Sökning: WFRF:(Monoranu Camelia) >
Targeting Coagulati...
Targeting Coagulation Factor XII as a Novel Therapeutic Option in Brain Trauma
-
- Hopp, Sarah (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.;Univ Hosp Wurzburg, Dept Neurosurg, D-97080 Wurzburg, Germany.
-
- Albert-Weissenberger, Christiane (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.;Univ Hosp Wurzburg, Dept Neurosurg, D-97080 Wurzburg, Germany.
-
- Mencl, Stine (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.
-
visa fler...
-
- Bieber, Michael (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.;Univ Hosp Wurzburg, Comprehens Heart Failure Ctr DZHI, D-97080 Wurzburg, Germany.
-
- Schuhmann, Michael K. (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.
-
- Stetter, Christian (författare)
- Univ Hosp Wurzburg, Dept Neurosurg, D-97080 Wurzburg, Germany.
-
- Nieswandt, Bernhard (författare)
- Univ Wurzburg, Rudolf Virchow Ctr, German Res Soc, Res Ctr Expt Biomed, D-97070 Wurzburg, Germany.
-
- Schmidt, Peter M. (författare)
- CSL Ltd, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic, Australia.
-
- Monoranu, Camelia-Maria (författare)
- Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Dept Neuropathol, D-97070 Wurzburg, Germany.
-
- Alafuzoff, Irina (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Marklund, Niklas (författare)
- Uppsala universitet,Neurokirurgi
-
- Nolte, Marc W. (författare)
- CSL Behring, Marburg, Germany.
-
- Siren, Anna-Leena (författare)
- Univ Hosp Wurzburg, Dept Neurosurg, D-97080 Wurzburg, Germany.
-
- Kleinschnitz, Christoph (författare)
- Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany.
-
visa färre...
-
Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany;Univ Hosp Wurzburg, Dept Neurosurg, D-97080 Wurzburg, Germany. Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany. (creator_code:org_t)
- 2016-04-28
- 2016
- Engelska.
-
Ingår i: Annals of Neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 79:6, s. 970-982
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Traumatic brain injury is a major global public health problem for which specific therapeutic interventions are lacking. There is, therefore, a pressing need to identify innovative pathomechanism-based effective therapies for this condition. Thrombus formation in the cerebral microcirculation has been proposed to contribute to secondary brain damage by causing pericontusional ischemia, but previous studies have failed to harness this finding for therapeutic use. The aim of this study was to obtain preclinical evidence supporting the hypothesis that targeting factor XII prevents thrombus formation and has a beneficial effect on outcome after traumatic brain injury.Methods: We investigated the impact of genetic deficiency of factor XII and acute inhibition of activated factor XII with a single bolus injection of recombinant human albumin-fused infestin-4 (rHA-Infestin-4) on trauma-induced microvascular thrombus formation and the subsequent outcome in 2 mouse models of traumatic brain injury.Results: Our study showed that both genetic deficiency of factor XII and an inhibition of activated factor XII in mice minimize trauma-induced microvascular thrombus formation and improve outcome, as reflected by better motor function, reduced brain lesion volume, and diminished neurodegeneration. Administration of human factor XII in factor XII-deficient mice fully restored injury-induced microvascular thrombus formation and brain damage.Interpretation: The robust protective effect of rHA-Infestin-4 points to a novel treatment option that can decrease ischemic injury after traumatic brain injury without increasing bleeding tendencies.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hopp, Sarah
-
Albert-Weissenbe ...
-
Mencl, Stine
-
Bieber, Michael
-
Schuhmann, Micha ...
-
Stetter, Christi ...
-
visa fler...
-
Nieswandt, Bernh ...
-
Schmidt, Peter M ...
-
Monoranu, Cameli ...
-
Alafuzoff, Irina
-
Marklund, Niklas
-
Nolte, Marc W.
-
Siren, Anna-Leen ...
-
Kleinschnitz, Ch ...
-
visa färre...
- Artiklar i publikationen
-
Annals of Neurol ...
- Av lärosätet
-
Uppsala universitet