Sökning: WFRF:(Ronckers Cecile M.) > Risk of Soft-Tissue...
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000 | 06895naa a2200793 4500 | |
001 | oai:lup.lub.lu.se:ffaaca2a-fb8a-4e3e-b9d9-1f7fd6ca922a | |
003 | SwePub | |
008 | 180508s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/ffaaca2a-fb8a-4e3e-b9d9-1f7fd6ca922a2 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djx2352 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bright, Chloe Ju University of Birmingham4 aut |
245 | 1 0 | a Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe |
264 | c 2017-11-20 | |
264 | 1 | b Oxford University Press (OUP),c 2018 |
300 | a 12 s. | |
520 | a Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma.Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Hawkins, Mike Mu University of Birmingham4 aut |
700 | 1 | a Winter, David Lu University of Birmingham4 aut |
700 | 1 | a Alessi, Danielau University of Turin4 aut |
700 | 1 | a Allodji, Rodrigue S4 aut |
700 | 1 | a Bagnasco, Francesca4 aut |
700 | 1 | a Bárdi, Edit4 aut |
700 | 1 | a Bautz, Andrea4 aut |
700 | 1 | a Byrne, Julianne4 aut |
700 | 1 | a Feijen, Elizabeth A M4 aut |
700 | 1 | a Fidler, Miranda M4 aut |
700 | 1 | a Garwicz, Stanislawu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)st6750ga |
700 | 1 | a Grabow, Desiree4 aut |
700 | 1 | a Gudmundsdottir, Thorgerdur4 aut |
700 | 1 | a Guha, Joyeeta4 aut |
700 | 1 | a Haddy, Nadia4 aut |
700 | 1 | a Jankovic, Momcilo4 aut |
700 | 1 | a Kaatsch, Peter4 aut |
700 | 1 | a Kaiser, Melanie4 aut |
700 | 1 | a Kuehni, Claudia E4 aut |
700 | 1 | a Linge, Helenau Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Late effects after childhood cancer treatment,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-hjo |
700 | 1 | a Øfstaas, Hilde4 aut |
700 | 1 | a Ronckers, Cecile M4 aut |
700 | 1 | a Skinner, Roderick4 aut |
700 | 1 | a Teepen, Jop C4 aut |
700 | 1 | a Terenziani, Monica4 aut |
700 | 1 | a Vu-Bezin, Giao4 aut |
700 | 1 | a Wesenberg, Finn4 aut |
700 | 1 | a Wiebe, Thomasu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-twi |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Jakab, Zsuzsanna4 aut |
700 | 1 | a Haupt, Riccardo4 aut |
700 | 1 | a Lähteenmäki, Päivi4 aut |
700 | 1 | a Zaletel, Lorna Zadravecu Institute of Oncology, Ljubljana4 aut |
700 | 1 | a Kuonen, Rahelu Swiss Childhood Cancer Registry4 aut |
700 | 1 | a Winther, Jeanette Fu Danish Cancer Society4 aut |
700 | 1 | a de Vathaire, Florentu Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Kremer, Leontien Cu Princess Maxima Center for Pediatric Oncology/Hematology4 aut |
700 | 1 | a Hjorth, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-lhj |
700 | 1 | a Reulen, Raoul Cu University of Birmingham4 aut |
710 | 2 | a University of Birminghamb University of Turin4 org |
710 | 2 | a PanCareSurFup Consortium |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 110:6q 110:6x 1460-2105x 0027-8874 |
856 | 4 | u http://dx.doi.org/10.1093/jnci/djx235x freey FULLTEXT |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/110/6/649/25041826/djx235.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/ffaaca2a-fb8a-4e3e-b9d9-1f7fd6ca922a |
856 | 4 8 | u https://doi.org/10.1093/jnci/djx235 |
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