Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.

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Fältnamn	Indikatorer	Metadata
000		04535naa a2200673 4500
001		oai:gup.ub.gu.se/232586
003		SwePub
008		240910s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2325862 URI
024	7	a https://doi.org/10.1016/j.bbmt.2016.01.0122 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kumar, Rajat4 aut
245	1 0	a Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.
264	1	b Elsevier BV,c 2016
520		a Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita and region/countries into 4 groups. Groups analyzed were high-income countries (HIC), which were further divided into United States-Canada (n=486) and other HIC (n=1264); upper middle income (UMIC) (n=482); and combined lower-middle, low-income countries (LM-LIC) (n=142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared with PBSCs in all countries or BM in UMIC or LM-LIC (P<.001). There was no significant difference in OS between BM and PBSCs in UMIC (P=.32) or LM-LIC (P=.23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSCs compared with BM (97% versus 77%, P<.001). Chronic graft-versus-host disease was significantly higher with PBSCs in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSCs may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
700	1	a Kimura, Fumihiko4 aut
700	1	a Ahn, Kwang Woo4 aut
700	1	a Hu, Zhen-Huan4 aut
700	1	a Kuwatsuka, Yachiyo4 aut
700	1	a Klein, John P4 aut
700	1	a Pasquini, Marcelo4 aut
700	1	a Miyamura, Koichi4 aut
700	1	a Kato, Koji4 aut
700	1	a Yoshimi, Ayami4 aut
700	1	a Inamoto, Yoshihiro4 aut
700	1	a Ichinohe, Tatsuo4 aut
700	1	a Wood, William Allen4 aut
700	1	a Wirk, Baldeep4 aut
700	1	a Seftel, Matthew4 aut
700	1	a Rowlings, Philip4 aut
700	1	a Marks, David I4 aut
700	1	a Schultz, Kirk R4 aut
700	1	a Gupta, Vikas4 aut
700	1	a Dedeken, Laurence4 aut
700	1	a George, Biju4 aut
700	1	a Cahn, Jean-Yves4 aut
700	1	a Szer, Jeff4 aut
700	1	a Lee, Jong Wook4 aut
700	1	a Ho, Aloysius Y L4 aut
700	1	a Fasth, Anders,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xfasan
700	1	a Hahn, Theresa4 aut
700	1	a Khera, Nandita4 aut
700	1	a Dalal, Jignesh4 aut
700	1	a Bonfim, Carmem4 aut
700	1	a Aljurf, Mahmoud4 aut
700	1	a Atsuta, Yoshiko4 aut
700	1	a Saber, Wael4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org
773	0	t Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantationd : Elsevier BVg 22:5, s. 932-940q 22:5<932-940x 1523-6536
773	0	t Biology of Blood and Marrow Transplantationd : Elsevier BVg 22:5, s. 932-940q 22:5<932-940x 1083-8791
856	4	u http://www.bbmt.org/article/S1083879116000525/pdf
856	4 8	u https://gup.ub.gu.se/publication/232586
856	4 8	u https://doi.org/10.1016/j.bbmt.2016.01.012

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