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SCOT :
SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer
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- Robles-Zurita, Jose (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
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- Boyd, Kathleen A. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
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- Briggs, Andrew H. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
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- Iveson, Timothy (författare)
- Southampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
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- Kerr, Rachel S. (författare)
- Univ Oxford, Dept Oncol, Oxford, England
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- Saunders, Mark P. (författare)
- Christie Hosp, Manchester, Lancs, England
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- Cassidy, Jim (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
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- Hollander, Niels Henrik (författare)
- Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
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- Tabernero, Josep (författare)
- Univ Autonoma Barcelona, CIBERONC, Vall dHebron Univ Hosp, Barcelona, Spain;Univ Autonoma Barcelona, CIBERONC, Inst Oncol VHIO, Barcelona, Spain
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- Segelov, Eva (författare)
- Australasian Gastrointestinal Trials Grp AGITG, Melbourne, Vic, Australia;Monash Univ, Melbourne, Vic, Australia;Monash Hlth, Melbourne, Vic, Australia
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Harkin, Andrea (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
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- Allan, Karen (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
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- McQueen, John (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
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- Pearson, Sarah (författare)
- Univ Oxford, OCTO, Dept Oncol, Oxford, England
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- Waterston, Ashita (författare)
- Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland
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- Medley, Louise (författare)
- Royal United Hosp, Bath, Avon, England
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- Wilson, Charles (författare)
- Addenbrookes Hosp, Cambridge, England
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- Ellis, Richard (författare)
- Royal Cornwall Hosp NHS Trust, Truro, Cornwall, England
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- Essapen, Sharadah (författare)
- Royal Surrey Cty Hosp NHS Fdn Trust, St Lukes Canc Ctr, Guildford, Surrey, England
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- Dhadda, Amandeep S. (författare)
- Castle Hill Hosp, Kingston Upon Hull, N Humberside, England
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- Hughes, Rob (författare)
- Mt Vernon Canc Ctr, Northwood, Middx, England
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- Falk, Stephen (författare)
- Bristol Canc Inst, Bristol, Avon, England
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- Raouf, Sherif (författare)
- Barking Havering & Redbridge Univ Hosp NHS Trust, Barking, England
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- Rees, Charlotte (författare)
- Southampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
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- Olesen, Rene K. (författare)
- Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
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- Propper, David (författare)
- Queen Mary Univ London, Barts Canc Inst, London, England
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- Bridgewater, John (författare)
- UCL, London, England
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- Azzabi, Ashraf (författare)
- Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
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- Farrugia, David (författare)
- Cheltenham Gen Hosp, Gloucestershire Oncol Ctr, Cheltenham, Glos, England
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- Webb, Andrew (författare)
- Brighton & Sussex Univ Hosp Trust, Brighton, E Sussex, England
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- Cunningham, David (författare)
- Royal Marsden, London, England
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- Hickish, Tamas (författare)
- Bournemouth Univ, Poole Hosp, Bournemouth, Dorset, England
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- Weaver, Andrew (författare)
- Oxford Univ Hosp Fdn Trust, Churchill Hosp, Oxford, England
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- Gollins, Simon (författare)
- North Wales Canc Treatment Ctr, Rhyl, Wales
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- Wasan, Harpreet S. (författare)
- Imperial Coll London, Hammersmith Hosp, London, England
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- Paul, James (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
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(creator_code:org_t)
- 2018-11-13
- 2018
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 119:11, s. 1332-1338
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Robles-Zurita, J ...
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Boyd, Kathleen A ...
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Briggs, Andrew H ...
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Iveson, Timothy
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Kerr, Rachel S.
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Saunders, Mark P ...
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visa fler...
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Cassidy, Jim
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Hollander, Niels ...
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Tabernero, Josep
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Segelov, Eva
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Glimelius, Bengt
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Harkin, Andrea
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Allan, Karen
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McQueen, John
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Pearson, Sarah
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Waterston, Ashit ...
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Medley, Louise
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Wilson, Charles
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Ellis, Richard
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Essapen, Sharada ...
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Dhadda, Amandeep ...
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Hughes, Rob
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Falk, Stephen
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Raouf, Sherif
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Rees, Charlotte
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Olesen, Rene K.
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Propper, David
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Bridgewater, Joh ...
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Azzabi, Ashraf
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Farrugia, David
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Webb, Andrew
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Cunningham, Davi ...
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Hickish, Tamas
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Weaver, Andrew
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Gollins, Simon
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Wasan, Harpreet ...
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Paul, James
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visa färre...
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