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Non-invasive electr...
Non-invasive electrical brain stimulation for vision restoration after stroke: An exploratory randomized trial (REVIS)
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Raty, S. (författare)
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Borrmann, C. (författare)
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Granata, G. (författare)
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visa fler...
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Cardenas-Morales, L. (författare)
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Schoenfeld, A. (författare)
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Sailer, M. (författare)
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Silvennoinen, K. (författare)
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Holopainen, J. (författare)
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De Rossi, F. (författare)
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Antal, A. (författare)
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Rossini, P. M. (författare)
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- Tatlisumak, Turgut (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Sabel, B. A. (författare)
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- Engelska.
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Ingår i: Restorative Neurology and Neuroscience. - : IOS Press. - 0922-6028 .- 1878-3627. ; 39:3, s. 221-235
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Occipital strokes often cause permanent homonymous hemianopia leading to significant disability. In previous studies, non-invasive electrical brain stimulation (NIBS) has improved vision after optic nerve damage and in combination with training after stroke. Objective: We explored different NIBS modalities for rehabilitation of hemianopia after chronic stroke. Methods: In a randomized, double-blinded, sham-controlled, three-armed trial, altogether 56 patients with homonymous hemianopia were recruited. The three experiments were: i) repetitive transorbital alternating current stimulation (rtACS, n=8) vs. rtACS with prior cathodal transcranial direct current stimulation over the intact visual cortex (tDCS/rtACS, n=8) vs. sham (n = 8); ii) rtACS (n = 9) vs. sham (n = 9); and iii) tDCS of the visual cortex (n = 7) vs. sham (n = 7). Visual functions were evaluated before and after the intervention, and after eight weeks follow-up. The primary outcome was change in visual field assessed by high-resolution and standard perimetries. The individual modalities were compared within each experimental arm. Results: Primary outcomes in Experiments 1 and 2 were negative. Only significant between-group change was observed in Experiment 3, where tDCS increased visual field of the contralesional eye compared to sham. tDCS/rtACS improved dynamic vision, reading, and visual field of the contralesional eye, but was not superior to other groups. rtACS alone increased foveal sensitivity, but was otherwise ineffective. All trial-related procedures were tolerated well. Conclusions: This exploratory trial showed safety but no main effect of NIBS on vision restoration after stroke. However, tDCS and combined tDCS/rtACS induced improvements in visually guided performance that need to be confirmed in larger-sample trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Electrical stimulation
- homonymous hemianopia
- randomized controlled
- trial
- rehabilitation
- occipital stroke
- vision restoration
- alternating-current stimulation
- visual function
- hemianopia
- recovery
- field
- sensitivity
- plasticity
- Neurosciences & Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Raty, S.
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Borrmann, C.
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Granata, G.
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Cardenas-Morales ...
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Schoenfeld, A.
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Sailer, M.
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visa fler...
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Silvennoinen, K.
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Holopainen, J.
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De Rossi, F.
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Antal, A.
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Rossini, P. M.
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Tatlisumak, Turg ...
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Sabel, B. A.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Restorative Neur ...
- Av lärosätet
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Göteborgs universitet