Sökning: WFRF:(Qu Cheng Juan 1967 ) > Human articular car...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04490naa a2200565 4500 | |
001 | oai:DiVA.org:umu-106638 | |
003 | SwePub | |
008 | 150726s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1066382 URI |
024 | 7 | a https://doi.org/10.1080/030082006010441282 DOI |
040 | a (SwePub)umu | |
041 | a engb engb -1 | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Qu, Cheng-Juan,d 1967-u Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)chqu0007 |
245 | 1 0 | a Human articular cartilage proteoglycans are not undersulfated in osteoarthritis. |
264 | c 2009-08-06 | |
264 | 1 | b Informa Healthcare,c 2007 |
338 | a print2 rdacarrier | |
520 | a Chondroitin sulfate is the major constituent of cartilage. Inadequate sulfate availability results in the production of undersulfated proteoglycans. In osteoarthritis, there is a net loss of articular cartilage proteoglycans. Theoretically, it is possible that during the progress of disease undersulfated glycosaminoglycans are synthesized producing proteoglycans with poorer biological properties. In this study, we tested whether in early human osteoarthritic articular cartilage (Mankin's score of 2 and 3) or more advanced disease (Mankin's score over 3), there are proteoglycans that contain a higher relative amount of nonsulfated chondroitin disaccharide isomer in their chondroitin sulfate chains by analyzing the molar ratios of chondroitin sulfate disaccharide isoforms with fluorophore-assisted carbohydrate electrophoresis. Our results indicated that the nonsulfated disaccharide of chondroitin sulfate formed in average only 1-2% of the total chondroitin sulfate. More important, the molar ratio of nonsulfated disaccharide did not appear to be increased in the osteoarthritic articular cartilage. We conclude that undersulfation of articular cartilage proteoglycans is not present in the human osteoarthritic joint. | |
520 | a | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
653 | a Articular cartilage | |
653 | a chondroitin sulfate | |
653 | a osteoarthritis | |
653 | a proteoglycan | |
653 | a sulfation | |
653 | a biokemi | |
653 | a Biochemistry | |
653 | a cell research | |
653 | a cellforskning | |
653 | a ortopedi | |
653 | a Orthopaedics | |
700 | 1 | a Rieppo, Jarnou Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Hyttinen, Mikau Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Lammi, Mikko,d 1961-u Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)mila0077 |
700 | 1 | a Kiviranta, Ilkkau Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland4 aut |
700 | 1 | a Kurkijärvi, Jattau Department of Physics, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Jurvelin, Jukkau Department of Physics, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland4 aut |
700 | 1 | a Töyräs, Juhau Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland4 aut |
710 | 2 | a Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finlandb Chondrogenic and Osteogenic Differentiation Group4 org |
773 | 0 | t Connective Tissue Researchd : Informa Healthcareg 48:1, s. 27-33q 48:1<27-33x 0300-8207x 1607-8438 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106638 |
856 | 4 8 | u https://doi.org/10.1080/03008200601044128 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy