WFRF:(Regitz Zagrosek V)
Sökning: WFRF:(Regitz Zagrosek V) > Female sex and estr...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03041naa a2200373 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:120483913 | |
| 003 | SwePub | |
| 008 | 240701s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1204839132 URI |
| 024 | 7 | a https://doi.org/10.1152/ajpregu.00825.20092 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fliegner, D4 aut |
| 245 | 1 0 | a Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload |
| 264 | 1 | b American Physiological Society,c 2010 |
| 520 | a We investigated sex differences and the role of estrogen receptor-β (ERβ) on myocardial hypertrophy in a mouse model of pressure overload. We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ERβ knockout (ERβ−/−) mice. All mice were characterized by echocardiography and hemodynamic measurements and were killed 9 wk after surgery. Left ventricular (LV) samples were analyzed by microarray profiling, real-time RT-PCR, and histology. After 9 wk, WT males showed more hypertrophy and heart failure signs than WT females. Notably, WT females developed a concentric form of hypertrophy, while males developed eccentric hypertrophy. ERβ deletion augmented the TAC-induced increase in cardiomyocyte diameter in both sexes. Gene expression profiling revealed that WT male hearts had a stronger induction of matrix-related genes and a stronger repression of mitochondrial genes than WT female hearts. ERβ−/− mice exhibited a different transcriptional response. ERβ−/−/TAC mice of both sexes exhibited induction of proapoptotic genes with a stronger expression in ERβ−/− males. Cardiac fibrosis was more pronounced in male WT/TAC than in female mice. This difference was abolished in ERβ−/− mice. The number of apoptotic nuclei was increased in both sexes of ERβ−/−/TAC mice, most prominent in males. Female sex offers protection against ventricular chamber dilation in the TAC model. Both female sex and ERβ attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure. | |
| 700 | 1 | a Schubert, C4 aut |
| 700 | 1 | a Penkalla, A4 aut |
| 700 | 1 | a Witt, H4 aut |
| 700 | 1 | a Kararigas, G4 aut |
| 700 | 1 | a Dworatzek, E4 aut |
| 700 | 1 | a Staub, E4 aut |
| 700 | 1 | a Martus, P4 aut |
| 700 | 1 | a Noppinger, PR4 aut |
| 700 | 1 | a Kintscher, U4 aut |
| 700 | 1 | a Gustafsson, JAu Karolinska Institutet4 aut |
| 700 | 1 | a Regitz-Zagrosek, V4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t American journal of physiology. Regulatory, integrative and comparative physiologyd : American Physiological Societyg 298:6, s. R1597-R1606q 298:6<R1597-R1606x 1522-1490x 0363-6119 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120483913 |
| 856 | 4 8 | u https://doi.org/10.1152/ajpregu.00825.2009 |
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