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  • Juzenas, SimonasInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Institute of Biotechnology, Life Science Centre, Vilnius University, Vilnius, Lithuania,Christian Albrechts Univ Kiel, Germany; Vilnius Univ, Lithuania (author)

Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-11
  • Oxford University Press,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-96450
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96450URI
  • https://doi.org/10.1093/ecco-jcc/jjac003DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183596URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148913901URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:German Research Foundation (DFG) EXC 2167
  • Funding Agencies|European UnionEuropean Commission [733100]; German Research Foundation (DFG) Excellence Cluster Precision Medicine in Chronic Inflammation [PMI]German Research Foundation (DFG) [EXC 2167]; Swedish Foundation for Strategic Research [BIO IBD] [RB13-0160]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2020-02021]
  • BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the gastrointestinal tract, which generally manifests as Crohn's disease (CD) or ulcerative colitis (UC). These subtypes are heterogeneous in terms of disease location and histological features, while sharing common clinical presentation, genetic associations and thus, common immune regulatory pathways.METHODS: Using miRNA and mRNA coupled transcriptome profiling and systems biology approaches, we report a comprehensive analysis of blood transcriptomes from treatment-naïve (n=110) and treatment-exposed (n=177) IBD patients as well as symptomatic- (n=65) and healthy controls (n=95).RESULTS: Broadly, the peripheral blood transcriptomes of CD and UC patients were similar. However, there was an extensive gene deregulation in the blood of IBD patients, while only a slight deregulation in symptomatic controls, when compared with healthy controls. The deregulated mRNAs and miRNAs are mainly involved in the innate immunity and are especially enriched in neutrophil activation-related pathways. Oxidative phosphorylation and neutrophil activation-related modules were found to be differentially co-expressed among treatment-naïve IBD as compared to healthy controls. In the deregulated neutrophil activation-related co-expression module, the IL1B was identified as the central gene. The co-expression levels among IL1B and chemosensing receptor (CXCR1/2 and FPR1/2) genes were reduced in the blood of IBD patients when compared with healthy controls.CONCLUSIONS: Immune dysregulation seen in peripheral blood transcriptomes of treatment-naïve IBD patients is mainly driven by neutrophil activation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hübenthal, MatthiasInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Dermatology, Quincke Research Center, University Hospital Schleswig-Holstein, Kiel, Germany,Christian Albrechts Univ Kiel, Germany; Univ Hosp Schleswig Holstein, Germany (author)
  • Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany; Orebro Univ, Sweden(Swepub:oru)melt (author)
  • Kruse, Robert,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory,iRiSC - Inflammatory Response and Infection Susceptibility Centre,Orebro Univ, Sweden; Orebro Univ, Sweden(Swepub:oru)rke (author)
  • Steiert, Tim AlexanderInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany (author)
  • Degenhardt, FraukeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany (author)
  • Schulte, DominikDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine I, University Hospital of Schleswig-Holstein, Kiel, Germany; Institute of Diabetes and Clinical Metabolic Research, Kiel University, Kiel, Germany,Univ Hosp Schleswig Holstein, Germany; Univ Kiel, Germany (author)
  • Nikolaus, SusannaDepartment of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany,Univ Hosp Schleswig Holstein, Germany (author)
  • Zeissig, SebastianMedical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, Dresden, Germany,Tech Univ Dresden TU Dresden, Germany; Tech Univ TU Dresden, Germany (author)
  • Bergemalm, Daniel,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Orebro Univ, Sweden(Swepub:oru)dbm (author)
  • Almer, SvenDepartment of Medicine, Karolinska Institutet, Solna, and Division of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
  • Hjortswang, HenrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)henhj44 (author)
  • Bresso, FrancescaKarolinska Institutet (author)
  • Strüning, NinaDepartment of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany,SIC IBD working group,Univ Hosp Schleswig Holstein, Germany (author)
  • Kupcinskas, JuozasDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania,Lithuanian Univ Hlth Sci, Lithuania; Lithuanian Univ Hlth Sci, Lithuania (author)
  • Keller, AndreasChair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA,Saarland Univ, Germany; Stanford Univ, CA 94305 USA (author)
  • Lieb, WolfgangInstitute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany (author)
  • Rosenstiel, PhilipInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany (author)
  • Schreiber, StefanInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany,Christian Albrechts Univ Kiel, Germany; Univ Hosp Schleswig Holstein, Germany (author)
  • D'Amato, MauroKarolinska Institutet (author)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden(Swepub:oru)jshn (author)
  • Hemmrich-Stanisak, GeorgInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany,Christian Albrechts Univ Kiel, Germany (author)
  • Franke, AndreInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; University Hospital of Schleswig-Holstein (UKSH), Kiel Campus, Kiel, Germany,Christian Albrechts Univ Kiel, Germany; Univ Hosp Schleswig Holstein UKSH, Germany (author)
  • Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Institute of Biotechnology, Life Science Centre, Vilnius University, Vilnius, LithuaniaChristian Albrechts Univ Kiel, Germany; Vilnius Univ, Lithuania (creator_code:org_t)

Related titles

  • In:Journal of Crohn's & Colitis: Oxford University Press16:7, s. 1097-11091873-99461876-4479

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