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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004350naa a2200373 4500
001oai:DiVA.org:oru-46363
003SwePub
008151102s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-463632 URI
0247 a https://doi.org/10.1099/mic.0.043406-02 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rosberg-Cody, Evau Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
2451 0a Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice
264 1a Berks, United Kingdom :b Society for General Microbiology,c 2011
338 a print2 rdacarrier
520 a We have previously demonstrated that oral administration of a metabolically active Bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (CLA), resulted in modulation of the fatty acid composition of the host, including significantly elevated concentrations of c9, t11 CLA and omega-3 (n-3) fatty acids in liver and adipose tissue. In this study, we investigated whether a recombinant lactobacillus expressing linoleic acid isomerase (responsible for production of t10, c12 CLA) from Propionibacterium acnes (PAI) could influence the fatty acid composition of different tissues in a mouse model. Linoleic-acid-supplemented diets (2 %, w/w) were fed in combination with either a recombinant t10, c12 CLA-producing Lactobacillus paracasei NFBC 338 (Lb338), or an isogenic (vector-containing) control strain, to BALB/c mice for 8 weeks. A third group of mice received linoleic acid alone (2 %, w/w). Tissue fatty acid composition was assessed by GLC at the end of the trial. Ingestion of the strain expressing linoleic acid isomerase was associated with a 4-fold increase (P<0.001) in t10, c12 CLA in adipose tissues of the mice when compared with mice that received the isogenic non-CLA-producing strain. The livers of the mice that received the recombinant CLA-producing Lb338 also contained a 2.5-fold (albeit not significantly) higher concentration of t10, c12 CLA, compared to the control group. These data demonstrate that a single gene (encoding linoleic acid isomerase) expressed in an intestinal microbe can influence the fatty acid composition of host fat.
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
7001 a Stanton, Catherineu Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a O'Mahony, Liamu Alimentary Pharmabiotic Centre (APC), Cork, Ireland4 aut
7001 a Wall, Rebecca,d 1979-u Alimentary Pharmabiotic Centre (APC), Cork, Ireland,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)rwl
7001 a Shanahan, Fergusu Alimentary Pharmabiotic Centre (APC), Cork, Ireland4 aut
7001 a Quigley, Eamonn M.u Alimentary Pharmabiotic Centre (APC), Cork, Ireland4 aut
7001 a Fitzgerald, Gerald F.u Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland4 aut
7001 a Ross, R. Paulu Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7102 a Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Irelandb Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 org
7730 t Microbiologyd Berks, United Kingdom : Society for General Microbiologyg 157:2, s. 609-615q 157:2<609-615x 1350-0872x 1465-2080
8564 u http://mic.microbiologyresearch.org/deliver/fulltext/micro/157/2/609.pdf?itemId=/content/journal/micro/10.1099/mic.0.043406-0&mimeType=pdf&isFastTrackArticle=
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-46363
8564 8u https://doi.org/10.1099/mic.0.043406-0

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