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Sökning: WFRF:(Pavlova Tatiana V) > Integrin α9 gene pr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005379naa a2200481 4500
001oai:DiVA.org:liu-122660
003SwePub
008151113s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132270853
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1226602 URI
0247 a https://doi.org/10.18632/oncotarget.51542 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1322708532 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nawaz, Imranu Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Department of Microbiology, Faculty of Life Sciences, University of Balochistan, Quetta, Pakistan4 aut
2451 0a Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma
264 c 2015-09-08
264 1a Albany, NY, United States :b Impact Journals LLC,c 2015
338 a electronic2 rdacarrier
500 a Funding Agencies|Cancerfonden; Cancerforeningen in Stockholm; National Natural Science Foundation of China [81202135]; Project for the Development of University of Balochistan, Quetta, Pakistan
520 a Epigenetic silencing of tumor suppressor genes (TSGs) by promoter methylation can be an early event in the multi-step process of carcinogenesis. Human chromosome 3 contains clusters of TSGs involved in many cancer types including nasopharyngeal carcinoma (NPC), the most common cancer in Southern China. Among ten candidate TSGs identified in chromosome 3 using NotI microarray, ITGA9 and WNT7A could be validated. 5-aza-2 deoxycytidine treatment restored the expression of ITGA9 and WNT7A in two NPC cell lines. Immunostaining showed strong expression of these genes in the membrane and cytoplasm of adjacent control nasopharyngeal epithelium cells, while they were weakly expressed in NPC tumor cells. The ITGA9 promoter showed marked differentially methylation between tumor and control tissue, whereas no differentially methylation could be detected for the WNT7A promoter. The expression level of ITGA9 in NPC tumors was downregulated 4.9-fold, compared to the expression in control. ITGA9 methylation was detected by methylation specific PCR (MSP) in 56% of EBV positive NPC-cases with 100% specificity. Taken together, this suggests that ITGA9 might be a TSG in NPC that is involved in tumor cell biology. The possibility of using ITGA9 methylation as a marker for early detection of NPC should further be explored.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a nasopharyngeal carcinoma; ITGA9; DNA methylation; notl microarrays; epigenetics
7001 a Hu, Li-Fuu Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Du, Zi-Mingu Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; State Key Laboratory of Oncology in South China, and Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, P.R. China4 aut
7001 a Moumad, Khalidu Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco4 aut
7001 a Ignatyev, Ilyau Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Pavlova, Tatiana V.u Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Kashuba, Vladimiru Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Almgren, Malinu Karolinska Institutet,Department Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Centre for Molecular Medicine, Stockholm, Sweden4 aut
7001 a Zabarovsky, Eugene R.u Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:liu)eugza90
7001 a Ernberg, Ingemaru Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 aut
7102 a Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Department of Microbiology, Faculty of Life Sciences, University of Balochistan, Quetta, Pakistanb Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden4 org
7730 t Oncotargetd Albany, NY, United States : Impact Journals LLCg 6:31, s. 31493-31507q 6:31<31493-31507x 1949-2553
8564 u https://liu.diva-portal.org/smash/get/diva2:871717/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5154&path%5B%5D=13868
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122660
8564 8u https://doi.org/10.18632/oncotarget.5154
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132270853

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