A population-based study of head injury, cognitive function and pathological markers.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Ourselin Sebastien) > A population-based ...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04167naa a2200589 4500
001		oai:gup.ub.gu.se/303487
003		SwePub
008		240528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3034872 URI
024	7	a https://doi.org/10.1002/acn3.513312 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a James, Sarah-Naomi4 aut
245	1 0	a A population-based study of head injury, cognitive function and pathological markers.
264		c 2021-03-11
264	1	b Wiley,c 2021
520		a To assess associations between head injury (HI) with loss of consciousness (LOC), ageing and markers of later-life cerebral pathology; and to explore whether those effects may help explain subtle cognitive deficits in dementia-free individuals.Participants (n=502, age=69-71) from the 1946 British Birth Cohort underwent cognitive testing (subtests of Preclinical Alzheimer Cognitive Composite), 18 F-florbetapir Aβ-PET and MR imaging. Measures include Aβ-PET status, brain, hippocampal and white matter hyperintensity (WMH) volumes, normal appearing white matter (NAWM) microstructure, Alzheimer's disease (AD)-related cortical thickness, and serum neurofilament light chain (NFL). LOC HI metrics include HI occurring: (i) >15years prior to the scan (ii) anytime up to age 71.Compared to those with no evidence of an LOC HI, only those reporting an LOC HI>15years prior (16%, n=80) performed worse on cognitive tests at age 69-71, taking into account premorbid cognition, particularly on the digit-symbol substitution test (DSST). Smaller brain volume (BV) and adverse NAWM microstructural integrity explained 30% and 16% of the relationship between HI and DSST, respectively. We found no evidence that LOC HI was associated with Aβ load, hippocampal volume, WMH volume, AD-related cortical thickness or NFL (all p>0.01).Having a LOC HI aged 50's and younger was linked with lower later-life cognitive function at age ~70 than expected. This may reflect a damaging but small impact of HI; explained in part by smaller BV and different microstructure pathways but not via pathology related to AD (amyloid, hippocampal volume, AD cortical thickness) or ongoing neurodegeneration (serum NFL).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Nicholas, Jennifer M4 aut
700	1	a Lane, Christopher A4 aut
700	1	a Parker, Thomas D4 aut
700	1	a Lu, Kirsty4 aut
700	1	a Keshavan, Ashvini4 aut
700	1	a Buchanan, Sarah M4 aut
700	1	a Keuss, Sarah E4 aut
700	1	a Murray-Smith, Heidi4 aut
700	1	a Wong, Andrew4 aut
700	1	a Cash, David M4 aut
700	1	a Malone, Ian B4 aut
700	1	a Barnes, Josephine4 aut
700	1	a Sudre, Carole H4 aut
700	1	a Coath, William4 aut
700	1	a Prosser, Lloyd4 aut
700	1	a Ourselin, Sebastien4 aut
700	1	a Modat, Marc4 aut
700	1	a Thomas, David L4 aut
700	1	a Cardoso, Jorge4 aut
700	1	a Heslegrave, Amanda4 aut
700	1	a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
700	1	a Crutch, Sebastian J4 aut
700	1	a Schott, Jonathan M4 aut
700	1	a Richards, Marcus4 aut
700	1	a Fox, Nick C4 aut
710	2	a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Annals of clinical and translational neurologyd : Wileyg 8:4, s. 842-856q 8:4<842-856x 2328-9503
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51331
856	4 8	u https://gup.ub.gu.se/publication/303487
856	4 8	u https://doi.org/10.1002/acn3.51331

Hitta via bibliotek

Annals of clinical and translational neurology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Annals of clinic ...

Av lärosätet: Göteborgs universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se