The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

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Netterberg, IdaUppsala universitet,Institutionen för farmaceutisk biovetenskap (författare)

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Artikel/kapitelEngelska2018

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2018-01-18
Wiley,2018
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-343812
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343812URI
https://doi.org/10.1111/bcp.13477DOI

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Språk:engelska
Sammanfattning på:engelska

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AIMS: Early identification of patients with febrile neutropenia (FN) is desirable for initiation of preventive treatment, such as with antibiotics. In this study, the time courses of two inflammation biomarkers, interleukin (IL)-6 and C-reactive protein (CRP), following adjuvant chemotherapy of breast cancer, were characterized. The potential to predict development of FN by IL-6 and CRP, and other model-derived and clinical variables, was explored.METHODS: The IL-6 and CRP time courses in cycles 1 and 4 of breast cancer treatment were described by turnover models where the probability for an elevated production following initiation of chemotherapy was estimated. Parametric time-to-event models were developed to describe FN occurrence to assess: (i) predictors available before chemotherapy is initiated; (ii) predictors available before FN occurs; and (iii) predictors available when FN occurs.RESULTS: The IL-6 and CRP time courses were successfully characterized with peak IL-6 typically occurring 2 days prior to CRP peak. Of all evaluated variables the CRP time course was most closely associated with the occurrence of FN. Since the CRP peak typically occurred at the time of FN diagnosis it will, however, have limited value for identifying the need for preventive treatment. The time course of IL-6 was the predictor that could best forecast FN events. Of the variables available at baseline, age was the best, although in comparison a relatively weak, predictor.CONCLUSIONS: The developed models add quantitative knowledge about IL-6 and CRP and their relationship to the development of FN. The study suggests that IL-6 may have potential as a clinical predictor of FN if monitored during myelosuppressive chemotherapy.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
C-reactive protein
NONMEM
adjuvant chemotherapy
febrile neutropenia
interleukin-6

Biuppslag (personer, institutioner, konferenser, titlar ...)

Karlsson, Mats OUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)matskarl (författare)
Nielsen, Elisabet I.,1973-Uppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)elnie838 (författare)
Quartino, Angelica LUppsala universitet,Institutionen för farmaceutisk biovetenskap,Genentech Inc, Dept Clin Pharmacol, Genentech, San Francisco, USA(Swepub:uu)angua424 (författare)
Lindman, HenrikUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)henrlind (författare)
Friberg, Lena EUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo (författare)
Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

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Ingår i:British Journal of Clinical Pharmacology: Wiley84:3, s. 490-5000306-52511365-2125

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Av författaren/redakt...: Netterberg, Ida; Karlsson, Mats O; Nielsen, Elisabe ...; Quartino, Angeli ...; Lindman, Henrik; Friberg, Lena E

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: British Journal ...

Av lärosätet: Uppsala universitet

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