WFRF:(Pauli H.)
Sökning: WFRF:(Pauli H.) > (2005-2009) > Efficacy of recombi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04860naa a2200889 4500 | |
| 001 | oai:gup.ub.gu.se/81813 | |
| 003 | SwePub | |
| 008 | 240528s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/818132 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jaci.2008.09.0172 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Pauli, Gabrielle4 aut |
| 245 | 1 0 | a Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. |
| 264 | 1 | b Elsevier BV,c 2008 |
| 520 | a BACKGROUND: Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition. OBJECTIVE: To evaluate the effectiveness of a new recombinant birch pollen allergen vaccine in patients with birch pollen allergy. METHODS: A multicenter, randomized, double-blind, placebo-controlled trial was undertaken to compare the following 3 vaccines in 134 adults with birch pollen allergy: recombinant birch pollen allergen vaccine (rBet v 1a), licensed birch pollen extract, natural purified birch pollen allergen (nBet v 1), and placebo. Patients received 12 weekly injections followed by monthly injections of the maintenance dose containing 15 microg Bet v 1 for 2 years. RESULTS: Significant reductions (about 50%) in rhinoconjunctivitis symptoms (rBet v 1, P = .0002; nBet v 1, P = .0006; birch extract, P = .0024), rescue medication (rBet v 1, P = .0011; nBet v 1, P = .0025; birch extract, P = .0063), and skin sensitivities (P < .0001) were observed in the 3 actively treated groups compared with placebo during 2 consecutive pollen seasons. Clinical improvement was accompanied by marked increases in Bet v 1-specific IgG levels, which were higher in the rBet v 1-treated group than in the birch and nBet v 1-treated groups. New IgE specificities were induced in 3 of 29 patients treated with birch pollen extract, but in none of the 32 rBet v 1-treated or 29 nBet v 1-treated patients. No severe systemic adverse events were observed in the rBet v 1-treated group. CONCLUSION: The rBet v 1-based vaccine was safe and effective in treating birch pollen allergy, and induced a highly specific immune response. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
| 653 | a Adult | |
| 653 | a Allergens | |
| 653 | a adverse effects | |
| 653 | a immunology | |
| 653 | a Anti-Allergic Agents | |
| 653 | a therapeutic use | |
| 653 | a Betula | |
| 653 | a adverse effects | |
| 653 | a immunology | |
| 653 | a Conjunctivitis | |
| 653 | a Allergic | |
| 653 | a immunology | |
| 653 | a therapy | |
| 653 | a Desensitization | |
| 653 | a Immunologic | |
| 653 | a Double-Blind Method | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Pollen | |
| 653 | a adverse effects | |
| 653 | a immunology | |
| 653 | a Recombinant Proteins | |
| 653 | a immunology | |
| 653 | a therapeutic use | |
| 653 | a Rhinitis | |
| 653 | a Allergic | |
| 653 | a Seasonal | |
| 653 | a immunology | |
| 653 | a therapy | |
| 653 | a Vaccines | |
| 653 | a immunology | |
| 653 | a therapeutic use | |
| 653 | a Young Adult | |
| 700 | 1 | a Larsen, Tina H4 aut |
| 700 | 1 | a Rak, Sabina,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xraksa |
| 700 | 1 | a Horak, Friedrich4 aut |
| 700 | 1 | a Pastorello, Elide4 aut |
| 700 | 1 | a Valenta, Rudolph4 aut |
| 700 | 1 | a Purohit, Ashok4 aut |
| 700 | 1 | a Arvidsson, Monica,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xarvmo |
| 700 | 1 | a Kavina, Alexander4 aut |
| 700 | 1 | a Schroeder, Jan W4 aut |
| 700 | 1 | a Mothes, Nadine4 aut |
| 700 | 1 | a Spitzauer, Susanne4 aut |
| 700 | 1 | a Montagut, Armelle4 aut |
| 700 | 1 | a Galvain, Sylvie4 aut |
| 700 | 1 | a Melac, Michel4 aut |
| 700 | 1 | a André, Claude4 aut |
| 700 | 1 | a Poulsen, Lars K4 aut |
| 700 | 1 | a Malling, Hans-Jorgen4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin4 org |
| 773 | 0 | t The Journal of allergy and clinical immunologyd : Elsevier BVg 122:5, s. 951-60q 122:5<951-60x 1097-6825x 0091-6749 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/81813 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jaci.2008.09.017 |
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