Sökning: WFRF:(Nyberg Lars 1966 ) > Role of dopamine an...
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000 | 04266naa a2200565 4500 | |
001 | oai:gup.ub.gu.se/302924 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-179505 | |
009 | oai:prod.swepub.kib.ki.se:145631769 | |
024 | 7 | a https://gup.ub.gu.se/publication/3029242 URI |
024 | 7 | a https://doi.org/10.1007/s00429-020-02205-42 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1795052 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456317692 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garzón, Benjamínu Karolinska Institutet4 aut |
245 | 1 0 | a Role of dopamine and gray matter density in aging effects and individual differences of functional connectomes |
264 | c 2021-01-09 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a With increasing age, functional connectomes become dissimilar across normal individuals, reflecting heterogenous aging effects on functional connectivity (FC). We investigated the distribution of these effects across the connectome and their relationship with age-related differences in dopamine (DA) D1 receptor availability and gray matter density (GMD). With this aim, we determined aging effects on mean and interindividual variance of FC using fMRI in 30 younger and 30 older healthy subjects and mapped the contribution of each connection to the patterns of age-related similarity loss. Aging effects on mean FC accounted mainly for the dissimilarity between connectomes of younger and older adults, and were related, across brain regions, to aging effects on DA D1 receptor availability. Aging effects on the variance of FC indicated a global increase in variance with advancing age, explained connectome dissimilarity among older subjects and were related to aging effects on variance of GMD. The relationship between aging and the similarity of connectomes can thus be partly explained by age differences in DA modulation and gray matter structure. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
653 | a Aging | |
653 | a Dopamine | |
653 | a fMRI | |
653 | a Functional connectome | |
653 | a PET | |
653 | a Dopamine | |
700 | 1 | a Lövdén, Martin,d 1972u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology4 aut0 (Swepub:gu)xlovma |
700 | 1 | a de Boer, Lieke4 aut |
700 | 1 | a Axelsson, Jan,d 1966-u Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)jaax0004 |
700 | 1 | a Riklund, Katrine,c MD, PhD, Professor,d 1963-u Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)kaah0001 |
700 | 1 | a Bäckman, Larsu Karolinska Institutet4 aut |
700 | 1 | a Nyberg, Lars,d 1966-u Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi4 aut0 (Swepub:umu)lany0001 |
700 | 1 | a Guitart-Masip, Marcu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Psykologiska institutionen4 org |
773 | 0 | t Brain Structure and Functiond : Springer Science and Business Media LLCg 226, s. 743-758q 226<743-758x 1863-2653x 1863-2661 |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00429-020-02205-4.pdf |
856 | 4 | u https://doi.org/10.1007/s00429-020-02205-4y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1526202/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/302924 |
856 | 4 8 | u https://doi.org/10.1007/s00429-020-02205-4 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179505 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145631769 |
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