From transcriptional complexity to cellular phenotypes : lessons from yeast

2017-10-11
Stockholm :Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology,2017
electronicrdacarrier

Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine-tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell-to-cell phenotypic variability.

Ingår i:YeastStockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology0749-503X1097-0061

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