SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Schmid Gerhard)
 

Sökning: WFRF:(Schmid Gerhard) > A Single Nucleotide...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004253naa a2200493 4500
001oai:lup.lub.lu.se:eca7fdfe-ef2e-4d25-99dc-8354527d7280
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/24162652 URI
0247 a https://doi.org/10.2337/dc11-14262 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kacerovsky-Bielesz, Gertrud4 aut
2451 0a A Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans
264 c 2012-01-16
264 1b American Diabetes Association,c 2012
520 a OBJECTIVE-Myocellular ATP synthesis (fATP) associates with insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Short-term endurance training can modify their fATP and insulin sensitivity. This study examines the effects of moderate long-term exercise using endurance or resistance training in this cohort. RESEARCH DESIGN AND METHODS-A randomized, parallel-group trial tested 16 glucose-tolerant nonobese relatives (8 subjects in the endurance training group and 8 subjects in the resistance training group) before and after 26 weeks of endurance or resistance training. Exercise performance was assessed from power output and oxygen uptake (VO2) during incremental tests and from maximal torque of knee flexors (MaxT(flex)) and extensors (MaxT(ext)) using isokinetic dynamometry. fATP and ectopic lipids were measured with H-1/P-31 magnetic resonance spectroscopy. RESULTS Endurance training increased power output and VO2 by 44 and 30%, respectively (both P < 0.001), whereas resistance training increased MaxT(ext) and MaxT(flex) by 23 and 40%, respectively (both P < 0.001). Across all groups, insulin sensitivity (382 +/- 90 vs. 389 +/- 40 mL.min.m(-2)) and ectopic lipid contents were comparable after exercise training. However, 8 of 16 relatives had 26% greater fATP, increasing from 9.5 +/- 2.3 to 11.9 +/- 2.4 mu mol.mL(-1).m(-1) (P < 0.05). Six of eight responders were carriers of the G/G single nucleotide polymorphism rs540467 of the NDUFB6 gene (P = 0.019), which encodes a subunit of mitochondrial complex I. CONCLUSIONS-Moderate exercise training for 6 months does not necessarily improve insulin sensitivity but may increase ATP synthase flux. Genetic predisposition can modify the individual response of the ATP synthase flux independently of insulin sensitivity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Kacerovsky, Michaela4 aut
7001 a Chmelik, Marek4 aut
7001 a Farukuoye, Michaela4 aut
7001 a Ling, Charlotteu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0
7001 a Poican, Rochus4 aut
7001 a Tschan, Harald4 aut
7001 a Szendroedi, Julia4 aut
7001 a Schmid, Albrecht Ingo4 aut
7001 a Gruber, Stephan4 aut
7001 a Herder, Christian4 aut
7001 a Wolzt, Michael4 aut
7001 a Moser, Ewald4 aut
7001 a Pacini, Giovanni4 aut
7001 a Smekal, Gerhard4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Roden, Michael4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t Diabetes Cared : American Diabetes Associationg 35:2, s. 350-357q 35:2<350-357x 1935-5548x 0149-5992
8564 u http://dx.doi.org/10.2337/dc11-1426y FULLTEXT
8564 u https://care.diabetesjournals.org/content/diacare/35/2/350.full.pdf
8564 8u https://lup.lub.lu.se/record/2416265
8564 8u https://doi.org/10.2337/dc11-1426

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy