Human articular cartilage proteoglycans are not undersulfated in osteoarthritis.

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Fältnamn	Indikatorer	Metadata
000		04490naa a2200565 4500
001		oai:DiVA.org:umu-106638
003		SwePub
008		150726s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1066382 URI
024	7	a https://doi.org/10.1080/030082006010441282 DOI
040		a (SwePub)umu
041		a engb engb -1
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Qu, Cheng-Juan,d 1967-u Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)chqu0007
245	1 0	a Human articular cartilage proteoglycans are not undersulfated in osteoarthritis.
264		c 2009-08-06
264	1	b Informa Healthcare,c 2007
338		a print2 rdacarrier
520		a Chondroitin sulfate is the major constituent of cartilage. Inadequate sulfate availability results in the production of undersulfated proteoglycans. In osteoarthritis, there is a net loss of articular cartilage proteoglycans. Theoretically, it is possible that during the progress of disease undersulfated glycosaminoglycans are synthesized producing proteoglycans with poorer biological properties. In this study, we tested whether in early human osteoarthritic articular cartilage (Mankin's score of 2 and 3) or more advanced disease (Mankin's score over 3), there are proteoglycans that contain a higher relative amount of nonsulfated chondroitin disaccharide isomer in their chondroitin sulfate chains by analyzing the molar ratios of chondroitin sulfate disaccharide isoforms with fluorophore-assisted carbohydrate electrophoresis. Our results indicated that the nonsulfated disaccharide of chondroitin sulfate formed in average only 1-2% of the total chondroitin sulfate. More important, the molar ratio of nonsulfated disaccharide did not appear to be increased in the osteoarthritic articular cartilage. We conclude that undersulfation of articular cartilage proteoglycans is not present in the human osteoarthritic joint.
520		a
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650	7	a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653		a Articular cartilage
653		a chondroitin sulfate
653		a osteoarthritis
653		a proteoglycan
653		a sulfation
653		a biokemi
653		a Biochemistry
653		a cell research
653		a cellforskning
653		a ortopedi
653		a Orthopaedics
700	1	a Rieppo, Jarnou Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut
700	1	a Hyttinen, Mikau Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut
700	1	a Lammi, Mikko,d 1961-u Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)mila0077
700	1	a Kiviranta, Ilkkau Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland4 aut
700	1	a Kurkijärvi, Jattau Department of Physics, University of Kuopio, Kuopio, Finland4 aut
700	1	a Jurvelin, Jukkau Department of Physics, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
700	1	a Töyräs, Juhau Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland4 aut
710	2	a Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finlandb Chondrogenic and Osteogenic Differentiation Group4 org
773	0	t Connective Tissue Researchd : Informa Healthcareg 48:1, s. 27-33q 48:1<27-33x 0300-8207x 1607-8438
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106638
856	4 8	u https://doi.org/10.1080/03008200601044128

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Av författaren/redakt...: Qu, Cheng-Juan, ...; Rieppo, Jarno; Hyttinen, Mika; Lammi, Mikko, 19 ...; Kiviranta, Ilkka; Kurkijärvi, Jatt ...; visa fler...; Jurvelin, Jukka; Töyräs, Juha; visa färre...

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Av lärosätet: Umeå universitet

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