Sökning: WFRF:(Pozzilli Paolo) > Serum adipokines as...
Fältnamn | Indikatorer | Metadata |
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000 | 03768naa a2200493 4500 | |
001 | oai:DiVA.org:liu-90075 | |
003 | SwePub | |
008 | 130319s2013 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:126167908 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-900752 URI |
024 | 7 | a https://doi.org/10.1002/dmrr.23782 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1261679082 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nguyet Pham, Minhu University of Dusseldorf, Germany4 aut |
245 | 1 0 | a Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin |
264 | c 2013-02-05 | |
264 | 1 | b John Wiley and Sons,c 2013 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|European Association for the Study of Diabetes (EFSD)||German Diabetes Association (DDG)||Deutsches Zentrum fur Diabetesforschung (DZD) e.V.|| | |
520 | a Background We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes. Methods One hundred and eighteen patients with type 1 diabetes (20.3 +/- 7.5years) diagnosed andlt;5years underwent standardized mixed meal test (MMTT) for 2h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis. Results Patients were divided by their adipokine levels in subgroups above or below the median level (high versus low). High adiponectin levels (andgt;10.6 mu g/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (pandlt;0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (pandlt;0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (pandlt;0.05). Serum adipokines fell during MMTT (pandlt;0.05). Conclusions Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes. | |
653 | a adipokine | |
653 | a adiponectin | |
653 | a C-peptide | |
653 | a leptin | |
653 | a resistin | |
653 | a type 1 diabetes | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Kolb, Hubertu University of Dusseldorf, Germany4 aut |
700 | 1 | a Mandrup-Poulsen, Thomasu University of Copenhagen, Denmark4 aut |
700 | 1 | a Battelino, Tadeju University of Childrens Hospital, Slovenia4 aut |
700 | 1 | a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29 |
700 | 1 | a Pozzilli, Paolou University of Campus BioMed, Italy4 aut |
700 | 1 | a Roden, Michaelu University of Dusseldorf, Germany4 aut |
700 | 1 | a Schloot, Nanette C.u University of Dusseldorf, Germany4 aut |
710 | 2 | a University of Dusseldorf, Germanyb University of Copenhagen, Denmark4 org |
773 | 0 | t Diabetes/Metabolism Research Reviewsd : John Wiley and Sonsg 29:2, s. 166-170q 29:2<166-170x 1520-7552x 1520-7560 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90075 |
856 | 4 8 | u https://doi.org/10.1002/dmrr.2378 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126167908 |
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