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Glycoengineered ker...
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection
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Bagdonaite, Ieva (author)
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Marinova, Irina N. (author)
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Rudjord-Levann, Asha M. (author)
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Pallesen, Emil M.H. (author)
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King-Smith, Sarah L. (author)
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Karlsson, Richard (author)
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Rømer, Troels B. (author)
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Chen, Yen Hsi (author)
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Miller, Rebecca L. (author)
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- Olofsson, Sigvard, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Nordén, Rickard, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Dabelsteen, Sally (author)
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Wandall, Hans H. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nature Communications. - 2041-1723. ; 14:1
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Viral and host glycans represent an understudied aspect of host-pathogen interactions, despite potential implications for treatment of viral infections. This is due to lack of easily accessible tools for analyzing glycan function in a meaningful context. Here we generate a glycoengineered keratinocyte library delineating human glycosylation pathways to uncover roles of specific glycans at different stages of herpes simplex virus type 1 (HSV-1) infectious cycle. We show the importance of cellular glycosaminoglycans and glycosphingolipids for HSV-1 attachment, N-glycans for entry and spread, and O-glycans for propagation. While altered virion surface structures have minimal effects on the early interactions with wild type cells, mutation of specific O-glycosylation sites affects glycoprotein surface expression and function. In conclusion, the data demonstrates the importance of specific glycans in a clinically relevant human model of HSV-1 infection and highlights the utility of genetic engineering to elucidate the roles of specific viral and cellular carbohydrate structures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- art (subject category)
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Bagdonaite, Ieva
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Marinova, Irina ...
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Rudjord-Levann, ...
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Pallesen, Emil M ...
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King-Smith, Sara ...
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Karlsson, Richar ...
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show more...
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Rømer, Troels B.
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Chen, Yen Hsi
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Miller, Rebecca ...
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Olofsson, Sigvar ...
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Nordén, Rickard, ...
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Bergström, Tomas ...
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Dabelsteen, Sall ...
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Wandall, Hans H.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Nature Communica ...
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University of Gothenburg