Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.

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Fältnamn	Indikatorer	Metadata
000		06528naa a2201201 4500
001		oai:gup.ub.gu.se/304287
003		SwePub
008		240528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:146459691
024	7	a https://gup.ub.gu.se/publication/3042872 URI
024	7	a https://doi.org/10.1038/s41380-021-01098-x2 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464596912 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a McWhinney, Sean R4 aut
245	1 0	a Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.
264		c 2021-04-16
264	1	b Springer Science and Business Media LLC,c 2021
520		a Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediatedby BMI (Z=2.73, p=0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Abé, Christophu Karolinska Institutet4 aut
700	1	a Alda, Martin4 aut
700	1	a Benedetti, Francesco4 aut
700	1	a Bøen, Erlend4 aut
700	1	a Del Mar Bonnin, Caterina4 aut
700	1	a Borgers, Tiana4 aut
700	1	a Brosch, Katharina4 aut
700	1	a Canales-Rodríguez, Erick J4 aut
700	1	a Cannon, Dara M4 aut
700	1	a Dannlowski, Udo4 aut
700	1	a Díaz-Zuluaga, Ana M4 aut
700	1	a Elvsåshagen, Torbjørn4 aut
700	1	a Eyler, Lisa T4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Goikolea, Jose M4 aut
700	1	a Goltermann, Janik4 aut
700	1	a Grotegerd, Dominik4 aut
700	1	a Haarman, Bartholomeus C M4 aut
700	1	a Hahn, Tim4 aut
700	1	a Howells, Fleur M4 aut
700	1	a Ingvar, Martinu Karolinska Institutet4 aut
700	1	a Kircher, Tilo T J4 aut
700	1	a Krug, Axel4 aut
700	1	a Kuplicki, Rayus T4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lemke, Hannah4 aut
700	1	a Liberg, Benny4 aut
700	1	a Lopez-Jaramillo, Carlos4 aut
700	1	a Malt, Ulrik F4 aut
700	1	a Martyn, Fiona M4 aut
700	1	a Mazza, Elena4 aut
700	1	a McDonald, Colm4 aut
700	1	a McPhilemy, Genevieve4 aut
700	1	a Meier, Sandra4 aut
700	1	a Meinert, Susanne4 aut
700	1	a Meller, Tina4 aut
700	1	a Melloni, Elisa M T4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Nabulsi, Leila4 aut
700	1	a Nenadic, Igor4 aut
700	1	a Opel, Nils4 aut
700	1	a Ophoff, Roel A4 aut
700	1	a Overs, Bronwyn J4 aut
700	1	a Pfarr, Julia-Katharina4 aut
700	1	a Pineda-Zapata, Julian A4 aut
700	1	a Pomarol-Clotet, Edith4 aut
700	1	a Raduà, Joaquimu Karolinska Institutet4 aut
700	1	a Repple, Jonathan4 aut
700	1	a Richter, Maike4 aut
700	1	a Ringwald, Kai G4 aut
700	1	a Roberts, Gloria4 aut
700	1	a Salvador, Raymond4 aut
700	1	a Savitz, Jonathan4 aut
700	1	a Schmitt, Simon4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Sim, Kang4 aut
700	1	a Stein, Dan J4 aut
700	1	a Stein, Frederike4 aut
700	1	a Temmingh, Henk S4 aut
700	1	a Thiel, Katharina4 aut
700	1	a van Haren, Neeltje E M4 aut
700	1	a Gestel, Holly Van4 aut
700	1	a Vargas, Cristian4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Vreeker, Annabel4 aut
700	1	a Waltemate, Lena4 aut
700	1	a Yatham, Lakshmi N4 aut
700	1	a Ching, Christopher R K4 aut
700	1	a Andreassen, Ole4 aut
700	1	a Thompson, Paul M4 aut
700	1	a Hajek, Tomas4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Molecular psychiatryd : Springer Science and Business Media LLCg 26:11, s. 6806-6819q 26:11<6806-6819x 1476-5578x 1359-4184
856	4	u https://www.nature.com/articles/s41380-021-01098-x.pdf
856	4 8	u https://gup.ub.gu.se/publication/304287
856	4 8	u https://doi.org/10.1038/s41380-021-01098-x
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:146459691

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Av författaren/redakt...: McWhinney, Sean ...; Abé, Christoph; Alda, Martin; Benedetti, Franc ...; Bøen, Erlend; Del Mar Bonnin, ...; visa fler...; Borgers, Tiana; Brosch, Katharin ...; Canales-Rodrígue ...; Cannon, Dara M; Dannlowski, Udo; Díaz-Zuluaga, An ...; Elvsåshagen, Tor ...; Eyler, Lisa T; Fullerton, Janic ...; Goikolea, Jose M; Goltermann, Jani ...; Grotegerd, Domin ...; Haarman, Barthol ...; Hahn, Tim; Howells, Fleur M; Ingvar, Martin; Kircher, Tilo T ...; Krug, Axel; Kuplicki, Rayus ...; Landén, Mikael, ...; Lemke, Hannah; Liberg, Benny; Lopez-Jaramillo, ...; Malt, Ulrik F; Martyn, Fiona M; Mazza, Elena; McDonald, Colm; McPhilemy, Genev ...; Meier, Sandra; Meinert, Susanne; Meller, Tina; Melloni, Elisa M ...; Mitchell, Philip ...; Nabulsi, Leila; Nenadic, Igor; Opel, Nils; Ophoff, Roel A; Overs, Bronwyn J; Pfarr, Julia-Kat ...; Pineda-Zapata, J ...; Pomarol-Clotet, ...; Raduà, Joaquim; Repple, Jonathan; Richter, Maike; Ringwald, Kai G; Roberts, Gloria; Salvador, Raymon ...; Savitz, Jonathan; Schmitt, Simon; Schofield, Peter ...; Sim, Kang; Stein, Dan J; Stein, Frederike; Temmingh, Henk S; Thiel, Katharina; van Haren, Neelt ...; Gestel, Holly Va ...; Vargas, Cristian; Vieta, Eduard; Vreeker, Annabel; Waltemate, Lena; Yatham, Lakshmi ...; Ching, Christoph ...; Andreassen, Ole; Thompson, Paul M; Hajek, Tomas; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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Av lärosätet: Göteborgs universitet; Karolinska Institutet

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