRF:(Lyon Christopher) > Genome-wide associa...
Fältnamn | Indikatorer | Metadata |
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000 | 08887naa a2201141 4500 | |
001 | oai:lup.lub.lu.se:4c3f4bd1-ec53-4b36-a53c-564bc07ba43c | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6639522 URI |
024 | 7 | a https://doi.org/10.1126/science.11423582 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Saxena, Richa4 aut |
245 | 1 0 | a Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2007 |
520 | a New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Burtt, Noel P.4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Chen, Hong4 aut |
700 | 1 | a Roix, Jeffrey J.4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
700 | 1 | a Hirschhorn, Joel N.4 aut |
700 | 1 | a Daly, Mark J.4 aut |
700 | 1 | a Hughes, Thomas E.4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Florez, Jose C.4 aut |
700 | 1 | a Meyer, Joanne4 aut |
700 | 1 | a Ardlie, Kristin4 aut |
700 | 1 | a Bengtsson Boström, Kristinau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)smi-kb0 |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Lettre, Guillaume4 aut |
700 | 1 | a Lindblad, Ulfu Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups4 aut0 (Swepub:lu)smi-uli |
700 | 1 | a Lyon, Helen N.4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Newton-Cheh, Christopher4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Råstam, Lennartu Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups4 aut0 (Swepub:lu)smi-lra |
700 | 1 | a Speliotes, Elizabeth K.4 aut |
700 | 1 | a Taskinen, Marja-Riitta4 aut |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a Guiducci, Candace4 aut |
700 | 1 | a Berglund, Annau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-abe |
700 | 1 | a Carlson, Joyceu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-jca |
700 | 1 | a Gianniny, Lauren4 aut |
700 | 1 | a Hackett, Rachel4 aut |
700 | 1 | a Hall, Liselotte4 aut |
700 | 1 | a Holmkvist, Johanu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-jho |
700 | 1 | a Laurila, Esau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-ela |
700 | 1 | a Sjögren, Marketau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-msj |
700 | 1 | a Sterner, Maria4 aut |
700 | 1 | a Surti, Aarti4 aut |
700 | 1 | a Svensson, Margaretau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-msv |
700 | 1 | a Svensson, Malinu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mab |
700 | 1 | a Tewhey, Ryan4 aut |
700 | 1 | a Blumenstiel, Brendan4 aut |
700 | 1 | a Parkin, Melissa4 aut |
700 | 1 | a DeFelice, Matthew4 aut |
700 | 1 | a Barry, Rachel4 aut |
700 | 1 | a Brodeur, Wendy4 aut |
700 | 1 | a Camarata, Jody4 aut |
700 | 1 | a Chia, Nancy4 aut |
700 | 1 | a Fava, Mary4 aut |
700 | 1 | a Gibbons, John4 aut |
700 | 1 | a Handsaker, Bob4 aut |
700 | 1 | a Healy, Claire4 aut |
700 | 1 | a Nguyen, Kieu4 aut |
700 | 1 | a Gates, Casey4 aut |
700 | 1 | a Sougnez, Carrie4 aut |
700 | 1 | a Gage, Diane4 aut |
700 | 1 | a Nizzari, Marcia4 aut |
700 | 1 | a Gabriel, Stacey B.4 aut |
700 | 1 | a Chirn, Gung-Wei4 aut |
700 | 1 | a Ma, Qicheng4 aut |
700 | 1 | a Parikh, Hemangu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-hpa |
700 | 1 | a Richardson, Delwood4 aut |
700 | 1 | a Ricke, Darrell4 aut |
700 | 1 | a Purcell, Shaun4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Scienced : American Association for the Advancement of Science (AAAS)g 316:5829, s. 1331-1336q 316:5829<1331-1336x 1095-9203x 0036-8075 |
856 | 4 | u http://dx.doi.org/10.1126/science.1142358y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/663952 |
856 | 4 8 | u https://doi.org/10.1126/science.1142358 |
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